Therapeutic Promises of Bioactive Rosavin: A Comprehensive Review with Mechanistic Insight

Abstract

Rosavin is an alkylbenzene diglycoside primarily found in Rhodiola rosea (L.), demonstrating various pharmacological properties in a number of preclinical test systems. This study focuses on evaluating the pharmacological effects of rosavin and the underlying molecular mechanisms based on different preclinical and non‐clinical investigations. The findings revealed that rosavin has anti‐microbial, antioxidant, and different protective effects, including neuroprotective effects against various neurodegenerative ailments such as mild cognitive disorders, neuropathic pain, depression, and stress, as well as gastroprotective, osteoprotective, pulmoprotective, and hepatoprotective activities. This protective effect of rosavin is due to its capability to diminish inflammation and oxidative stress. The compound also manifested anticancer properties against various cancer via exerting cytotoxicity, apoptotic cell death, arresting the different phases (G0/G1) of the cancerous cell cycle, inhibiting migration, and invading other organs. Rosavin also regulated MAPK/ERK signaling pathways to exert suppressing effect of cancer cell. However, because of its high‐water solubility, which lowers its permeability, the phytochemical has low oral bioavailability. The compound's relevant drug likeness was evaluated by the in silico ADME, revealing appropriate drug likeness. We suggest more extensive investigation and clinical studies to determine safety, efficacy, and human dose to establish the compound as a reliable therapeutic agent.

Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance

“…Rhodiola rosea Linn., commonly referred to as roseroot, has been approved by the Korean Food and Drug Administration as a supplement to improve stress-induced fatigue. Rosavin, a compound found in R. rosea , was reported to have potential therapeutic benefits for stress-related conditions and depression [ 14 ]. The study examined 3% rosavin and 1% salidroside combinations in animal models, showing anti-depressant, adaptogenic, and anxiolytic effects by reducing immobility and resting times while increasing active behaviors [ 15 ].…”