Carboxymethyl tara gum-lactoferrin complex coacervates as carriers for vitamin D3: Encapsulation and controlled release

Santos, Monique Barreto; Carvalho, Mário Geraldo de; Garcia‐Rojas, Edwin Elard

doi:10.1016/j.foodhyd.2020.106347

Cited by 54 publications

(15 citation statements)

References 48 publications

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“…Some groups of formulations were able to release vitamin d3 in a controlled manner, such as microspheres and nanoparticles of hydrophobic alginate derivatives as oral carriers for the sustained release of vitamin D 3 84 , 85 . Thus, the development of a crosslinking process, stability tests and in vivo release for this system will be necessary.…”

Section: Resultsmentioning

confidence: 99%

Controlled release of vitamin D3 using a nanocellulose-based membrane

Colturato

Goveia

2022

Sci Rep

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Epidemiological studies show that a significant fraction of the global population presents low levels of vitamin D3. In order to address this problem, one way to administer the vitamin is to incorporate it in novel drug delivery systems, such as transdermal devices. A possible substance for this purpose is cellulose, which has a long history of use in the health area. However, the application of nanostructured cellulose membranes, as local drug delivery systems, remains a challenge. To develop a crystalline nanocellulose membrane as a new tool for the release of vitamin D3. A new nanostructured membrane containing nanocellulose extracted from cotton linter and vitamin D3 was produced using the “casting” technique. The membrane was characterized using high-resolution scanning electron microscopy (FEG-SEM) and Fourier transform infrared spectroscopy (FT-IR). The kinetics of vitamin release was quantified using molecular spectroscopy (UV–Vis). The FT-IR spectra showed the presence of all the active components in the membrane sample, without structural alterations or the formation of new bonds. The FEG-SEM images showed the presence of vitamin crystals on the surface and in the interior of the membrane. The release of vitamin D3 occurred in a sustained manner, obtaining 3029 IU mL−1 of vitamin D3 in 60 min. The findings demonstrated that the membrane could be used for the sustained release of vitamin D3. This new biomaterial has potential as a new model for vitamin supplementation in individuals with vitamin D3 deficiency.

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Section: Resultsmentioning

confidence: 99%

Controlled release of vitamin D3 using a nanocellulose-based membrane

Colturato

Goveia

2022

Sci Rep

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“…The process of carboxymethylation consists of the insertion of negatively charged carboxymethyl groups in the main polysaccharide, thus favouring the formation of complex coacervates [ 62 ]. Taking the advantage of this property, Santos et al [ 63 ] performed the microencapsulation of vitamin D3 through complex coacervation in matrices formed by carboxymethyl tara gum and LF. To promote the electrostatic interaction between tara gum and LF, the system was shaken for 10 min at 300 rpm and then quickly placed in an ice bath to reduce the temperature.…”

Section: Resultsmentioning

confidence: 99%

“…The complex coacervation of LF with biopolymers increases its stability during gastric digestion since the acidic pH of the stomach maintains both polymers with opposite charges supporting their interaction. However, intestinal pH (7) has a negative effect on coacervation since this pH modifies the positive charge of LF necessary for the interaction with tara gum [ 63 ]. Therefore, these complexes improved the stability and facilitated the controlled release of the vitamin during GIT digestion.…”

Section: Resultsmentioning

confidence: 99%

Development of Encapsulation Strategies and Composite Edible Films to Maintain Lactoferrin Bioactivity: A Review

2021

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Lactoferrin (LF) is a whey protein with various and valuable biological activities. For this reason, LF has been used as a supplement in formula milk and functional products. However, it must be considered that the properties of LF can be affected by technological treatments and gastrointestinal conditions. In this article, we have revised the literature published on the research done during the last decades on the development of various technologies, such as encapsulation or composite materials, to protect LF and avoid its degradation. Multiple compounds can be used to conduct this protective function, such as proteins, including those from milk, or polysaccharides, like alginate or chitosan. Furthermore, LF can be used as a component in complexes, nanoparticles, hydrogels and emulsions, to encapsulate, protect and deliver other bioactive compounds, such as essential oils or probiotics. Additionally, LF can be part of systems to deliver drugs or to apply certain therapies to target cells expressing LF receptors. These systems also allow improving the detection of gliomas and have also been used for treating some pathologies, such as different types of tumours. Finally, the application of LF in edible and active films can be effective against some contaminants and limit the increase of the natural microbiota present in meat, for example, becoming one of the most interesting research topics in food technology.

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“…The complex coacervates obtained using CMTG along with gelatin-A were utilized to encapsulate vitamin D 3 to improve thermal stability and to get the prolonged release of vitamin D 3 [65]. TG together with lactoferrin [66] and gelatin-A [65] was used during the encapsulation process of vitamin D 3 using complex coacervation. TG with the introduction of a negative charge exhibited complexation with proteins (positive charge) via electrostatic interactions.…”

Section: Carboxymethylationmentioning

confidence: 99%

Chemistry, Biological Activities, and Uses of Tara Gum

Desai¹,

Prajapati²,

Chandarana³

2022

Reference Series in Phytochemistry

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Galactomannans are high molecular weight plant polysaccharides obtained from legume seeds of annual crops or perennial trees and shrubs. These heteropolysaccharides are mainly made up of a D-mannose backbone and a D-galactose side chain. Tara gum (TG), a galactomannan with a mannose to galactose ratio of 3:1, is obtained from the seed endosperm of Caesalpinia spinosa. The gum has gained popularity due to its properties and functionality comparable to that of

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Carboxymethyl tara gum-lactoferrin complex coacervates as carriers for vitamin D3: Encapsulation and controlled release

Cited by 54 publications

References 48 publications

Controlled release of vitamin D3 using a nanocellulose-based membrane

Controlled release of vitamin D3 using a nanocellulose-based membrane

Development of Encapsulation Strategies and Composite Edible Films to Maintain Lactoferrin Bioactivity: A Review

Chemistry, Biological Activities, and Uses of Tara Gum

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