Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats

Abstract

Carboxymethyl-glucan is a semi-synthetic derivative of β-D-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is...

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“…The release of vasoconstrictor agents exceeds the release of vasodilator agents leading to vascular instability. The affected endothelium is a focus of platelet activation, which leads to the formation of blood clots and reactive oxygen species [4][5][6]. Adhesion molecules, together with chemokines, are activated by the damaged endothelium to attract leukocytes, which ensures the development of both innate and adaptive immune responses, including loss of tolerance to autoantigens, for instance, topoisomerase I [7,8].…”