Carbon nanomaterials and amyloid-beta interactions: potentials for the detection and treatment of Alzheimer's disease?

Mohajeri, M. Hasan; Behnam, Behzad; Barreto, George E.; Sahebkar, Amirhossein

doi:10.1016/j.phrs.2019.03.023

Cited by 48 publications

(23 citation statements)

References 277 publications

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“…Carbon nanotubes (CNTs) have opened a novel perspective in medicine because of their characteristic features. Currently, they are extensively applied in gene delivery, cellular imaging, biosensor, cancer therapy and so on [189,190]. There have been efforts to use CS functionalized-CNTs for co-delivery of PTX and DOX in order to promote their anti-tumor activity [191].…”

Section: Chitosan As Co-delivery Systemmentioning

confidence: 99%

Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

Ashrafizadeh

Ahmadi

Mohamadi

et al. 2020

International Journal of Biological Macromolecules

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Paclitaxel (PTX) and docetaxel (DTX) are key members of taxenes with high anti-tumor activity against various cancer cells. These chemotherapeutic agents suffer from a number of drawbacks and it seems that low solubility in water is the most important one. Although much effort has been made in improving the bioavailability of PTX and DTX, the low bioavailability and minimal accumulation at tumor sites are still the challenges faced in PTX and DTX therapy.As a consequence, biomaterial-synthesized NPs have attracted much attention due to unique properties. Among them, chitosan (CS) is of interest due to its great biocompatibility. CS is a positively charged polysaccharide with the capability of interaction with negatively charged biomolecules. Besides, it can be processed into the sheet, micro/nano-particles, scaffold, and is dissolvable in mildly acidic pH similar to the pH of the tumor microenvironment. Keeping in mind the different applications of CS in the preparation of nanocarriers for delivery of PTX and DTX, in the present review, we demonstrate that how CS functionalized-nanocarriers and CS modification can be beneficial in enhancing the bioavailability of PTX and DTX, targeted delivery at tumor site, image-guided delivery and co-delivery with other anti-tumor drugs or genes.

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Section: Chitosan As Co-delivery Systemmentioning

confidence: 99%

Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

Ashrafizadeh

Ahmadi

Mohamadi

et al. 2020

International Journal of Biological Macromolecules

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“…[129] Carbon-based nanoparticles have been widely used in various biomedical applications such as biosensing, imaging, and drug delivery. [130,131] C 60 disrupted Aβ fibrillization by destructing the β-helical twist, destabilizing the D23-K28 salt bridge and hydrophobic interactions between the Aβ peptides. [132] 1,2-(dimethoxymethano) fullerene, a water-soluble fullerene derivative, inhibited the dimerization of Aβ by binding with the peptide aromatic residues (F4 and Y10), the central hydrophobic region (L17-A21) and the C-terminal hydrophobic regions (I31-V40).…”

Section: Simulation Studiesmentioning

confidence: 99%

The Membrane Axis of Alzheimer's Nanomedicine

Tang

Andrikopoulos

et al. 2020

Advanced NanoBiomed Research

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Alzheimer's disease (AD) is a major neurological disorder impairing its carrier's cognitive function, memory, and lifespan. While the development of AD nanomedicine is still nascent, the field is evolving into a new scientific frontier driven by the diverse physicochemical properties and theranostic potential of nanomaterials and nanocomposites. Characteristic to the AD pathology is the deposition of amyloid plaques and tangles of amyloid beta (Aβ) and tau, whose aggregation kinetics may be curbed by nanoparticle inhibitors via sequence‐specific targeting or nonspecific interactions with the amyloidogenic proteins. As literature implicates cell membrane as a culprit in AD pathogenesis, herein, the membrane axis of AD nanomedicine is summarized and a new rationale that the field development may greatly benefit from harnessing our existing knowledge of Aβ‐membrane interaction, nanoparticle–membrane interaction, and Aβ–nanoparticle interaction is presented.

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“…A catálise do processo pode ocorrer aumentando a concentração local de proteínas e acelerando a taxa de nucleação na superfície da nanopartícula (NP), enquanto uma ligação estreita ou uma grande área de superfície das partículas com os peptídeos pode levar à inibição da agregação. Apesar dessas observações, os processos detalhados subjacentes à associação de nanomateriais e Aβ até o presente momento não está totalmente elucidado (Hu et al, 2016(Hu et al, , 2017Mankar et al, 2011;Mohajeri et al, 2019).…”

Section: Introductionunclassified

Abordagens de modelagem para investigar a interação entre Fulereno e β-Amiloide

Cruz

Cruz²,

Alves

et al. 2021

RSD

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A doença de Alzheimer é a perda progressiva da função mental, caracterizada pela degeneração do tecido do cérebro, incluindo a perda de células nervosas, a acumulação de uma proteína anormal chamada β-amiloide e o desenvolvimento de tranças neuro fibrilares. A agregação de β-amiloide é uma característica fisiológica da doença de Alzheimer e está intimamente relacionada a neurodegeneração causada pelo Alzheimer. Recentemente novas terapias buscam compostos promissores capazes de desagregar a β-amiloide. Nanopartículas (NPs) são candidatos altamente promissores para várias aplicações biológicas importantes, como entrega de genes, imagens celulares e terapia de tumores. Entre numerosos tipos de nanomateriais, as NPs de carbono têm atraído interesses particulares, como: fulereno de dimensão zero, nanotubos de carbono unidimensionais (1D) e grafeno bidimensional (2D). Devido a isso, utilizamos molecular docking para investigar a capacidade de interação da nanopartícula de fulereno com o agregado β-amiloide. Os resultados de docking demonstraram que as principais interações estabelecidas foram hidrofóbicas. O Sistema teve energia de afinidade de -41.04 Kcal, obtido com o método MM-GBSA.

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Carbon nanomaterials and amyloid-beta interactions: potentials for the detection and treatment of Alzheimer's disease?

Cited by 48 publications

References 277 publications

Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

The Membrane Axis of Alzheimer's Nanomedicine

Abordagens de modelagem para investigar a interação entre Fulereno e β-Amiloide

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