Carbon source regulation of antibiotic production

Sánchez, Sergio; Chávez, Adán; Forero, Angela; García-Huante, Yolanda; Romero, A.; Sánchez, Martínez; Rocha, Diana; Sánchez, Brenda; Ávalos, Mariana; Guzmán‐Trampe, Silvia; Rodríguez‐Sanoja, Romina; Langley, Elizabeth; Ruiz, Beatriz

doi:10.1038/ja.2010.78

Cited by 228 publications

(173 citation statements)

References 210 publications

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“…The best results in terms of cephalosporin production were obtained using starch as the main source of C and energy. It is consistent with various studies which have suggested that the continuous and gradual hydrolysis of starch can avoid mechanisms of repression and /or inhibition in the production of β-lactam antibiotics that are normally triggered by C sources that are more easily metabolized by the microorganism, such as glucose or glycerol (Alexander et al 2007;Sánchez et al 2010). It has been observed that these easily assimilated sources can lead to an accumulation of intracellular phosphorylated compounds that drastically inhibit the expandase activity, which is the enzyme responsible for the expansion of the penicillin N ring of the β-lactam antibiotics biosynthetic pathway (Martín 2004;Zhu et al 2007).…”

Section: Discussionsupporting

confidence: 91%

“…The presence of certain nutrients in the culture medium, such as the sources of C, N, P, or sulfur S, and salts, as well as the substances of the biosynthetic route can promote the production of CA or CephC (Bussari et al 2008). Glycerol is preferably used as C source for the production of CA, whereas starch is more suitable for the production of CephC (Zhu et al 2007;Sánchez et al 2010). …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of different media for the production of cephalosporins by Streptomyces clavuligerus ATCC 27064

Antonio

Bellão

Corrêa

et al. 2012

Braz. arch. biol. technol.

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The aim of this work was to compare the composition of a complex and soluble culture medium to eight other media described in the literature through the batch cultivation in a conventional bench-scale bioreactor for the production of cephamycin C by a wild strain of Streptomyces clavuligerus. The proposed medium resulted in an antibiotic production 1.5 to 7.5 times higher than the other culture media.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Evaluation of different media for the production of cephalosporins by Streptomyces clavuligerus ATCC 27064

Antonio

Bellão

Corrêa

et al. 2012

Braz. arch. biol. technol.

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“…Malt extract broth (MEB) used in this study as fermentation medium contain malt extract as carbon source and mycological peptone as nitrogen source. Sánchez et al (2010) noted that carbon source has important role on antibiotic production. The pH of broth medium decreased during log phase then stable at stationary phase.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Indonesian Sponge Associated Fungi Against Clinical Pathogenic Multidrug Resistant Bacteria

Sibero¹,

Radjasa²,

Sabdono³

et al. 2018

J App Pharm Sci

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Exploration of new source of antibiotics to combat multidrug-resistant bacteria is urgently needed. Indonesia as archipelago country has a wide variety of marine organisms with potential as source of new antibacterial compounds against MDRO. Aims of the study were to isolate sponge-associated fungi from sponge Cinachyrella sp. collected from Pandang Island, North Sumatera, Indonesia, to screen potential fungi against clinical pathogenic MDR bacteria, to identify the potential fungi; and to determine the best cultivation time for antibacterial production. Nine spongeassociated fungi were successfully isolated. Result of agar plug method showed fungus PDSP 5.7 was the most potential candidate which inhibited ESBL Escherichia coli, Salmonella enterica ser. Typhi, MRSA, and Staphylococcus haemolyticus strain MDR. This fungus had 100% similarity to Trichoderma reesei. In malt extract broth, T. reesei PDSP 5.7 had stationary phase from day 12 to day 18. In addition, the widest antibacterial was performed by extract from day 15. Furthermore, fungal extract showed best antibacterial activity against S. enterica ser. Typhi strain MDR with inhibition value of 14.72 ± 0.07 mm 2 .

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“…Production of secondary metabolites through fermentation is influenced by various environmental factors, including nutrients nitrogen, phosphorus, and carbon sources [11][12][13]. Furthermore, production of valuable metabolites by Streptomyces differs qualitatively and quantitatively depending on the strains used in fermentation as one of the most significantroles as sources of precursors and energies for secondary metabolite production [14].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Medium Composition for Antibacterial Metabolite Production From Streptomyces Sp.

Al-Ghazali

Omran

2017

Asian J Pharm Clin Res

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Objectives: This paper aimed to optimize some essential nutritional components (carbon, nitrogen, and phosphate) of fermentation medium necessary for the production of antibacterial metabolites from Streptomyces sp. Materials and Methods:Streptomyces sp. LH9 previously isolated from desert soil in Karbala Province, Iraq. This strain produced antibiotic against 4 pathogenic bacteria, including Escherichia coli, Staphylococcus aureus, Streptococcus agalagtiae, and Pseudomonas aeruginosa. For optimizing, the essential nutritional requirements such as carbon, nitrogen, and phosphate in fermentation media different concentrations of these sources were used to improve the antibacterial metabolite production.Results: All the studied nutritional parameters were had impacts on the antibacterial metabolite production from Streptomyces sp. LH9. The actinobacterial strain produced a highest antibiotic metabolites when was grown in the fermentation medium supplemented with 2% dextrose (as a sole carbon source), 0.05% peptone (as a sole nitrogen source), and 0.05% K 2 HPO 4 at pH 7 and incubated under optimal conditions; at 30°C with 250 rpm (revolutions/min) agitation for 7 days.Conclusion: Streptomyces sp. LH9 was a good producer for antibacterial against Gram-positive and Gram-negative bacteria, which required simple nutritional supplements in the fermentation medium. Furthermore, could be utilized the industrial waste for improving the production in the most economic manner.

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Carbon source regulation of antibiotic production

Cited by 228 publications

References 210 publications

Evaluation of different media for the production of cephalosporins by Streptomyces clavuligerus ATCC 27064

Evaluation of different media for the production of cephalosporins by Streptomyces clavuligerus ATCC 27064

Antibacterial Activity of Indonesian Sponge Associated Fungi Against Clinical Pathogenic Multidrug Resistant Bacteria

Optimization of Medium Composition for Antibacterial Metabolite Production From Streptomyces Sp.

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