Carbon nanosheets to unravel the production of bioactive compounds from microalgae: A robust approach in drug discovery

Agarwal, Aakanksha; Selvam, Abhyavartin; Majood, Misba; Agrawal, Omnarayan; Chakrabarti, Sandip; Mukherjee, Monalisa

doi:10.1016/j.drudis.2023.103586

Cited by 5 publications

(1 citation statement)

References 101 publications

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“…Consequently, the strategy of hydrogel preparation modifies the innate characteristics of hydrogels, which thereby influences their clinical applicability in drug delivery, bioimaging, tissue engineering, cancer therapy, gene delivery, wound dressing/healing and so on. 3–22 Along these lines, physically engineered organo-hydrogels are developed by reversible physical interactions and their solubility can be tuned according to ambient conditions. 4 Contrastingly, chemically prepared gels are more stable in physiological environments due to covalent bonds formed by means of chemical reactions, such as Schiff base reactions, click chemistry, enzyme-mediation, Diels–Alder reactions, thiol exchange/disulfide crosslinking, and Michael-type addition.…”

Section: Introductionmentioning

confidence: 99%

Injectable organo-hydrogels influenced by click chemistry as a paramount stratagem in the conveyor belt of pharmaceutical revolution

Selvam,

Majood,

Chaurasia

et al. 2023

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Injectable organo-hydrogels influenced by click chemistry as a paramount stratagem in the conveyor belt of pharmaceutical revolution

Selvam,

Majood,

Chaurasia

et al. 2023

J. Mater. Chem. B

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Therapeutic Promises of Bioactive Rosavin: A Comprehensive Review with Mechanistic Insight

Aktar,

Bhuia,

Chowdhury

et al. 2024

Chemistry & Biodiversity

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Rosavin is an alkylbenzene diglycoside primarily found in Rhodiola rosea (L.), demonstrating various pharmacological properties in a number of preclinical test systems. This study focuses on evaluating the pharmacological effects of rosavin and the underlying molecular mechanisms based on different preclinical and non‐clinical investigations. The findings revealed that rosavin has anti‐microbial, antioxidant, and different protective effects, including neuroprotective effects against various neurodegenerative ailments such as mild cognitive disorders, neuropathic pain, depression, and stress, as well as gastroprotective, osteoprotective, pulmoprotective, and hepatoprotective activities. This protective effect of rosavin is due to its capability to diminish inflammation and oxidative stress. The compound also manifested anticancer properties against various cancer via exerting cytotoxicity, apoptotic cell death, arresting the different phases (G0/G1) of the cancerous cell cycle, inhibiting migration, and invading other organs. Rosavin also regulated MAPK/ERK signaling pathways to exert suppressing effect of cancer cell. However, because of its high‐water solubility, which lowers its permeability, the phytochemical has low oral bioavailability. The compound's relevant drug likeness was evaluated by the in silico ADME, revealing appropriate drug likeness. We suggest more extensive investigation and clinical studies to determine safety, efficacy, and human dose to establish the compound as a reliable therapeutic agent.

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Bioactive Compounds from Algae: Extraction, Purification, and Applications

Tyagi,

Sarma

2024

Value Added Products From Bioalgae Based Biorefineries: Opportunities and Challenges

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Carbon nanosheets to unravel the production of bioactive compounds from microalgae: A robust approach in drug discovery

Cited by 5 publications

References 101 publications

Injectable organo-hydrogels influenced by click chemistry as a paramount stratagem in the conveyor belt of pharmaceutical revolution

Injectable organo-hydrogels influenced by click chemistry as a paramount stratagem in the conveyor belt of pharmaceutical revolution

Therapeutic Promises of Bioactive Rosavin: A Comprehensive Review with Mechanistic Insight

Bioactive Compounds from Algae: Extraction, Purification, and Applications

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