Carbonic anhydrase inhibitory properties of novel benzylsulfamides using molecular modeling and experimental studies

Synthesis of N-alkyl (aril)-tetra pyrimidine thiones and investigation of their human carbonic anhydrase I and II inhibitory effects

“…[33][34][35][36][37] . Two cytosolic human CA isoforms (hCA I, and II) are widespread throughout the human body and are drug targets for clinically used diuretics, anticonvulsants and antiglaucoma drugs [38][39][40][41][42] . Five of the vertebrate CA isoforms are cytosolic (CA I, II, III, VII and XIII), some others (CA IV, IX, XII, XIV and XV) are membrane bound, two isoenzymes (CA VA and VB) are mitochondrial, and one isoform (CA VI) is secreted in saliva [43][44][45][46][47][48] .…”

Synthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase

“…Also, this CA family has molecular kinetic and different properties, oligomeric rearrangements and expression levels, as well as various abilities to respond to different inhibitory classes [36][37][38] . According to the known cellular localization, some of them are cytosolic (CA I, CA II, CA III, CA VII and CA XIII), some other CA isoenzymes are membrane bound (CA IV, CA IX, CA XII and CA XIV), two of CAs are mitochondrial (CA VA and CA VB) and one of CAs is salivary (CA VI) [39][40][41][42] . CA XV is not synthesized in humans and other primates and is abundantly found in rodents and other vertebrates as an isoform.…”

Synthesis and inhibitory properties of some carbamates on carbonic anhydrase and acetylcholine esterase

“…Carbonic anhydrases are mainly Zn 2+ containing metalloenzymes that catalyze the reversible interconversion of CO 2 and H 2 O to HCO 3 À and a proton (H + ) for the hydration reaction or consumes one equivalent of H + for the dehydration reaction [15][16][17][18][19][20] . This makes these isoenzymes crucial for many physiological and biochemical processes including electrolyte secretion, respiration, pH and CO 2 homeostasis, bone calcification, ureagenesis, gluconeogenesis, tumorigenicity, lipogenesis, transport of CO 2 / HCO 3 À between metabolizing tissues and the lungs, and some other physiologic or pathologic processes [21][22][23][24][25] . This enzyme class is present either in eukaryote or prokaryote cells.…”