Carboxyhemoglobin and Methemoglobin in Asthma

Naples, Robert; Laskowski, D. E.; McCarthy, Kevin; Mattox, Emmea; Comhair, Suzy; Erzurum, Serpil C.

doi:10.1007/s00408-015-9686-x

Cited by 14 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Healthy donor lungs not used for transplantation were used as controls. Serum NO was determined by measure of total NO i.e., nitrite and nitrate as published previously (29, 32). …”

Section: Methodsmentioning

confidence: 99%

Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response

Asosingh

Vasanji²,

Tipton

et al. 2016

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

Angiogenesis is closely linked to and precedes eosinophilic infiltration in asthma. Eosinophils are recruited into the airway by chemoattractant eotaxins, which are expressed by endothelial cells, smooth muscles cells, epithelial cells, and hematopoietic cells. We hypothesized that bone marrow-derived proangiogenic progenitor cells that contain eotaxins contribute to the initiation of angiogenesis and inflammation in asthma. Whole lung allergen challenge of atopic asthma patients revealed vascular activation occurs within hours of challenge, and prior to airway inflammation. The eotaxin receptor CCR3 was expressed at high levels on submucosal endothelial cells in patients and murine model of asthma. Exvivo exposure of murine endothelial cells to eotaxins induced migration and angiogenesis. In mechanistic studies, wildtype mice transplanted with eotaxin-1/2 deficient bone marrow had markedly less angiogenesis and inflammation in an atopic asthma model, while adoptive transfer of proangiogenic progenitor cells from wildtype mice in an atopic asthma model into the eotaxin-1/2 deficient mice led to angiogenesis and airway inflammation. The findings indicate that TH2-promoting hematopoietic progenitor cells are rapidly recruited to the lung upon allergen exposure and release eotaxins that coordinately activate endothelial cells, angiogenesis, and airway inflammation.

show abstract

“…Healthy donor lungs not used for transplantation were used as controls. Serum NO was determined by measure of total NO i.e., nitrite and nitrate as published previously (29, 32). …”

Section: Methodsmentioning

confidence: 99%

Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response

Asosingh

Vasanji²,

Tipton

et al. 2016

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…These were excluded from analyses given the limited number of data points. There is suggestion SpCO may be elevated in asthma and chronic obstructive pulmonary disease, but literature remains unclear on which conditions are associated with elevated carboxyhemoglobin [26,27]. We do not expect a relationship between SpCO and hypertension or supraventricular tachycardia.…”

Section: Discussionmentioning

confidence: 71%

Carboxyhemoglobin Levels Induced by Cigarette Smoking Outdoors in Smokers

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Because MetHb lacks oxygen carrying capability, methemoglobinemia is regarded as a causative factor of hypoxia. The body is equipped with methemoglobin reductase to eliminate MetHb from the blood ( 22 ). The amplitude of changes in MetHb during urologic surgery is also rather small compared to methemoglobinemia, which causes cyanosis.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Smoking on the Variations in Carboxyhemoglobin and Methemoglobin During Urologic Surgery

et al. 2017

View full text Add to dashboard Cite

Introduction:Surgery is supposed to modulate the production of carbon monoxide by the reduction of heme oxygenase activity or transcriptional regulation of inducible heme oxygenase. On the other hand, the inhalation of tobacco smoke can substantially raise the level of carboxyhemoglobin in the blood. Furthermore, methemoglobin is maintained at a constant level. However, excessive production of methemoglobin relative to total methemoglobin reductase activity results in methemoglobin increase.Aim:The aim of our study was to investigate the perioperative variations of carboxyhemoglobin and methemoglobin during urologic surgeries, and at the same time to evaluate the changes in methemoglobin as a possible indicator of nitric oxide generation. Our second aim was to evaluate the effect of preoxygenation on the level of carboxyhemoglobin and methemoglobin and the influence of blood transfusion on their changes.Material and methods:The study included 30 patients scheduled for urologic surgery under general endotracheal anesthesia, aged 18–60 years without any history of respiratory disease, divided into two groups. The study group comprised patients who were smoking cigarettes or tobacco pipe, while the control group included non-smokers. In both groups carboxyhemoglobin (COHb) and methemoglobin (MetHb) levels were determined preoperatively, after preoxygenation, and postoperatively.Results:COHb levels were decreased postoperatively in both groups. The average values of COHb between the two groups were statistically significantly different (p=0.00). MetHb levels increased postoperatively in the group of smokers and decreased in the group of non-smokers. There were no statistically significant differences in the average postoperative MetHb levels between the two groups.Conclusion:Changes in carboxyhemoglobin and methemoglobin concentrations in arterial blood occur during urologic surgery, although these amplitudes are small when compared with carbon monoxide intoxication and methemoglobinemia. It is likely that organ perfusion and functions are affected by these monoxide gas mediators during urologic surgery.

show abstract

Carboxyhemoglobin and Methemoglobin in Asthma

Cited by 14 publications

References 13 publications

Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response

Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response

Carboxyhemoglobin Levels Induced by Cigarette Smoking Outdoors in Smokers

The Influence of Smoking on the Variations in Carboxyhemoglobin and Methemoglobin During Urologic Surgery

Contact Info

Product

Resources

About