Carboxymethyl-kappa-carrageenan: A study of biocompatibility, antioxidant and antibacterial activities

Madruga, Liszt Y. C.; Sabino, Roberta M.; Santos, Elizabeth Cristina Gomes dos; Popat, Ketul C.; Balaban, Rosângela de Carvalho; Kipper, Matt J.

doi:10.1016/j.ijbiomac.2020.02.274

Cited by 88 publications

(49 citation statements)

References 55 publications

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“…The antibacterial activity could be due to the presence of sulphate, and carboxylate groups may create an acidic pH environment; it is also possible that the carboxylate groups could increase the nucleophilicity of the polymer. Although the authors recommended further studies on this subject, they noted that antioxidant, antibacterial, and biocompatibility tests could confirm potential applications of this polymer, such as for wound dressings and scaffolds [ 82 ].…”

Section: Bioactive Properties Of Carrageenanmentioning

confidence: 99%

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Carrageenan: Drug Delivery Systems and Other Biomedical Applications

2020

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Marine resources are today a renewable source of various compounds, such as polysaccharides, that are used in the pharmaceutical, medical, cosmetic, and food fields. In recent years, considerable attention has been focused on carrageenan-based biomaterials due to their multifunctional qualities, including biodegradability, biocompatibility, and non-toxicity, in addition to bioactive attributes, such as their antiviral, antibacterial, antihyperlipidemic, anticoagulant, antioxidant, antitumor, and immunomodulating properties. They have been applied in pharmaceutical formulations as both their bioactive and physicochemical properties make them suitable biomaterials for drug delivery, and recently for the development of tissue engineering. This article provides a review of recent research on the various types of carrageenan-based biomedical and pharmaceutical applications.

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Section: Bioactive Properties Of Carrageenanmentioning

confidence: 99%

“…Studies carried out in recent years have shown that CG also has significant antioxidant activity, a property associated with sulphate group content [ 82 , 104 ]. Gomez-Ordoñez et al tested CG sequentially extracted from Mastocarpus stellatus with water, acid, and alkali.…”

Section: Bioactive Properties Of Carrageenanmentioning

confidence: 99%

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

2020

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“…Carboxymethylation is another modification of polysaccharides that can increase their properties. The existence of sulfate and carboxylate groups in carboxymethyl-kappa- carrageenan caused antibacterial activity due to an acidic pH ambience [ 63 ]. In a study, researchers used hydrogen peroxide (H 2 O 2 ) and a copper sulfate (CuSO 4 ) redox system for the modification of κ-carrageenan (oxidized κ-carrageenan(κ-Ox-3)), and they investigated its effect on the antibacterial ability ( Figure 3 B).…”

Section: Chemical Modification Of Carrageenanmentioning

confidence: 99%

Recent Advances in Chemically-Modified and Hybrid Carrageenan-Based Platforms for Drug Delivery, Wound Healing, and Tissue Engineering

et al. 2021

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Recently, many studies have focused on carrageenan-based hydrogels for biomedical applications thanks to their intrinsic properties, including biodegradability, biocompatibility, resembling native glycosaminoglycans, antioxidants, antitumor, immunomodulatory, and anticoagulant properties. They can easily change to three-dimensional hydrogels using a simple ionic crosslinking process. However, there are some limitations, including the uncontrollable exchange of ions and the formation of a brittle hydrogel, which can be overcome via simple chemical modifications of polymer networks to form chemically crosslinked hydrogels with significant mechanical properties and a controlled degradation rate. Additionally, the incorporation of various types of nanoparticles and polymer networks into carrageenan hydrogels has resulted in the formation of hybrid platforms with significant mechanical, chemical and biological properties, making them suitable biomaterials for drug delivery (DD), tissue engineering (TE), and wound healing applications. Herein, we aim to overview the recent advances in various chemical modification approaches and hybrid carrageenan-based platforms for tissue engineering and drug delivery applications.

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“…Some polysaccharides also have known antioxidant activity, including chitosans, carrageenans, fucoidan, alginates, and many others [ 320 , 321 ]. Scavenging reactive oxygen species and reactive nitrogen species can promote wound healing and protect GFs from degradation.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.

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Carboxymethyl-kappa-carrageenan: A study of biocompatibility, antioxidant and antibacterial activities

Cited by 88 publications

References 55 publications

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

Recent Advances in Chemically-Modified and Hybrid Carrageenan-Based Platforms for Drug Delivery, Wound Healing, and Tissue Engineering

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

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