Carboxymethylated ɩ-carrageenan conjugated amphotericin B loaded gelatin nanoparticles for treating intracellular Candida glabrata infections

Aparna, V.; Melge, Anu R.; Rajan, Vijisha K.; Biswas, Raja; Jayakumar, R.; Mohan, C. Gopi

doi:10.1016/j.ijbiomac.2017.11.126

Cited by 38 publications

(14 citation statements)

References 29 publications

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“…In this respect, the development of NP-based DDS for AmB to treat IFIs is promising, given the NPs’ ability to target the infected cells and provide a sustained release allowing longer contact between the drug and the fungi/parasite. NPs are being considered extensively to improve AmB delivery ( Table 4 ) 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 . The NP-based DDS employed for AmB delivery for the treatment of IFIs are detailed bellow.…”

Section: Np-based Dds For Ambmentioning

confidence: 99%

Delivery strategies of amphotericin B for invasive fungal infections

Wang

Mohammad

Fan

et al. 2021

Acta Pharmaceutica Sinica B

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Invasive fungal infections (IFIs) represent a growing public concern for clinicians to manage in many medical settings, with substantial associated morbidities and mortalities. Among many current therapeutic options for the treatment of IFIs, amphotericin B (AmB) is the most frequently used drug. AmB is considered as a first-line drug in the clinic that has strong antifungal activity and less resistance. In this review, we summarized the most promising research efforts on nanocarriers for AmB delivery and highlighted their efficacy and safety for treating IFIs. We have also discussed the mechanism of actions of AmB, rationale for treating IFIs, and recent advances in formulating AmB for clinical use. Finally, this review discusses some practical considerations and provides recommendations for future studies in applying AmB for combating IFIs.

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Section: Np-based Dds For Ambmentioning

confidence: 99%

Delivery strategies of amphotericin B for invasive fungal infections

Wang

Mohammad

Fan

et al. 2021

Acta Pharmaceutica Sinica B

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“…Similarly, Aparna et al [ 34 ] have picked gelatin as a polymeric carrier for the delivery of amphotericin B based on an in silico outcome. Among eight different evaluated amino-functionalized polymers, gelatin showed the highest docking score for amphotericin B ( Table 3 ).…”

Section: MD Simulations and Dockingmentioning

confidence: 99%

Evolution of the Computational Pharmaceutics Approaches in the Modeling and Prediction of Drug Payload in Lipid and Polymeric Nanocarriers

et al. 2021

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This review describes different trials to model and predict drug payload in lipid and polymeric nanocarriers. It traces the evolution of the field from the earliest attempts when numerous solubility and Flory-Huggins models were applied, to the emergence of molecular dynamic simulations and docking studies, until the exciting practically successful era of artificial intelligence and machine learning. Going through matching and poorly matching studies with the wet lab-dry lab results, many key aspects were reviewed and addressed in the form of sequential examples that highlighted both cases.

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“…Hydrogels fabricated with this approach showed super strong interface bonding [84,85]. In addition, various chemical modifications of the carrageenan backbone with hydroxyl/sulphate groups, such as oversulphated, acetylated, phosphorylated [86], oxidized [87], carboxmethylated [88], and methacrylated [81] modifications, also have been used to overcome this weakness [89].…”

Section: Characteristics and Potentials Of Main Marine-derived Biomentioning

confidence: 99%

Biomaterials Based on Marine Resources for 3D Bioprinting Applications

et al. 2019

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Three-dimensional (3D) bioprinting has become a flexible tool in regenerative medicine with potential for various applications. Further development of the new 3D bioprinting field lies in suitable bioink materials with satisfied printability, mechanical integrity, and biocompatibility. Natural polymers from marine resources have been attracting increasing attention in recent years, as they are biologically active and abundant when comparing to polymers from other resources. This review focuses on research and applications of marine biomaterials for 3D bioprinting. Special attention is paid to the mechanisms, material requirements, and applications of commonly used 3D bioprinting technologies based on marine-derived resources. Commonly used marine materials for 3D bioprinting including alginate, carrageenan, chitosan, hyaluronic acid, collagen, and gelatin are also discussed, especially in regards to their advantages and applications.

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Carboxymethylated ɩ-carrageenan conjugated amphotericin B loaded gelatin nanoparticles for treating intracellular Candida glabrata infections

Cited by 38 publications

References 29 publications

Delivery strategies of amphotericin B for invasive fungal infections

Delivery strategies of amphotericin B for invasive fungal infections

Evolution of the Computational Pharmaceutics Approaches in the Modeling and Prediction of Drug Payload in Lipid and Polymeric Nanocarriers

Biomaterials Based on Marine Resources for 3D Bioprinting Applications

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