Carboxymethyl-glucan from Saccharomyces cerevisiae reduces blood pressure and improves baroreflex sensitivity in spontaneously hypertensive rats

Abstract

Carboxymethyl-glucan (CMG) is a derivative of β-D-glucan extracted from Sacharomyces cerevisae. This polymer presents improved physicochemical properties and shows health benefits, such as immunomodulation, antioxidant, anti-inflammatory, anti-tumor, and antiplatelet activities,...

Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats

“…Moreover, a reduction in the heart, a target organ, was observed by decreasing cardiac hypertrophy. 21 This finding is consistent with a previous study conducted by Carvalho-Galvão et al , 20 who verified a reduction in blood pressure in renovascular hypertensive animals treated with CMG (40 mg kg −1 ) for two weeks through improvement in baroreflex responses. This evidence indicates that this derivative can act as a cardioprotective agent.…”

“…In addition, this derivative interfered with weight gain, lipid profile, and renal function and promoted reduction in cardiac hypertrophy. 21 We also observed that CMG shows interesting biological effects on the cardiovascular system, such as anti-inflammatory effects, platelet antiaggregant properties, positive modulatory action on vascular function, and action on cardiac function, exhibiting a negative inotropic effect. The antiaggregant activity of CMG was found in vitro at different concentrations (100 and 300 µg mL −1 ) and in healthy animals treated with 20 mg kg −1 for 8 days.…”

“…In addition, this derivative interfered with weight gain, lipid profile, and renal function and promoted reduction in cardiac hypertrophy. 21…”

An important polysaccharide from fermentum

“…Therefore, some scholars applied it to the treatment of hypertension in mice, and they found that Fermentum β-polysaccharide modified by carboxymethylation could promote lower blood pressure and thus reduce myocardial hypertrophy. The mechanism of blood pressure-lowering lies in improving pressure reflex sensitivity by modulating sympathetic tone and possibly regulating renal function in mice to achieve a blood pressure-lowering effect ( Bezerra et al, 2017 , Bezerra et al, 2021 ). In addition, carboxymethylated Fermentum beta-polysaccharide was able to reduce the degree of oxidative damage in the body by significantly reducing malondialdehyde in men ( Araújo et al, 2015 ).…”

Yeast Hydrolysate Inhibits Lipid Accumulation via Regulation of Lipid Accumulation-Related Genes in a Drosophila Model of High-Sugar Diet-Induced Obesity

“…Saccharomyces cerevisiae, baker's and brewer's yeasts, are known to have free radical scavenging, stress-resistant, and immune activation capacities and are essential microorganisms in food biotechnology. Further, the beneficial effects of selenium and carboxymethylglucan-rich hydrolysates from yeast on psoriasis-like dermatitis and baroreflex sensitivity have been reported in in vitro and in vivo experiments [7,8]. In clinical trials using chemical hydrolysates of yeast, β-glucan-chitin-chitosan showed significant changes in body weight, waist circumference, and abdominal fat accumulation without adverse effects [9].…”