Carboxymethyl Mungbean Starch as a New Pharmaceutical Gelling Agent for Topical Preparation

Kittipongpatana, Ornanong S.; Burapadaja, Siriporn; Kittipongpatana, Nisit

doi:10.1080/03639040802144229

Cited by 19 publications

(12 citation statements)

References 30 publications

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“…The higher absorption observed in all chemically modified starches could partially be attributed to the interaction between the substituted groups and the oil. The increases in OAC were also reported from carboxymethyl starch of papaya [ 38 ], hydroxypropyl starch of water yam [ 39 ], and crosslinked carboxymethyl mungbean starch [ 40 ].…”

Section: Resultssupporting

confidence: 56%

Physicochemical and Functional Properties of Modified KJ CMU-107 Rice Starches as Pharmaceutical Excipients

Kittipongpatana

2022

Polymers

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Starch extracted from KJ CMU-107 rice, with amylose content of 13.4%, was modified to yield pre-gelatinized starch (PGS), carboxymethyl starch (CMS), crosslinked carboxymethyl starch (CLCMS), crosslinked starch (CLS), and hydroxypropyl starch (HPS). Their physicochemical properties were assessed in comparison with the native starch (NS), and their functional properties were then evaluated for potential use as pharmaceutical excipients. Scanning electron microscopic (SEM) images and X-ray diffraction (XRD) patterns showed that granules of all but one of the modified starches retained the native character and crystalline arrangement. The exception, PGS, exhibited extensive granular rupture, which correlated with the loss of crystallinity suggested by the amorphous halo in XRD. Energy-dispersive X-ray (EDX) data confirmed the modification by the presence of related elements. Carboxymethylation increased solubility in unheated water, while crosslinking improved swelling. All modified starches displayed improved oil absorption capacity by 17–64%, while CMS and CLCMS also exhibited significant moisture sorption at above 75% RH PGS and HPS exhibited lower gelatinization temperature (Tg) and enthalpic change (ΔH), while CLS showed higher Tg and ΔH. CMS, CLCMS, and CLS showed adequate powder flow and compactibility, qualifying as potential tablet excipients. The 5% w/v solutions of CMS, CLMS, and HPS also formed intact films with suitable tensile strength. Overall, modified starches derived from KJ CMU-107 could potentially be developed into new pharmaceutical excipients.

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Section: Resultssupporting

confidence: 56%

Physicochemical and Functional Properties of Modified KJ CMU-107 Rice Starches as Pharmaceutical Excipients

Kittipongpatana

2022

Polymers

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“…Non-crosslinked CMS-based films are soluble in cold water [ 4 , 5 ]. Applying crosslinking agent, such as: sodium trimetaphosphate [ 6 ], sodium hexametaphosphate [ 7 ], dichloroacetic acid [ 8 ], or multifunctional carboxylic acids [ 9 , 10 ] allowed to obtained hydrogel material with various swelling capacity. The mechanical strength of CMS-based films could be improved by introducing clay nanoparticles [ 7 , 10 ] or by blending CMS with other polymer, e.g., starch [ 11 ] or zein [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic Films Based on Carboxymethylated Derivatives of Starch and Cellulose

et al. 2020

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The carboxymethylated derivatives of starch (CMS) and cellulose (CMC) were used for film preparation. The infrared spectroscopy revealed that crosslinking via ester bridges with citric acid occurred between the two polysaccharide derivatives. The effect of polysaccharide derivatives ratio on physicochemical properties of prepared films was evaluated. Generally, the values of tested parameters (moisture absorption, surface roughness, and mechanical and thermal properties) were between the values noted for neat CMS or CMC-based films. However, the physicochemical properties of the system with equal CMS/CMC weight ratio diverged from this trend, i.e., the highest tensile strength, the highest Young’s modulus (ca. 3.4 MPa and ca. 4.9 MPa, respectively), with simultaneously the lowest moisture absorption (18.5% after 72 h) have been noted. Such systems could potentially find application in agriculture or pharmacy.

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“…For example, starches substituted with groups like carboxymethyl [13][14] or hydroxypropyl [15] or acetate [16], and starches cross-linked by various agents such as epichlorohydrin and sodium trimetaphosphate have all retarded drug release from solid dosage forms at various levels [17]. Also, carboxymethyl starch showed the ideal properties of a gelling agent [18] and tablet disintegrants [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations

Brhane

2020

PLoS ONE

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Some excipients are currently available for the formulation of pharmaceutical suspensions. The objective of this study is to develop cheap and effective starch-based excipient that can be used as an effective alternative for the formulation of pharmaceutical suspensions. Carboxymethylated Plectranthus edulis, Vatke (P. edulis) [fam., Lamiaceae], starch was evaluated as a suspending agent in metronidazole benzoate suspensions in comparison with sodium carboxymethyl cellulose (NaCMC) at a concentration range of 1-4% (w/v). The resulting suspensions were evaluated for their sedimentation volume (%), degree of flocculation, rheology, redispersibility, and dissolution rate. Stability studies were performed for 3 months. The apparent viscosities of the formulations prepared with carboxymethylated P. edulis starch at reaction condition E (CMPS-E) was significantly lower than that of NaCMC (p < 0.05). The flowability of the suspensions, at all concentration levels of the suspending agents, were in the order of CMPS-E > NaCMC. AT 1% concentrations, carboxymethylated P. edulis starch (76 ± 1.5%) provided significantly higher (p < 0.05) sedimentation volume than NaCMC (40 ± 1.5%). At 3% and 4%, both gave comparable sedimentation volume (100%). Potassium dihydrogen phosphate (KH 2 PO 4) employed as a flocculating agent significantly increased (p < 0.05) the sedimentation volume of the suspensions prepared with carboxymethylated P.edulis starch and NaCMC. The redispersibilities of CMPS-E were better than those of NaCMC. All suspensions showed a release of greater than 85% of drug within 1 h. The results of stability studies showed that all suspension formulations were stable. From the foregoing, it can be concluded that carboxymethylated P. edulis starch could be used as an alternative suspending agent.

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Carboxymethyl Mungbean Starch as a New Pharmaceutical Gelling Agent for Topical Preparation

Cited by 19 publications

References 30 publications

Physicochemical and Functional Properties of Modified KJ CMU-107 Rice Starches as Pharmaceutical Excipients

Physicochemical and Functional Properties of Modified KJ CMU-107 Rice Starches as Pharmaceutical Excipients

Hydrophilic Films Based on Carboxymethylated Derivatives of Starch and Cellulose

Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations

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