CARBON NANOTUBE-GRAFT-POLY(CITRIC ACID) NANOCOMPOSITES

Abstract

Novel biodegradable nanocomposites containing multi wall carbon nanotubes (MWCNT) and poly(citric acid) (PCA) were successfully synthesized. For preparation of nanocomposites, MWCNT was opened using a mixture of sulfuric and nitric acid and its derivative containing – COOH and – OH functional groups was obtained. Polycondensation of monohydrate citric acid in the presence of functionalized MWCNT in the melting state was lead to nanotube-graft-poly(citric acid) (CNT-g-PCA) nanocomposites. The degree of polymerization of grafted hyperbranched poly(citric acid) onto the CNTs was controlled using CNT/citric acid ratio. The CNT-g-PCA were soluble in water freely and stirring their water solution and silver nitrate at room temperature lead to the CNT-g-PCA containing encapsulated silver nanoparticles in their polymeric shell. The structure of nanocomposites was characterized by TEM, DLS and spectroscopy methods.

Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube

“…MWNT-g-PCA was synthesized according to procedures reported in the literature. 26,27 Briefly, 1 g of MWNTs was mixed with 20 mL of concentrated HNO 3 and H 2 SO 4 (1:3 ratio), and the mixture was sonicated for 30 minutes and refluxed for 24 hours at 100°C. The resulting black mixture was then diluted with 1 L of distilled water, filtered, and washed with deionized water to adjust the pH to 6.…”

Modification of Carbon Nanotubes as an Effective Solution for Cancer Therapy

“…Several water-soluble polymers have been covalently and non-covalently attached onto the surface of CNTs to produce modified water-soluble CNT-polymer (Table 1). Depending on the type of conjugated polymer, modified CNTs can be soluble in aqueous or organic solvents, for example, conjugation of polylactide or polycaprolactone onto the surface of CNTs tends to solubilization of CNTs in organic solvents such as chloroform [102,103]. It has been proved that polymers not only raise the functionality, biocompatibility and water solubility of CNT but also are able to change the CNTs conformations dramatically [102][103][104].…”

“…Depending on the type of conjugated polymer, modified CNTs can be soluble in aqueous or organic solvents, for example, conjugation of polylactide or polycaprolactone onto the surface of CNTs tends to solubilization of CNTs in organic solvents such as chloroform [102,103]. It has been proved that polymers not only raise the functionality, biocompatibility and water solubility of CNT but also are able to change the CNTs conformations dramatically [102][103][104]. According to CNTs' polymeric and cationic innate abilities, soluble functionalized carbon nanotubes seem to represent an innovative drug delivery system, since they are capable to penetrate into the cell without altering their morphology [105,106].…”

Design and characterization of novel poly(vinyl chloride) nanocomposite films with zinc oxide immobilized with biocompatible citric acid

“…CA has been mainly used as an acidifier, flavoring, and for microbial fermentations for a long time. Besides, CA has been employed as chelating agent for removing heavy metals in soils due to its carboxylic groups [10][11][12]. NPs with high surface to volume ratio and numerous -OH functional groups on their surfaces have a great tendency to aggregate.…”