Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

Barras, Alexandre; Sauvage, Félix; Hoon, Ines de; Braeckmans, Kevin; Hua, Dawei; Buvat, Gaëtan; Fraire, Juan C.; Lethien, Christophe; Sebag, J.; Harrington, Michael G.; Abderrahmani, Amar; Boukherroub, Rabah; Smedt, Stefaan De; Szunerits, Sabine

doi:10.1039/d1nh00157d

Cited by 16 publications

(26 citation statements)

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“…15 To better understand the influence of the surface composition of CQDs on the aggregation inhibition of hIAPP, three types of CDQs were prepared using the microwave-assisted hydrothermal method (Fig. 4a): (i) positively charged CQD-pos ( ζ = +32.5 mV) 27 using glucosamine as a carbon precursor with ethylenediamine as a passivating agent (Fig. 4b), (ii) neutral CQD-neut via mixing glucose and hydrofluoric acid to catalyse the dehydration reaction, 19 (iii) negatively charged CQD-neg ( ζ = −24 mV) using glucosamine as a precursor and β-alanine as a surface passivating agent.…”

Section: Resultsmentioning

confidence: 99%

“…19 Mitigation of hIAPP aggregation with 2.8 nm average diameter CQDs (prepared from coal as a carbon precursor) was demonstrated by Koppel et al, showing reduced -sheet content in the presence of CQDs. 15 To better understand the influence of surface composition of CQDs on the aggregation inhibition of hIAPP, three types of CDQs were prepared using the microwave-assisted hydrothermal method (Figure 4a): (i) positively charged CQD-pos (ζ=+32.5 mV) 27 using glucosamine as a carbon precursor with ethylenediamine as a passivating agent (Figure 4b), (ii) neutral CQD-neut via mixing glucose and hydrofluoric acid to catalyse dehydration reaction, 19 (iii) negatively charged CQD-neg (ζ=-24 mV) using glucosamine as a precursor and β-alanine as a surface passivating agent. The particles were of spherical shape Before investigating in more details the possibility that these nanostructures inhibit hIAPP aggregation, the cytotoxic effect of CQD-pos, CQD-neut and CQD-neg using resazurin assay was measured.…”

Section: Inhibitory Effect Of Carbon Quantum Dots On Hiapp and A42 A...mentioning

confidence: 99%

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Anti-aggregation effect of carbon quantum dots on diabetogenic and beta-cell cytotoxic amylin and beta amyloid heterocomplexes

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Inhibitory Effect Of Carbon Quantum Dots On Hiapp and A42 A...mentioning

confidence: 99%

Anti-aggregation effect of carbon quantum dots on diabetogenic and beta-cell cytotoxic amylin and beta amyloid heterocomplexes

et al. 2022

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“…66 Our team provided lately valuable data to this discussion by investigating the effect of different carbon nanocolloids on hIAPP aggregation under diabetic conditions. 4 Three types of CDQs were prepared using the microwave-assisted hydrothermal method: (i) positively charged CQD-pos (ζ = +32.5 mV) 3 using glucosamine as a carbon precursor with ethylenediamine as a passivating agent, (ii) neutral CQD-neut via mixing glucose and hydrofluoric acid to catalyze dehydration reaction, 58 and (iii) negatively charged CQD-neg (ζ = −24.1 ± 1.6 mV) using glucosamine as a precursor and β-alanine as a surface passivating agent. 4 All particles were of spherical shape with an average particle size determined by TEM of 16.8 ± 6.7 nm (CQD-pos), 22.3 ± 5.7 nm (CQD-neut), and 20.8 ± 6.6 nm (CQD-neg).…”

Section: ■ Potential Of Carbon Nanoparticles and Carbon Colloids To I...mentioning

confidence: 99%

“…Different to carbon nanotubes, which generally exhibit higher cytotoxic effects compared to other structures within the carbon family, 71 CQDs seem to be favorable for biological applications due to their good water dispersibility and limited cytotoxicity in vitro, as shown in this Account and related literature. 3,4 In vivo toxicity is the next logical step following cellular level studies to be implemented. CQDs injected in female BALB/C mice was studied over 3 months.…”

Section: ■ Conclusion and Perspectivesmentioning

confidence: 99%

“… Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floatersBarrasA.SauvageF.de HoonI.BraeckmansK.HuaD.BuvatG.FraireJ. C.LethienC.SebagJ.HarringtonM.AbderrahmaniA.BoukherroubR.De SmedtS.SzuneritsS. Barras, A. Sauvage, F. de Hoon, I. Braeckmans, K. Hua, D. Buvat, G. Fraire, J. C. Lethien, C. Sebag, J. Harrington, M. Abderrahmani, A. Boukherroub, R. De Smedt, S. Szunerits, S. Nanoscale Horiz.20216449461 …”

Section: Key Referencesmentioning

confidence: 99%

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Nanoparticles and Nanocolloidal Carbon: Will They Be the Next Antidiabetic Class That Targets Fibrillation and Aggregation of Human Islet Amyloid Polypeptide in Type 2 Diabetes?

