Carbon nanostructures as nerve scaffolds for repairing large gaps in severed nerves

Tavangarian, Fariborz; Li, Yiyao

doi:10.1016/j.ceramint.2012.05.038

Cited by 35 publications

(17 citation statements)

References 238 publications

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“…Their good mechanical properties also make them an interesting candidate for the creation of polymer composites utilized as bone replacements. Similarly, the excellent mechanical properties of diamond like carbon make it popular as a coating for various implants [100,101,102,103]. …”

Section: Nanoparticle Graftingmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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While polymers are widely utilized materials in the biomedical industry, they are rarely used in an unmodified state. Some kind of a surface treatment is often necessary to achieve properties suitable for specific applications. There are multiple methods of surface treatment, each with their own pros and cons, such as plasma and laser treatment, UV lamp modification, etching, grafting, metallization, ion sputtering and others. An appropriate treatment can change the physico-chemical properties of the surface of a polymer in a way that makes it attractive for a variety of biological compounds, or, on the contrary, makes the polymer exhibit antibacterial or cytotoxic properties, thus making the polymer usable in a variety of biomedical applications. This review examines four popular methods of polymer surface modification: laser treatment, ion implantation, plasma treatment and nanoparticle grafting. Surface treatment-induced changes of the physico-chemical properties, morphology, chemical composition and biocompatibility of a variety of polymer substrates are studied. Relevant biological methods are used to determine the influence of various surface treatments and grafting processes on the biocompatibility of the new surfaces—mammalian cell adhesion and proliferation is studied as well as other potential applications of the surface-treated polymer substrates in the biomedical industry.

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Section: Nanoparticle Graftingmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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“…The need for electrical stimulation makes carbon nanotubes (CNTs) and their derivatives an interesting option. For example, a fibrous combination of a biodegradable polymer with CNTs and graphene offer an alternative for the regeneration of the damaged central nervous system (CNS) [197][198][199][200], as does a combination with collagen [201].…”

Section: Soft Tissuesmentioning

confidence: 99%

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

Sachot¹,

Engel²,

Castaño

2014

COC

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Abstract:The introduction of hybrid materials in regenerative medicine has solved some problems related to the mechanical and bioactive properties of biomaterials. Calcium phosphates and their derivatives have provided the basis for inorganic components, thanks to their good bioactivity, especially in bone regeneration. When mixed with biodegradable polymers, the result is a synergic association that mimics the composition of many tissues of the human body and, additionally, exhibits suitable mechanical properties. Together with the development of nanotechnology and new synthesis methods, hybrids offer a promising option for the development of a third or fourth generation of smart biomaterials and scaffolds to guide the regeneration of natural tissues, with an optimum efficiency/cost ratio. Their potential bioactivity, as well as other valuable features of hybrids, open promising new pathways for their usein bone regeneration and other tissue repair therapies. This review provides a comprehensive overview of the different hybrid organic-inorganic scaffolding bio-materials developed so far for regenerative therapies, especially in bone. It also looks at the potential for research into hybrid materials for other, softer tissues, which is still at an initial stage, but with very promising results.

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“…[19] Currently, researchers are designing neural interfaces between the peripheral and central nervous system, and limb prostheses for patients with traumatic amputations and spinal cord injuries. [24,25] Figure 1: Histological staining of healed skin in each experimental group. Masson trichome staining shows the distribution and density of collagen protein in healed skin in various groups.…”

Section: Nerve Tubulizationmentioning

confidence: 99%