Carbon Nanotube Immobilized Electrode Using Amphiphilic Phospholipid Polymer with Anti‐fouling and Dispersion Property for Electrochemical Analysis

Abstract

A carbon nanotube (CNT)‐modified electrode was fabricated by dropping a dispersion of multi‐walled CNTs in water‐soluble and amphiphilic phospholipid polymer with both dispersing ability and anti‐biofouling property onto a Au electrode. A poly(2‐methacryloyloxyethyl phosphorylcholine‐co‐n‐butyl methacrylate) (PMB) composed from 50 mol% of 2‐methacryloxylethyl phosphorylcholine and 50 mol% of n‐butyl methacrylate (PMB50) was used as dispersing reagent for CNTs. The dispersion of water‐insoluble material by PMB50 and its antifouling effects in electrochemical analysis were investigated. The CNT‐modified electrode showed an anodic peak potential that was shifted negatively and an increase in the current value for the electrolytic oxidation of nicotinamide adenine dinucleotide. In addition, the charge on PMB50 did not inhibit the electrochemical reaction of the redox compounds K3[Fe(CN)6], [Ru(NH3)6]Cl3, and hydroxymethylferrocene. Cyclic voltammetry of K3[Fe(CN)6] in 4 % bovine serum albumin (BSA) using a bare Au electrode, the anodic peak current was reduced to 47 % of that without BSA. In contrast, the antifouling effect of the PMB50‐coated electrode meant that the current was only reduced to 70 % of that without BSA.

Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information

“…Therefore, it is necessary to employ protective mechanisms to minimize these effects. Polyethylene glycol (PEG) and its derivatives [ 143 ], zwitterionic polymers [ 142 , 144 ], amphiphilic phospholipid polymers [ 145 ], and other materials are widely used to protect sensors from pollution. It is necessary to employ protective mechanisms to minimize these effects.…”

Recent progress and perspectives in applications of 2-methacryloyloxyethyl phosphorylcholine polymers in biodevices at small scales

“…[57][58][59][60][61][62][63] Several publications have reported the advantages of coating a standard electrode with MPC polymers, which can significantly increase binding selectivity and decrease noise during measurements because of their ability to prevent NPA. 51,52,54,55,64 For instance, Li et al synthesized poly(MPC-co-VPBA-co-vinylferrocene (VFC)) (referred to as PMVF in ref. 51) by radical polymerization.…”