Carbonic anhydrase inhibitors:in vitroinhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids

Kinetic andin silicoanalysis of thiazolidin-based inhibitors of α-carbonic anhydrase isoenzymes

“…Although various carbonic anhydrase inhibitors have been identified up to now, it is critically important to explore further classes of potent CAIs in order to detect compounds with a different inhibition profile to find novel applications for the inhibitors of these widespread enzymes [35][36][37][38][39][40] .…”

<i>In Vivo</i> Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme

“…8 However, many studies show that various flavonoids strongly inhibit the CA isozymes under in vitro conditions. 16,17 In the previous study conducted by Ekinci et al 17 and co-workers, it was determined that quercetin, apigenin, luteolin and morin which are a flavanone inhibited human CA I and II isozyme with K i values 3.6-2.4 µM; 4.1-2.7 µM; 2.2-0,74 µM and 12.8-4.4 µM, respectively.…”

“…12 In addition, researchers have frequently reported the effects of heavy metal ions on different enzymes in previous years and inhibition effect of heavy metals on metabolically imported enzyme such as CA 21 , glucose 6-phopsphate dehydrogenase 22 , cytochrome P450 reductase 23 , glutathione S-transferase 24 have been determined. For example, Ekinci et al 17 and co-workers mentions the inhibition effects of lead, copper, cobalt heavy metals on cytosolic human CA I and II enzyme activities. 21 Heavy metals have enzyme inhibition property by establishing a bond with the sulfhydryl groups of proteins.…”

Inhibition studies of quinazoline-sulfonamide derivatives against the γ-CA (PgiCA) from the pathogenic bacterium,Porphyromonas gingivalis

“…PgiCA and PgiCAb were shown to possess a significant catalytic activity for the reaction that converts the CO 2 [20][21][22][23] . Sulfonamides and their bioisosteres sulfamates are the most well known and extensively studied CA inhibitors [8][9][10][11][12][13][14][15][16][17][18] . Quinazolines are 1,3-benzodiazine derivatives representing an important class among heterocyclic compounds of medical, biological, and industrial interest.…”

“…The inhibition of CAs is well-known processes, with most types of inhibitors binding to the metal center. Sulfonamides and their bioisosteres, such as sulfamates and sulfamides are the most investigated types of organic inhibitors, having various biomedical applications as diuretics or as drugs for the treatment or prevention of a variety of disorders such as anti-glaucoma drugs, anti-convulsants, anti-obesity, anti-cancer, anti-pain and antiinfective agents [15][16][17][18] . Recently, our group reported a new poorly characterized enzyme belonging to the g-CA, the Porphyromonas gingivalis.…”