Carboxymethyl chitosan/phospholipid bilayer-capped mesoporous carbon nanoparticles with pH-responsive and prolonged release properties for oral delivery of the antitumor drug, Docetaxel

Zhang, Yanzhuo; Zhu, Wufu; Zhang, Heran; Han, Jihong; Zhang, Lihua; Lin, Qisi; Ai, Fengwei

doi:10.1016/j.ijpharm.2017.09.023

Cited by 34 publications

(8 citation statements)

References 43 publications

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“…100 Another interesting carrier based on a carboxymethyl chitosan phospholipid bilayer capped mesoporous carbon NP was reported for the oral delivery of DTX with sustained release. 101 This hybrid nanocarrier was successful in maintaining a high pay load due to an anionic lipid layer and later showed pH-responsive sustained release in gastric media owing to a cationic polymer envelopment. Moreover, the nanocarriers showed improved mucoadhesion.…”

Section: Hybrid Npsmentioning

confidence: 99%

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

Sohail

Rehman

Sarwar

et al. 2018

IJN

104

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The oral delivery of cancer chemotherapeutic drugs is challenging due to low bioavailability, gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux pumps. Thus, chemotherapeutic drugs, including Docetaxel, are administered via an intravenous route, which poses many disadvantages of its own. Recent advances in pharmaceutical research have focused on designing new and efficient drug delivery systems for site-specific targeting, thus leading to improved bioavailability and pharmacokinetics. A decent number of studies have been reported for the safe and effective oral delivery of Docetaxel. These nanocarriers, including liposomes, polymeric nanoparticles, metallic nanoparticles, hybrid nanoparticles, dendrimers and so on, have shown promising results in research papers and clinical trials. The present article comprehensively reviews the research efforts made so far in designing various advancements in the oral delivery of Docetaxel. Different strategies to improve oral bioavailability, prevent first-pass metabolism and inhibition of efflux pumping leading to improved pharmacokinetics and anticancer activity are discussed. The final portion of this review article presents key issues such as safety of nanomaterials, regulatory approval and future trends in nanomedicine research.

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Section: Hybrid Npsmentioning

confidence: 99%

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

Sohail

Rehman

Sarwar

et al. 2018

IJN

104

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“…The incorporation of phospholipids and was found to increase the sustained release effects of the liposomes. Additionally, the carboxymethyl chitosan and phospholipids layers were shown to reduce the toxicity of mesoporous carbon matrix, which can lead to increased biocompatibility [83].…”

Section: Plant Polyphenols and Pospholipids-based Nanocarriersmentioning

confidence: 99%

Role and Merits of Green Based Nanocarriers in Cancer Treatment

Elbagory

Marima

Dlamini

2021

Cancers

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The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These “smart” vehicles enhance the dissolution and the bioavailability of drugs and enable their delivery to the target site. Taking the potential toxicity into consideration, the incorporation of natural “green” materials, derived from plants or microbial sources, in the nanocarriers fabrication, improve their safety and biocompatibility. These green components can be used as a mechanical platform or as targeting ligand for the payload or can play a role in the synthesis of nanoparticles. Several studies reported the use of green based nanocarriers for the treatment of diseases such as cancer. This review article provides a critical analysis of the different types of green nanocarriers and their synthesis mechanisms, characterization, and their role in improving drug delivery of anticancer drugs to achieve precision cancer treatment. Current evidence suggests that green-based nanocarriers can constitute an effective treatment against cancer.

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“…These NPs should be able to effectively release a drug in the intestine while protecting the drug from degradation in the stomach. Carboxymethyl CS/phospholipid bilayer-capped mesoporous carbon NPs are useful nanocarriers in the delivery of anti-tumor drugs such as DTX [133]. These nanocarriers are composed of three individual parts: A) a mesoporous carbon nano matrix [131] for drug loading; B) a positively charged phospholipid (PL) layer providing the sustained release of a drug and C) a negatively charged carboxymethyl CS (CCS) provides pH-responsive drug release.…”

Section: Ph-responsive Chitosan Nanoparticlesmentioning

confidence: 99%

Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

Ashrafizadeh

Ahmadi

Mohamadi

et al. 2020

International Journal of Biological Macromolecules

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Paclitaxel (PTX) and docetaxel (DTX) are key members of taxenes with high anti-tumor activity against various cancer cells. These chemotherapeutic agents suffer from a number of drawbacks and it seems that low solubility in water is the most important one. Although much effort has been made in improving the bioavailability of PTX and DTX, the low bioavailability and minimal accumulation at tumor sites are still the challenges faced in PTX and DTX therapy.As a consequence, biomaterial-synthesized NPs have attracted much attention due to unique properties. Among them, chitosan (CS) is of interest due to its great biocompatibility. CS is a positively charged polysaccharide with the capability of interaction with negatively charged biomolecules. Besides, it can be processed into the sheet, micro/nano-particles, scaffold, and is dissolvable in mildly acidic pH similar to the pH of the tumor microenvironment. Keeping in mind the different applications of CS in the preparation of nanocarriers for delivery of PTX and DTX, in the present review, we demonstrate that how CS functionalized-nanocarriers and CS modification can be beneficial in enhancing the bioavailability of PTX and DTX, targeted delivery at tumor site, image-guided delivery and co-delivery with other anti-tumor drugs or genes.

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Carboxymethyl chitosan/phospholipid bilayer-capped mesoporous carbon nanoparticles with pH-responsive and prolonged release properties for oral delivery of the antitumor drug, Docetaxel

Cited by 34 publications

References 43 publications

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

Role and Merits of Green Based Nanocarriers in Cancer Treatment

Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

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