Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats

Öztürk, Feral; Uçar, Muharrem; Ozturk, I. Cetin; Vardı, Nigar; Batçıoğlu, Kadir

doi:10.1016/s0090-4295(03)00255-3

Cited by 166 publications

(133 citation statements)

References 14 publications

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“…Among the models of the liver damage, CCl 4 is a model of intoxication, widely used because it is able to induce oxidative stress and liver injury in experimental animals (Cemek et al 2012), increasing lipid peroxidation and protein oxidation in the liver, resulting in damage generalized to the membrane (Ozturk et al 2003). Thus, it is believed that liver injury CCl 4 -induced can be reduced by an antioxidant (Fujisawa et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant activity of grapevine leaves extracts (Vitis labrusca) in liver of Wistar rats

Schaffer

Wohlenberg

Medeiros

et al. 2016

An. Acad. Bras. Ciênc.

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The aim of this study was to evaluate the hepatoprotection of organic and conventional grapevine leaves extract (Vitis labrusca). The total polyphenol content and the isolate polyphenols by HPLC were evaluate. The animals received intraperitoneal injections of saline or extracts (conventional or organic -30 mg/kg) for 14 days. On day 15, the rats received carbon tetrachloride (CCl 4 ) or mineral oil (i.p.). After 4h, the animals were euthanized. The analysis of the liver enzymes activity (AST, ALT, GGT) was performed using serum, obtained by blood and the levels of lipid peroxidation (TBARS), protein oxidation (carbonyl), and the activity of antioxidant enzymes superoxide dismutase and catalase were analyzed in the liver. The results showed that the organic extract is richer in polyphenol and resveratrol than the conventional one. Both extracts prevent lipid peroxidation and protein oxidation generated by CCl 4 . Moreover, the extracts demonstrated ability to modulate the activity of SOD and CAT, as well as to establish a balance in the ratio of SOD/CAT. We also found that the CCl 4 increased the levels of AST and GGT, and that both extracts prevent this. These results indicate that grapevine leaves extracts, both, organic and conventional, can prevent liver disorders.

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Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant activity of grapevine leaves extracts (Vitis labrusca) in liver of Wistar rats

Schaffer

Wohlenberg

Medeiros

et al. 2016

An. Acad. Bras. Ciênc.

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“…Additionally, CCl 4 causes free toxic radical generation in kidneys [5,6]. Various studies demonstrate that some antioxidants protect the liver and kidney from the oxidative damage induced by CCl 4 [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

et al. 2010

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“…CCl 4 is commonly used for free radical induced liver injury. Liver is not the only target organ of CCl 4 but it also effect several organs like kidneys, lungs, heart, testis, brain and blood [10-12]. Through the investigation of acute CCl 4 induced liver damage in animal models, it is now generally accepted that CCl 4 toxicity results from bioactivation of CCl 4 into trichloromethyl free radical by cytochrome P450 system in liver microsomes and consequently causes lipid peroxidation of membranes that leads to liver injury [13-15].…”

Section: Introductionmentioning

confidence: 99%

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver

et al. 2010

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BackgroundCarbon tetra chloride (CCl4), an industrial solvent, is a hepatotoxic agent and it is the well established animal model for free radical-induced liver injury. The present investigation was carried out to establish the protective effect of natansnin, a novel dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver.ResultsCCl4 significantly increased the levels of lipid peroxides, oxidized glutathione and decreased the levels of reduced glutathione, SOD and CAT. CCl4 induce marked histopathological changes and increase in the levels of apoptotic proteins. CCl4 treatment significantly increased the levels of apoptotic proteins such as caspases-3, PARP, Bax, Bid and cytochrome C and also increased the levels of inflammatory mediators iNos and Cox-2. Natansnin treatment significantly decreased the levels of CCl4 induced apoptotic proteins and inflammatory mediators. Further natansinin treatment significantly inhibited the CCl4 induced apoptosis which was evident form the reduced TUNEL positive cells.ConclusionsIn conclusion, our study demonstrated the protective effect of natansnin against CCl4 induced oxidative stress and cellular degeneration in rat liver tissue. This protective effect of natansnin can be correlated to its direct antioxidant effect.

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Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats

Cited by 166 publications

References 14 publications

Evaluation of antioxidant activity of grapevine leaves extracts (Vitis labrusca) in liver of Wistar rats

Evaluation of antioxidant activity of grapevine leaves extracts (Vitis labrusca) in liver of Wistar rats

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver

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