Carboxylic Acids from Herbs of Veronica austriaca, V. cuneifolia, and V. armena

Ковалева, А. М.; Ilina, Тetiana; Osmachko, Alina; Коshovyi, Oleh; Grudko, I. V.

doi:10.1007/s10600-020-03238-1

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…The MS conditions were as follows: the ionization voltage 70 eV; the acquisitions scan mass range of 40-500 amu; the ion source temperature 230 ˚C at a sampling rate of 1.0 scan/s. Identification of methyl esters of acids was performed based on the calculation of the equivalent length of the aliphatic chain (ECL) by using data from the mass spectra libraries NIST 05 and Willey 2007 in combination with programs for identifying AMDIS and NIST; the retention time of esters was also compared with the retention time of standard compounds (Sigma) [31,32].…”

Section: Identification and Comparative Content Determination Of Carb...mentioning

confidence: 99%

Carboxylic acids in the flowers of Veronica spicata L. and Veronica incana L.

Ковалева

Raal

Ilina

et al. 2022

SR: PS

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In the Ukrainian flora, species of Veronica L. genus (Plantaginaceae Juss.) are classified into 8 sections. Among the representatives of Pseudolysimachion W. D. J. Koch section in the Kharkiv region, Veronica spicata L. (spike speedwell) and Veronica incana L. (Veronica spicata L. subsp. incana (L.) Walters, silver speedwell) are common. Plants are used for the treatment of upper respiratory tract diseases, malignant neoplasms, gastrointestinal tract and genitourinary system disorders, diabetes mellitus. The aim of the research was to study the carboxylic acids of flowers of Veronica spicata L. and Veronica incana L. Materials and methods. The objects of the research were flowers of Veronica spicata L. and Veronica incana L., collected in the flowering stage in the Botanical Garden of Karazin University (Kharkiv, Ukraine) in summer 2018. The study of carboxylic acid composition was performed by chromatography-mass spectrometry on a 6890N MSD/DS Agilent Technologies chromatograph with a 5973N mass spectrometric detector. Identification of methyl esters of acids was performed using data from the mass spectrum libraries NIST 05 and Willey 2007 in a combination with programs for the identification of AMDIS and NIST; also, their retention time and the retention times of standard compounds were compared. Results. In Veronica incana L. flowers, 37 carboxylic acids were identified and quantified, constituting 1.05 %. In Veronica spicata L. flowers, 32 carboxylic acids were identified and quantified, the total content of which was 2.75 %. Conclusions. A higher carboxylic acid content was established in the flowers of Veronica spicata L. The fatty acid composition of Veronica incana L. flowers is characterized by a comparable content of saturated and unsaturated acids, while in Veronica spicata L. flowers, unsaturated fatty acids prevail over saturated fatty acids. The content of aromatic acids in the flowers of studied species was comparable. The characteristic carboxylic acids in the flowers of Veronica incana L. are oxalic, 3-hydroxy-2-methylglutaric, pentadecanoic, heneicosanoic, tricosanic,4-hydroxybenzoic, 4-methoxybenzoic and 3,4-dimethoxybenzoic acids; in the flowers of Veronica spicata L. – 2-hydroxy-3-methylglutaric, α-furanic and homovanillic acids

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Section: Identification and Comparative Content Determination Of Carb...mentioning

confidence: 99%

Carboxylic acids in the flowers of Veronica spicata L. and Veronica incana L.

Ковалева

Raal

Ilina

et al. 2022

SR: PS

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“…Such valuable secondary metabolites of fruits as well as leaves, flowers or shoots of the Vitex representatives as terpenoids or phenolic compounds were within the scientific scope of many researchers [1,2,5,6]. A lot of compounds of primary biosynthesis including carbohydrates, carboxylic acids, vitamins, amino acids also possess the valuable pharmacological properties [7,8] and deserve considerable attention. There is a lack of scientific data on contents of carboxylic acids in the flowering shoots of the Vitex species.…”

Section: Introductionmentioning

confidence: 99%

“…Carboxylic acids are diverse in their structures as well as in pharmacological effects [7,10]. Ferulic, benzoic, p-hydroxybenzoic, phydroxycinnamic, citric, vanillic, and succinic acids were recognized by many researchers as pharmacologically active substances [11,15].…”

Section: Introductionmentioning

confidence: 99%

CHROMATOGRAPHIC ANALYSIS OF CARBOXYLIC ACIDS IN THE FLOWERING SHOOTS OF SOME Vitex L. SPECIES

Shanaida

Holenko

2022

AML

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Introduction. The genus Vitex L. counts more than 200 species of shrubs and trees common to subtropical areas of the Earth. Only fruits of Vitex agnus-castus L. are used in official medicine. The aim of our study was to perform the chromatographic analysis of carboxylic acids in the flowering shoots of three Vitex representatives under their cultivation in Ukraine. Materials and Methods. Gas chromatography with mass spectrometry (GC/MS) was applied for the analysis of composition and contents of carboxylic acids in the Vitex agnus-castus L., Vitex negundo L. and Vitex negundo var. cannabifolia (Siebold & Zucc.) Hand.-Mazz. flowering shoots. Results and Discussion. The Vitex agnus-castus raw material contained the most significant amount of short-chained aliphatic acids (2454 mg/kg). Malonic, oxalic, citric, and malic acids noticeably prevailed in all the raw materials. The largest amount of aromatic acids was found in the Vitex negundo var. cannabifolia (3926 mg/kg) flowering shoots. p-Hydroxybenzoic acid dominated among the aromatic acids in the plant raw materials of all species. The most noticeable total content of unsaturated fatty acids was in the Vitex negundo var. cannabifolia (4793 mg/kg). Conclusions. To summarize the contents of valuable carboxylic acids, the obtained results provide the evidence for the development and further pharmacological study of herbal preparations from the flowering shoots of three Vitex species.

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“…It is known that species of the genus Veronica L. contain iridoids [9,10], flavonoids and phenylpropanoids [11], carboxylic acids [12,13].…”

Section: Introductionmentioning

confidence: 99%