Carboxymethyl chitosan prevents formation of broad-spectrum biofilm

Tan, Yulong; Han, Feng; Ma, Su; Yu, Wengong

doi:10.1016/j.carbpol.2011.01.036

Cited by 56 publications

(42 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, chitosan amino and hydroxyl groups can be easily reacted and chemically modified, thus allowing a high chemical versatility. For example, chitosan may be modified into N-carboxymethyl chitosan [115], N-carboxybutyl chitosan [116,117], N-succinyl chitosan [118], N-acyl chitosan [119], N,O-(carboxymethyl) chitosan [120], N-N-dicarboxymethyl chitosan [121], N-carboxyethyl chitosan [122], O-succinyl chitosan [123], Ocarboxymethyl chitosan [124], 5-methylpyrrolidinone [125] and more. The conditions employed for amino group chemical modification may interfere with the final degree of deacetylation and therefore with the cationic nature of the obtained materials.…”

Section: Dfu Dressings Based On Natural Polymersmentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

View full text Add to dashboard Cite

a b s t r a c tDiabetic foot ulcers (DFUs) are a chronic, non-healing complication of diabetes that lead to high hospital costs and, in extreme cases, to amputation. Diabetic neuropathy, peripheral vascular disease, abnormal cellular and cytokine/chemokine activity are among the main factors that hinder diabetic wound repair. DFUs represent a current and important challenge in the development of novel and efficient wound dressings. In general, an ideal wound dressing should provide a moist wound environment, offer protection from secondary infections, remove wound exudate and promote tissue regeneration. However, no existing dressing fulfills all the requirements associated with DFU treatment and the choice of the correct dressing depends on the wound type and stage, injury extension, patient condition and the tissues involved. Currently, there are different types of commercially available wound dressings that can be used for DFU treatment which differ on their application modes, materials, shape and on the methods employed for production. Dressing materials can include natural, modified and synthetic polymers, as well as their mixtures or combinations, processed in the form of films, foams, hydrocolloids and hydrogels. Moreover, wound dressings may be employed as medicated systems, through the delivery of healing enhancers and therapeutic substances (drugs, growth factors, peptides, stem cells and/or other bioactive substances). This work reviews the state of the art and the most recent advances in the development of wound dressings for DFU treatment. Special emphasis is given to systems employing new polymeric biomaterials, and to the latest and innovative therapeutic strategies and delivery approaches.

show abstract

Section: Dfu Dressings Based On Natural Polymersmentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Chitosan and carboxymethyl chitosan with a smaller molecular weight tend to have smaller polymer size 23 . If the size of the polymer decreases the rigidity and steric hindrance also declined.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Biodegradable Film Chitosan and Carboxymethyl Chitosan to Substitute Silver Wound Healer Plaster

Setyawati¹,

Kartini²,

Pranowo³

et al. 2017

Orient. J. Chem

View full text Add to dashboard Cite

Currently, wound dressing is made of fabric or polyvinyl chloride (PVC) plastics with silver as active ingredients. Residues of silver can be toxic in the environment and PVC waste is a very long decomposed by soil. Chitosan and carboxymethyl chitosan (CMC) film have been synthesized as a biodegradable material that potential to replace silver wound plasters. CMC film has been synthesized from chitosan with a wide range of molecular weight. Chitosan with high molecular weight resulting from the reflux (1a) while the low molecular weight chitosan produced from microwaves assisted organic synthesis-MAOS (1b). All chitosan and CMC are then molded into a film chitosan and CMC and their properties were analyzed by solubility test. The COOH number of the CMC is also measured by titration. The results show that the CMC were synthesized from chitosan MAOS (2b) has higher COOH group than CMC from chitosan reflux (2a). Chitosan with MAOS process is able to produce a more homogeneous and has a lower molecular weight in a short time. Chitosan 1a films are strong and rigid while chitosan films 1b and CMC films have fragile nature. Test of solubility in physiological solution showed that the CMC films lost 78.56% Massa while chitosan films 1a only 44.59%. This show that a combination of chitosan films for wound plaster with CMC films as a wound healer active ingredient is suitable for replacing the fabric wound plasters contains silver as an active ingredient.

show abstract

“…Chitosan is a cationic polymer whose positive charge interacts with a negative charge of the microbial cell membrane, resulting in disruption and agglutination [153]. Carboxymethyl chitosan has been reported as a broad spectrum antibioilm agent which can prevent bioilm formation for E. coli and S. aureus by 81.6 and 4.6%, respectively [154].…”

Section: Polymer-based Antimicrobial Dressingsmentioning

confidence: 99%

Antimicrobial Dressings for Improving Wound Healing

Sarheed¹,

Ahmed²,

Shouqair³

et al. 2016

Wound Healing - New Insights Into Ancient Challenges

View full text Add to dashboard Cite

Wound healing occurs by a series of interrelated molecular events which work together to restore tissue integrity and cellular function. These physiological events occur smoothly in normal healthy individual and/or under normal conditions. However, in certain cases, these molecular events are retarded resulting in hard-to-heal or chronic wounds arising from several factors such as poor venous return, underlying physiological or metabolic conditions such as diabetes as well as external factors such as poor nutrition. In most cases, such wounds are infected and infection also presents as another complicating phenomenon which triggers inlammatory reactions, therefore delaying wound healing. There has therefore been recent interests and signiicant eforts in preventing and actively treating wound infections by directly targeting infection causative agents through direct application of antimicrobial agents either alone or loaded into dressings (medicated). These have the advantage of overcoming challenges such as poor circulation in diabetic and leg ulcers when administered systemically and also require lower amounts to be applied compared to that required via oral or iv administration. This chapter will review and evaluate various antimicrobial agents used to target infected wounds, the means of delivery, and current state of the art, including commercially available dressings. Data sources will include mainly peer-reviewed literature, clinical trials and reports, patents as well as government reports where available.

show abstract

Carboxymethyl chitosan prevents formation of broad-spectrum biofilm

Cited by 56 publications

References 39 publications

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Synthesis and Characterization of Biodegradable Film Chitosan and Carboxymethyl Chitosan to Substitute Silver Wound Healer Plaster

Antimicrobial Dressings for Improving Wound Healing

Contact Info

Product

Resources

About