Carboxymethyl chitosan grafted trisiloxane surfactant nanoparticles with pH sensitivity for sustained release of pesticide

Zhao, Ming; Zhou, Hongjun; Chen, Long; Li, Hao; Chen, Huayao; Zhou, Xinhua

doi:10.1016/j.carbpol.2020.116433

Cited by 77 publications

(33 citation statements)

References 54 publications

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“…The release kinetics of RAG1‐IDE, RA‐IDE and IDE alone in SIF and SGF were evaluated by plotting the cumulative release data versus time and fitting to the zero‐order, first‐order, Higuchi plane diffuse and Ritger–Peppas equations 8,29 . Supporting Information Table S1 shows the linear fitting correlation coefficients ( R 2 ) derived from the empirical equations.…”

Section: Resultsmentioning

confidence: 99%

A comparative study on physicochemical and micellar solubilization performance between monoglucosyl rebaudioside A and rebaudioside A

et al. 2021

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BACKGROUND Rebaudioside A (RA) and its monoglucosyl derivative, as like rebaudioside D (RD) are the most popular stevia glycosides but possess poor solubility in water, which limited their application as edible surfactants, the applications as in micellar solubilization and drug delivery. Meanwhile, effect of the monoglucosyl attached to RA moiety remains unclear. RESULTS Monoglucosyl rebaudioside A (RAG1) was synthesized via hydrolyzing the transglycosylation product of RA with 95% of RA converted. RAG1 content in raw reaction mixture was as high as 69.5% of total glycosides, and harvested with a content of 88.2% by simple filtration. The RAG1 exhibited an aqueous solubility of 87 folds of RA or 391 folds of RD at 25 °C. The surface activity of RAG1 solution was higher than RA and invincible to RD. The RAG1 micelles promoted aqueous solubility of idebenone (IDE) up to 500 folds higher at 25 °C. The cumulative release rate of IDE encapsulated in RAG1 micelles was 777.5% or 456.7% higher of that of free IDE in simulated gastric/intestinal fluids in 14 h, respectively. The RAG1‐IDE remained the same in 98 days at 25 °C. CONCLUSION The α‐linked glucosyl to RA induced higher hydrophilicity and surface activity than that resulted by β‐linked glucosyl, making RAG1 not only dramatically raise the aqueous solubility of RA, but also endow IDE folds higher in bioaccessibility, yet making the capsule stable at storage. The results would provide a new edible delivery nanocarrier for encapsulation of hydrophobic bioactive components. © 2021 Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 99%

A comparative study on physicochemical and micellar solubilization performance between monoglucosyl rebaudioside A and rebaudioside A

et al. 2021

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“…The main loss in the first stage up to 150 °C was due to the loss of adsorbed water. The second decomposition of CMCS, starting from 200 to 800 °C, was due to the decomposition of the polysaccharide [ 39 ]. The DTG curves show that the maximum decomposition rate of CMCS occurred at the peak of 267 °C, whereas the CMCS-DEACMS displayed a maximum weight loss rate at 296 °C, which indicates that the thermal stability was enhanced after introduction of the pendant DEACMS groups.…”

Section: Resultsmentioning

confidence: 99%

“…It can even stimulate the innate immune systems of plants and improve resistance against disease and insects [ 37 ]. Chitosan molecules with enormous hydroxyls and amino groups can be readily modified for encapsulation and controlled release of agrochemicals, including herbicides, insecticides, plant growth regulators and fertilizers [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Coumarin-Containing Light-Responsive Carboxymethyl Chitosan Micelles as Nanocarriers for Controlled Release of Pesticide

et al. 2020

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Currently, controlled release formulations (CRFs) of pesticides in response to biotic and/or abiotic stimuli have shown great potential for providing “on-demand” smart release of loaded active ingredients. In this study, amphiphilic biopolymers were prepared by introducing hydrophobic (7-diethylaminocoumarin-4-yl)methyl succinate (DEACMS) onto the main chain of hydrophilic carboxymethylchitosan (CMCS) via the formation of amide bonds which were able to self-assemble into spherical micelles in aqueous media and were utilized as light-responsive nanocarriers for the controlled release of pesticides. FTIR and NMR characterizations confirmed the successful synthesis of the CMCS-DEACMS conjugate. The critical micelle concentration (CMC) decreased with the increase in the substitution of DEACMS on CMCS, which ranged from 0.013 to 0.042 mg/mL. Upon irradiation under simulated sunlight, the hydrodynamic diameter, morphology, photophysical properties and photolysis were researched by means of dynamic light scattering (DLS), transmission electron microscopy (TEM), UV-vis absorption spectroscopy and fluorescence spectroscopy. Moreover, 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a model pesticide and encapsulated into the CMCS-DEACMS micelles. In these micelle formulations, the release of 2,4-D was promoted upon simulated sunlight irradiation, during which the coumarin moieties were cleaved from the CMCS backbone, resulting in a shift of the hydrophilic–hydrophobic balance and destabilization of the micelles. Additionally, bioassay studies suggested that this 2,4-D contained which micelles showed good bioactivity on the target plant without harming the nontarget plant. Thereby, the light-responsive CMCS-DEACMS micelles bearing photocleavable coumarin moieties provide a smart delivery platform for agrochemicals.

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“…The resulting CMCS-AGE-TSS was used to encapsulate by self-assembling the anthelmintic and insecticidal pesticide Avermectin (AVM), obtaining the AGE-TSS@AVM NPs. The latter demonstrated a better spreadability and adherence to the leaves, slow-release under neutral conditions, increased shelf-life (from 45 to 83 min), and similar insecticidal activity compared to pure AVM [ 31 ].…”

Section: Improving Crop Production Via Nanotechnology-enabled Innovationsmentioning

confidence: 99%

Nano-Enable Materials Promoting Sustainability and Resilience in Modern Agriculture

et al. 2021

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Intensive conventional agriculture and climate change have induced severe ecological damages and threatened global food security, claiming a reorientation of agricultural management and public policies towards a more sustainable development model. In this context, nanomaterials promise to support this transition by promoting mitigation, enhancing productivity, and reducing contamination. This review gathers recent research innovations on smart nanoformulations and delivery systems improving crop protection and plant nutrition, nanoremediation strategies for contaminated soils, nanosensors for plant health and food quality and safety monitoring, and nanomaterials as smart food-packaging. It also highlights the impact of engineered nanomaterials on soil microbial communities, and potential environmental risks, along with future research directions. Although large-scale production and in-field testing of nano-agrochemicals are still ongoing, the collected information indicates improvements in uptake, use efficiency, targeted delivery of the active ingredients, and reduction of leaching and pollution. Nanoremediation seems to have a low negative impact on microbial communities while promoting biodiversity. Nanosensors enable high-resolution crop monitoring and sustainable management of the resources, while nano-packaging confers catalytic, antimicrobial, and barrier properties, preserving food safety and preventing food waste. Though, the application of nanomaterials to the agri-food sector requires a specific risk assessment supporting proper regulations and public acceptance.

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Carboxymethyl chitosan grafted trisiloxane surfactant nanoparticles with pH sensitivity for sustained release of pesticide

Cited by 77 publications

References 54 publications

A comparative study on physicochemical and micellar solubilization performance between monoglucosyl rebaudioside A and rebaudioside A

A comparative study on physicochemical and micellar solubilization performance between monoglucosyl rebaudioside A and rebaudioside A

Coumarin-Containing Light-Responsive Carboxymethyl Chitosan Micelles as Nanocarriers for Controlled Release of Pesticide

Nano-Enable Materials Promoting Sustainability and Resilience in Modern Agriculture

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