Carbonate Apatite Bone Replacement

Ishikawa, Kunio

doi:10.1007/978-3-319-12460-5_8

Cited by 12 publications

(15 citation statements)

References 15 publications

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“…The carbonate content of carbon apatite depends on processing type and can reach 4-8 wt.%, which is similar to that of bone (4-6 wt.%). 18 Although carbonate apatite can be regarded as bone apatite, its powder form cannot be used directly as a bone substitute. The direct use of the powder forms of carbonate apatite as a bone substitute would induce inflammatory response upon implantation.…”

Section: Main Characteristics Of Carbonate Apatitementioning

confidence: 99%

“…Such materials include calcium carbonate; calcium phosphate; and phosphate compounds, such as zinc phosphate. 9,18 Matsuura et al 21 attempted to identify the optimal carbonate content of bone grafts. They found that over long-term observation (24 weeks after implantation), the new bone formation area ratio obtained with grafts with 6 wt.% carbonate was higher than obtained with grafts with different carbonate contents.…”

Section: Development Of Carbonate Apatite As a Synthetic Bone Graftmentioning

confidence: 99%

“…The resorbability of carbonate apatite by osteoclasts is higher than that of sintered HAp in physiological or acidic environments. 18 The high chemical reactivity in weak acids and resorption capability by bone tissue of carbonate apatite can be attributed to the carbonate content within the apatite lattice. 3 The responses of osteoblasts to carbonate apatite can be used as an indicator of osteoconductivity because it determines the turnover of materials within bone tissue.…”

Section: Physiological Response Of Cells and Tissues To Carbonate Apamentioning

confidence: 99%

“…3 The responses of osteoblasts to carbonate apatite can be used as an indicator of osteoconductivity because it determines the turnover of materials within bone tissue. 18 Ayukawa et al 9 found that in contrast to HAp, carbonate apatite can intensively bind with bone tissue without inducing fibrotic tissue formation. By contrast, Nagai et al 16 found no difference in cell count until the 7 th day.…”

Section: Physiological Response Of Cells and Tissues To Carbonate Apamentioning

confidence: 99%

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The potential of carbonate apatite as an alternative bone substitute material

Rahyussalim¹,

Supriadi²,

Marsetio³

et al. 2019

Med J Indones

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Bone reconstructive surgery has become a common procedure, and bone transplantation has become the second most frequently performed tissue transplantation procedure worldwide. Therefore, the need for bone substitute materials has increased. Artificial bone substitutes exhibit osteoconductive properties and feature several advantages, including abundant resources, low cost, and low donor site morbidity. Carbonate apatite (CO3Ap) is a calcium phosphate ceramic that can be used as a synthetic bone graft. The carbonate content of this ceramic is similar to that of bone apatite. In this review, we show that carbonate apatite can be degraded given its chemical reactivity in a weakly acidic environment and through osteoclast resorption. Moreover, it is osteoconductive and promotes bone tissue formation without fibrotic tissue formation. Additionally, microstructural analysis revealed that new bone tissue is formed within the bone graft itself.

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Section: Main Characteristics Of Carbonate Apatitementioning

confidence: 99%

Section: Development Of Carbonate Apatite As a Synthetic Bone Graftmentioning

confidence: 99%

Section: Physiological Response Of Cells and Tissues To Carbonate Apamentioning

confidence: 99%

Section: Physiological Response Of Cells and Tissues To Carbonate Apamentioning

confidence: 99%

See 2 more Smart Citations

The potential of carbonate apatite as an alternative bone substitute material

Rahyussalim¹,

Supriadi²,

Marsetio³

et al. 2019

Med J Indones

View full text Add to dashboard Cite

show abstract

“…The fabricated CO 3 Ap block thus shows properties similar to the properties of the bone. In contrast to sintered HAp, which is not resorbed by osteoclasts, CO 3 Ap blocks are resorbed by osteoclasts and they can serve as a new bone replacement [9,29,30,31]. Furthermore, CO 3 Ap blocks were found to upregulate osteoblastic differentiation and they showed a much higher osteoconductivity than HAp [32].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Histological Evaluation of Porous Carbonate Apatite Block from Gypsum Block Containing Spherical Phenol Resin as a Porogen

et al. 2019

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The utility of carbonate apatite (CO3Ap) as a bone substitute has been demonstrated. The feasibility of fabricating macroporous CO3Ap was evaluated through a two-step dissolution–precipitation reaction using gypsum as the precursor and spherical phenol resin as the porogen. Porogen-containing gypsum was heated to burn out the porogen and to fabricate macroporous structures. Gypsum transformed into CaCO3 upon immersion in a sodium carbonate solution, while maintaining its macroporous structure. Next, CaCO3 transformed into CO3Ap upon immersion in a Na2HPO4 solution while maintaining its macroporous structure. The utility of the macroporous CO3Ap for histologically reconstructing bone defects was evaluated in rabbit femurs. After 4 weeks, a much larger bone was formed inside the macroporous CO3Ap than that inside non-macroporous CO3Ap and macroporous hydroxyapatite (HAp). A larger amount of bone was observed inside non-macroporous CO3Ap than inside macroporous HAp. The bone defects were completely reconstructed within 12 weeks using macroporous CO3Ap. In conclusion, macroporous CO3Ap has good potential as an ideal bone substitute.

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Effects of the carbonate content in carbonate apatite on bone replacement

Deguchi

Nomura

Tsuchiya

et al. 2021

J Tissue Eng Regen Med

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Carbonate apatite (CO 3 Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO 3 content in CO 3 Ap on the replacement by new bone were studied by fabricating CO 3 Ap granules containing 0.9-8.3 wt% of CO 3 . The dissolution rate of CO 3 Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO 3 Ap granules containing a larger amount of CO 3 . Histological analyses demonstrated the rapid resorption in CO 3 Ap and replacement by natural bone tissue when the CO 3 content was increased. Therefore, the CO 3 content in CO 3 Ap is a key factor that influences the replacement of the bone tissue. K E Y W O R D S carbonate apatite, carbonate content, osteoclastic resorption, resorbability 1 | INTRODUCTION Carbonate apatite [CO 3 Ap: Ca 10-a (PO 4 ) 6-b (CO 3 ) c ] is replaced by new bone, unlike hydroxyapatite [HAp: Ca 10 (PO 4 ) 6 (OH) 2 ], which is

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Carbonate Apatite Bone Replacement

Cited by 12 publications

References 15 publications

The potential of carbonate apatite as an alternative bone substitute material

The potential of carbonate apatite as an alternative bone substitute material

Fabrication and Histological Evaluation of Porous Carbonate Apatite Block from Gypsum Block Containing Spherical Phenol Resin as a Porogen

Effects of the carbonate content in carbonate apatite on bone replacement

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