Effects of the carbonate content in carbonate apatite on bone replacement

Deguchi, Kaai; Nomura, Shunsuke; Tsuchiya, Akira; Takahashi, Ichiro; Ishikawa, Kunio

doi:10.1002/term.3270

Cited by 15 publications

(7 citation statements)

References 31 publications

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“…The results show that the nanocomposites were enriched with Ca and P, the main components of HCA in bone, as observed in the increased atomic percentages of Ca and P on the surfaces of nanocomposites after SBF incubation ( Table 3 ). Additionally, the resulting Ca/P ratios after SBF treatment were higher than the stoichiometric Ca/P ratio of hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), a typical artificial bone [ 73 ], which is between 1.67 and 1.50. The increased Ca/P ratio in the nanocomposite could be due to the carbonate ion substitution in the HCA structure [ 74 ].…”

Section: Resultsmentioning

confidence: 99%

Sol-Gel Derived Gelatin–Bioactive Glass Nanocomposite Biomaterials Incorporating Calcium Chloride and Calcium Ethoxide

Arambula-Maldonado,

Mequanint

2024

Polymers

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Calcium-containing organic–inorganic nanocomposites play an essential role in developing bioactive bone biomaterials. Ideally, bone substitute materials should mimic the organic–inorganic composition of bone. In this study, the roles of calcium chloride (CaCl2) and calcium ethoxide (Ca(OEt)2) were evaluated for the development of sol-gel-derived organic–inorganic biomaterials composed of gelatin, bioactive glass (BG) and multiwall carbon nanotubes (MWCNTs) to create nanocomposites that mimic the elemental composition of bone. Nanocomposites composed of either CaCl2 or Ca(OEt)2 were chemically different but presented uniform elemental distribution. The role of calcium sources in the matrix of the nanocomposites played a major role in the swelling and degradation properties of biomaterials as a function of time, as well as the resulting porous properties of the nanocomposites. Regardless of the calcium source type, biomineralization in simulated body fluid and favorable cell attachment were promoted on the nanocomposites. 10T1/2 cell viability studies using standard media (DMEM with 5% FBS) and conditioned media showed that Ca(OEt)2-based nanocomposites seemed more favorable biomaterials. Collectively, our study demonstrated that CaCl2 and Ca(OEt)2 could be used to prepare sol-gel-derived gelatin–BG–MWCNT nanocomposites, which have the potential to function as bone biomaterials.

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Section: Resultsmentioning

confidence: 99%

Sol-Gel Derived Gelatin–Bioactive Glass Nanocomposite Biomaterials Incorporating Calcium Chloride and Calcium Ethoxide

Arambula-Maldonado,

Mequanint

2024

Polymers

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“…43 The higher the carbonate content in a biomaterial, the higher the osteoclastic resorption at the biomaterial's surface. 44 Osteoclasts release chemokines which are activating osteoblasts by cell-to-cell interactions. 43 Moreover, a higher content of carbonate promoted cell proliferation of murine preosteoblasts and enhanced the calcium release.…”

Section: Discussionmentioning

confidence: 99%

“…Carbonate has shown to be a determining factor for the osteoconductivity of apatites 43 . The higher the carbonate content in a biomaterial, the higher the osteoclastic resorption at the biomaterial's surface 44 . Osteoclasts release chemokines which are activating osteoblasts by cell‐to‐cell interactions 43 .…”

Section: Discussionmentioning

confidence: 99%

Preclinical evaluation of a new synthetic carbonate apatite bone substitute on periodontal regeneration in intrabony defects

Imber,

Roccuzzo

et al. 2023

J of Periodontal Research

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ObjectiveTo evaluate the potential of a novel synthetic carbonate apatite bone substitute (CO3Ap‐BS) on periodontal regeneration.BackgroundThe use of various synthetic bone substitutes as a monotherapy for periodontal regeneration mainly results in a reparative healing pattern. Since xenografts or allografts are not always accepted by patients for various reasons, a synthetic alternative would be desirable.MethodsAcute‐type 3‐wall intrabony defects were surgically created in 4 female beagle dogs. Defects were randomly allocated and filled with CO3Ap‐BS (test) and deproteinized bovine bone mineral (DBBM) or left empty (control). After 8 weeks, the retrieved specimens were scanned by micro‐CT, and the percentages of new bone, bone substitute, and soft tissues were evaluated. Thereafter, the tissues were histologically and histometrically analyzed.ResultsHealing was uneventful in all animals, and defects were present without any signs of adverse events. Formation of periodontal ligament and cementum occurred to varying extent in all groups without statistically significant differences between the groups. Residues of both bone substitutes were still present and showed integration into new bone. Histometry and micro‐CT revealed that the total mineralized area or volume was higher with the use of CO3Ap‐BS compared to control (66.06 ± 9.34%, 36.11 ± 6.40%; p = .014, or 69.74 ± 2.95%, 42.68 ± 8.68%; p = .014). The percentage of bone substitute surface covered by new bone was higher for CO3Ap‐BS (47.22 ± 3.96%) than for DBBM (16.69 ± 5.66, p = .114).ConclusionsCO3Ap‐BS and DBBM demonstrated similar effects on periodontal regeneration. However, away from the root surface, more new bone, total mineralized area/volume, and higher osteoconductivity were observed for the CO3Ap‐BS group compared to the DBBM group. These findings point to the potential of CO3Ap‐BS for periodontal and bone regeneration.

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“…One of the CaPs that stood out, based on its structural similarity to hydroxyapatite and extraordinary biological attributes, is octacalcium phosphate (OCP) 6 . An additional advantage of OCP is its ability to convert to the thermodynamically more stable phase (hydroxyapatite), both in vitro and in vivo 7 . It is generally synthesized through the precipitation of various aqueous solutions containing calcium and phosphate ion source or via the hydrolysis of -tricalcium phosphate ( -TCP) 8 , 9 or brushite (dicalcium phosphate dihydrate, DCPD) 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Fusion and classification algorithm of octacalcium phosphate production based on XRD and FTIR data

Nascimben,

Kovrlija,

Locs

et al. 2024

Sci Rep

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The present manuscript tested an automated analysis sequence to provide a decision support system to track the OCP synthesis from $$\alpha$$ α -TCP over time. Initially, the XRD and FTIR signals from a hundredfold scaled-up hydrolysis of OCP from $$\alpha$$ α -TCP were fused and modeled by the curve fitting based on the significantly established maxima from the literature and nine features extracted from the fitted shapes. Afterward, the analysis sequence enclosed the machine learning techniques for feature ranking, spatial filtering, and dimensionality reduction to support the automatic recognition of the synthesis stages. The proposed analysis pipeline for OCP identification might be the foundation for a decision support system explicitly targeting OCP synthesis. Future projects will exploit the suggested methodology for pinpointing the OCP production over time (including the intermediary phases present in the OCP formation) and for evaluating whether biological variables might be merged with biomaterial properties to build a unified model of tissue response to the implant.

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Effects of the carbonate content in carbonate apatite on bone replacement

Cited by 15 publications

References 31 publications

Sol-Gel Derived Gelatin–Bioactive Glass Nanocomposite Biomaterials Incorporating Calcium Chloride and Calcium Ethoxide

Sol-Gel Derived Gelatin–Bioactive Glass Nanocomposite Biomaterials Incorporating Calcium Chloride and Calcium Ethoxide

Preclinical evaluation of a new synthetic carbonate apatite bone substitute on periodontal regeneration in intrabony defects

Fusion and classification algorithm of octacalcium phosphate production based on XRD and FTIR data

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