2022

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Conspectus Nanotechnology is revolutionizing human medicine. Nanoparticles (NPs) are currently used for treating various cancers, for developing vaccines, and for imaging, and other promises offered by NPs might come true soon. Due to the interplay between NPs and proteins, there is more and more evidence supporting the role of NPs for treating amyloid-based diseases. NPs can induce some conformational changes of the adsorbed protein molecules via various molecular interactions, leading to inhibition of aggregation and fibrillation of several and different amyloid proteins. Though an in depth understanding of such interactions between NPs and amyloid structures is still lacking, the inhibition of protein aggregation by NPs represents a new generation of innovative and effective medicines to combat metabolic diseases such as type 2 diabetes (T2D). Here, we lay out advances made in the field of T2D notably for optimizing protein aggregation inhibition strategies. This Account covers discussions about the current understanding of β-cells, the insulin producing cells within the pancreas, under diabetic conditions, notably increased glucose and fatty acid levels, and the implication of these conditions on the formation of human islet amyloid polypeptide (hIAPP) amylin oligomers and aggregates. Owing to the great potential of carbon nanostructures to interfere with protein aggregation, an important part of this Account will be devoted to the state of the art of therapeutic options in the form of emerging nanomaterials-based amyloidosis inhibitors. Our group has recently made some substantial progress in this regard by investigating the impact of glucose and fatty acid concentrations on hIAPP aggregation and β-cell toxicity. Furthermore, the great potential of carbon nanocolloids in reversing hIAPP aggregation under diabetic conditions will be highlighted as the approach has been validated on β-cell cultures from rats. We hope that this Account will evoke new ideas and concepts in this regard. We give some lead references below on pancreatic β-cell aspects and carbon quantum dots for managing diabetics and nanomedicine related aspects, a topic of interest in our laboratory.

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Functional Carbon Quantum Dots for Ocular Imaging and Therapeutic Applications

Kumar

Sher

Rencus‐Lazar

et al. 2022

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functional groups such as CHO, CO, NH 2 , OH, COOH, COC, CN, NO, SH, or polymer aggregates. [11] Moreover, CDs are considered to be the most recent form of zero-dimensional carbon, with a diameter of less than 10 nm and excellent fluorescent properties. [12] These properties have led to their application in biomedical engineering [13] and sensor technology, [14,15] including heavy metal ion detection, [16] fluorescent labeling and nucleus targeted imaging of cells, [17] targeting of drug delivery for anti-tumor therapy, [18] photovoltaic devices/solar cell, [19] photocatalysts, [20] dye degradation, [21] lubricant additive, [22] supercapacitor, [23] nanoelectronic devices, [24] fuel cells, [25] anti-viral therapy, [26] photodynamic therapy, [27] gene delivery, [28] and disruption of the fibrillation of amyloidogenic peptides, such as Aβ. [29,30] Recently, Shah et al. have investigated the presence of Aβ in aging eyes and its significance in relation to Alzheimer's disease (AD) pathology. [31] They have also discussed clinical studies investigating the in vivo ocular imaging of Aβ and its relationship to brain Aβ burden, as well as therapies that target ocular Aβ. [31] Therefore, the characterization of retinal Aβ is also necessary in order to differentiate it from eye-related diseases.According to the World Health Organization, more than 2.2 billion individuals were affected by some form of visual impairment in 2020, with an estimated 35 million blind individuals. [32][33][34] Among the leading causes of vision loss Carbon quantum dots (CDs) are a class of emerging carbonaceous nanomaterials that have received considerable attention due to their excellent fluorescent properties, extremely small size, ability to penetrate cells and tissues, ease of synthesis, surface modification, low cytotoxicity, and superior water dispersion. In light of these properties, CDs are extensively investigated as candidates for bioimaging probes, efficient drug carriers, and disease diagnostics. Functionalized CDs represent a promising therapeutic candidate for ocular diseases. Here, this work reviews the potential use of functionalized CDs in the diagnosis and treatment of eye-related diseases, including the treatment of macular and anterior segment diseases, as well as targeting Aβ amyloids in the retina.

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Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

Abstract: Common in myopia and aging, vitreous opacities arise from clumped collagen fibers within the vitreous body that cast shadows on the retina, appearing as ‘floaters’ to the patient. Vitreous opacities...

Cited by 16 publications

References 53 publications

Anti-aggregation effect of carbon quantum dots on diabetogenic and beta-cell cytotoxic amylin and beta amyloid heterocomplexes

Anti-aggregation effect of carbon quantum dots on diabetogenic and beta-cell cytotoxic amylin and beta amyloid heterocomplexes

Nanoparticles and Nanocolloidal Carbon: Will They Be the Next Antidiabetic Class That Targets Fibrillation and Aggregation of Human Islet Amyloid Polypeptide in Type 2 Diabetes?

Functional Carbon Quantum Dots for Ocular Imaging and Therapeutic Applications

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