Carbon Nanotube Reinforced Supramolecular Hydrogels for Bioapplications

Mihajlovic, Marko; Mihajlovic, Milos; Dankers, Patricia Y. W.; Masereeuw, Rosalinde; Sijbesma, RP Rint

doi:10.1002/mabi.201800173

Cited by 53 publications

(42 citation statements)

References 56 publications

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“…In another tissue engineering application, CNT‐incorporated PEG hydrogels were prepared to generate electrically conductive biomaterials, as CNTs have useful electrical and thermal conductivity properties. Sijbesma and co‐workers fabricated a NC hydrogel composed of oxidized multiwalled nanotubes embedded in PEGDA as an electrically conductive biomaterial . The presence of CNTs resulted in a decrease in the pore size and the stiffness of the PEGDA hydrogel.…”

Section: Biomedical Applications Of Nanocomposite Hydrogelsmentioning

confidence: 99%

Functional Nanomaterials on 2D Surfaces and in 3D Nanocomposite Hydrogels for Biomedical Applications

Tutar

Motealleh

Khademhosseini

et al. 2019

Adv Funct Materials

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An emerging approach to improve the physicobiochemical properties and the multifunctionality of biomaterials is to incorporate functional nanomaterials (NMs) onto 2D surfaces and into 3D hydrogel networks. This approach is starting to generate promising advanced functional materials such as self‐assembled monolayers (SAMs) and nanocomposite (NC) hydrogels of NMs with remarkable properties and tailored functionalities that are beneficial for a variety of biomedical applications, including tissue engineering, drug delivery, and developing biosensors. A wide range of NMs, such as carbon‐, metal‐, and silica‐based NMs, can be integrated into 2D and 3D biomaterial formulations due to their unique characteristics, such as magnetic properties, electrical properties, stimuli responsiveness, hydrophobicity/hydrophilicity, and chemical composition. The highly ordered nano‐ or microscale assemblies of NMs on surfaces alter the original properties of the NMs and add enhanced and/or synergetic and novel features to the final SAMs of the NM constructs. Furthermore, the incorporation of NMs into polymeric hydrogel networks reinforces the (soft) polymer matrix such that the formed NC hydrogels show extraordinary mechanical properties with superior biological properties.

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Section: Biomedical Applications Of Nanocomposite Hydrogelsmentioning

confidence: 99%

Functional Nanomaterials on 2D Surfaces and in 3D Nanocomposite Hydrogels for Biomedical Applications

Tutar

Motealleh

Khademhosseini

et al. 2019

Adv Funct Materials

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“…PNIPAAm/PDMA refers to a gel consists of a poly(N‐isopropylacrylamide) (PNIPAm) moiety and a grafted poly(N,N ‐dimethylacrylamide) (PDMA) sequences. Reproduced with permission from the literatures [ 8,11,15–28 ]…”

Section: Aggregated Structures Used In Fabricating Functional Hydrogelsmentioning

confidence: 99%

“…For example, carbon nanotubes are widely used to fabricate hydrogel composite due to their unique properties, such as electrical conductivity, high mechanical strength, and low mass density. [ 18 ] By incorporating 3 wt% of carbon nanotubes into hydrogels leads to an increase of 358% in electrical conductivity and an increase of 80% in toughness at the same time. Another example is that, by embedding negatively charged unilamellar titanate nanosheets with a quasi‐crystalline structural ordering into a polymer network, the resultant hydrogel shows anisotropic optical and mechanical performance.…”

Section: Aggregated Structures Used In Fabricating Functional Hydrogelsmentioning

confidence: 99%

Aggregated structures and their functionalities in hydrogels

Cui

Gong

2021

Aggregate

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Biological soft tissues and hydrogels belong to the same category of soft and wet matter. Both of them are composed of polymer network and a certain amount of water, and permeable to small molecules. Biological tissues possess elaborated structures and exhibit outstanding functionalities. On the other hand, hydrogels are usually amorphous with poor functionality. In recent years, various hydrogels with robust functionalities have been developed by introducing aggregated structures into the gel networks, widely extend their applications in diverse fields, such as soft actuators, biological sensors, and structural biomaterials. Four strategies are usually used to fabricate aggregated structure into hydrogels, including molecular self‐assembling, microphase separation, crystallization, and inorganic additives. Different aggregated structures entail the gel very different functionalities. A simple aggregated structure is able to bring multiple functionalities and a combination of mechanical performances of the hydrogels. In this review, we describe the strategies used to construct aggerated structure in hydrogels and discuss about the close relation between the aggregated structure and functionality. We also highlight the role of nonequilibrium aggregated structure in fabricating hydrogels with dynamic memorizing‐forgetting behavior and point out the remaining challenges.

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“…CNTs are one of the ideal and favorable materials used for designing novel polymer composites [ 211 ]. Many authors focused on the progress of composite materials fabrication-integrating CNTs to enhance its applications in biomedical field [ 212 , 213 , 214 , 215 , 216 ].…”

Section: Nanobiomaterialsmentioning

confidence: 99%

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

et al. 2020

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One of the most important ideas ever produced by the application of materials science to the medical field is the notion of biomaterials. The nanostructured biomaterials play a crucial role in the development of new treatment strategies including not only the replacement of tissues and organs, but also repair and regeneration. They are designed to interact with damaged or injured tissues to induce regeneration, or as a forest for the production of laboratory tissues, so they must be micro-environmentally sensitive. The existing materials have many limitations, including impaired cell attachment, proliferation, and toxicity. Nanotechnology may open new avenues to bone tissue engineering by forming new assemblies similar in size and shape to the existing hierarchical bone structure. Organic and inorganic nanobiomaterials are increasingly used for bone tissue engineering applications because they may allow to overcome some of the current restrictions entailed by bone regeneration methods. This review covers the applications of different organic and inorganic nanobiomaterials in the field of hard tissue engineering.

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Carbon Nanotube Reinforced Supramolecular Hydrogels for Bioapplications

Cited by 53 publications

References 56 publications

Functional Nanomaterials on 2D Surfaces and in 3D Nanocomposite Hydrogels for Biomedical Applications

Functional Nanomaterials on 2D Surfaces and in 3D Nanocomposite Hydrogels for Biomedical Applications

Aggregated structures and their functionalities in hydrogels

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

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