Carbon nanomaterial-enhanced scaffolds for the creation of cardiac tissue constructs: A new frontier in cardiac tissue engineering

Dozois, Matthew D.; Bahlmann, Laura C.; Zilberman, Yoram; Tang, Xiaowu Shirley

doi:10.1016/j.carbon.2017.05.050

Cited by 56 publications

(50 citation statements)

References 55 publications

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“…The treatment of myocardial damage represents a significant health problem due to the increased number of population suffering from cardiovascular diseases (CVDs) [155]. Common treatments involve surgical approaches, the use of left ventricular assistance devices (LVAD), pharmacological and gene therapies [156].…”

Section: Cardiac Tissue Engineeringmentioning

confidence: 99%

“…Common treatments involve surgical approaches, the use of left ventricular assistance devices (LVAD), pharmacological and gene therapies [156]. However, these treatments present several limitations such as the lack of donated organs, thrombosis, infection, bleeding, and low clinical efficiency [155,[157][158][159]. Gene therapy is a relatively recent treatment, based on the use of a vial virus carrying genes to the targeted cells.…”

Section: Cardiac Tissue Engineeringmentioning

confidence: 99%

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Carbon nanotubes and their polymeric composites: the applications in tissue engineering

Huang

2020

Biomanuf Rev

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Carbon nanotubes (CNTs), with unique graphitic structure, superior mechanical, electrical, optical and biological properties, has attracted more and more interests in biomedical applications, including gene/drug delivery, bioimaging, biosensor and tissue engineering. In this review, we focus on the role of CNTs and their polymeric composites in tissue engineering applications, with emphasis on their usages in the nerve, cardiac and bone tissue regenerations. The intrinsic natures of CNTs including their physical and chemical properties are first introduced, explaining the structure effects on CNTs electrical conductivity and various functionalization of CNTs to improve their hydrophobic characteristics. Biosafety issues of CNTs are also discussed in detail including the potential reasons to induce the toxicity and their potential strategies to minimise the toxicity effects. Several processing strategies including solution-based processing, polymerization, melt-based processing and grafting methods are presented to show the 2D/3D construct formations using the polymeric composite containing CNTs. For the sake of improving mechanical, electrical and biological properties and minimising the potential toxicity effects, recent advances using polymer/CNT composite the tissue engineering applications are displayed and they are mainly used in the neural tissue (to improve electrical conductivity and biological properties), cardiac tissue (to improve electrical, elastic properties and biological properties) and bone tissue (to improve mechanical properties and biological properties). Current limitations of CNTs in the tissue engineering are discussed and the corresponded future prospective are also provided. Overall, this review indicates that CNTs are promising “next-generation” materials for future biomedical applications.

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Section: Cardiac Tissue Engineeringmentioning

confidence: 99%

Section: Cardiac Tissue Engineeringmentioning

confidence: 99%

Carbon nanotubes and their polymeric composites: the applications in tissue engineering

Huang

2020

Biomanuf Rev

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“…[4] NDs synthesized by detonation and photothermal agents [23,24] as well as for biosensing [25] and tissue regeneration (Figure 2). [26] In addition, the intrinsic optical and electronic properties of carbon nanomaterials make them useful for a variety of imaging modalities such as magnetic resonance imaging, near-infrared fluorescence, photoacoustic tomography, as well as photothermal and Raman imaging. [27][28][29][30][31] The impact of carbon nanomaterials on immune cells is critical in terms of clinical translation.…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

Soltani

Guo

Bianco

et al. 2020

Advanced Therapeutics

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In the last decade, graphene‐based nanomaterials and carbon dots have joined the family of carbon materials mainly composed of graphite, diamond, fullerene, and carbon nanotubes. Carbon nanomaterials have been widely exploited in various fields from electronics and materials science to nanomedicine. The studies on their effect on the immune system have revealed that they possess intrinsic anti‐inflammatory properties, reducing the production of proinflammatory cytokines and modulating immune cell maturation. In addition, their large specific surface area associated with high biocompatibility allows their use as carriers for the delivery of anti‐inflammatory agents. They can also contribute to the diagnosis of inflammatory diseases as biosensors for low‐limit detection and quantification of inflammation‐related biomarkers in body fluids and tissues allowing to monitor the concentration of drugs in urine and guide personalized drug usage. Finally, they are used as adsorbents for blood plasma purification in the clinical treatment of sepsis through efficient removal of certain cytokines. This review focuses on the intrinsic anti‐inflammatory properties of carbon nanomaterials. An overview is provided on their use as carriers of anti‐inflammatory drugs, as biosensors, and for blood purification in the context of inflammatory diseases. The potential of carbon nanomaterials for clinical translation is also critically discussed.

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“…Carbon nanomaterials with different scales such as one-dimensional (1D) CNTs, 1D CNFs, and twodimensional (2D) graphene sheets have been introduced as cardiac patches or scaffolds, particularly in polymer composite forms. [18][19][20][21] For example, carbon nanotube/collagen-based substrates significantly promoted the adhesion, spreading, growth, and improved cardiogenesis of adipose-derived stem cells. 22 In another study, a bioactuator was fabricated as a cell stimulator; it contained an aligned CNT microelectrode integrated into a hydrogel-culturing cardiomyocytes on the bioactuator-produced cardiac tissue with homogeneous cell organization, cell-to-cell coupling, and spontaneous actuation behavior.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional graphene foam as a conductive scaffold for cardiac tissue engineering

et al. 2019

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Myocardial infarction is one of the major causes of mortality throughout the world. Cardiac scaffolds are tissueengineered structures for the treatment of myocardial infarction and are employed for tissue support and cell delivery to the injured region. In this study, we fabricated nanostructured graphene foams as porous and biocompatible cardiac tissue-engineering scaffolds. Three-dimensional graphene foam and two-dimensional graphene were fabricated using chemical vapor deposition. We showed that the nickel etching had no effect on the structural appearance of the threedimensional graphene foam. Toxicity of the prepared samples was evaluated on human umbilical vein endothelial cells at 48 h and 72 h and showed no toxic effects on the viability of the cells. Moreover, both samples supported the adhesion and growth of neonatal cardiomyocytes with three-dimensional graphene foam showing a more extensive effect on the expression of the cardiac genes involved in muscle contraction and relaxation (troponin-T) and gap junctions (Connexin 43). Hence, conductive three-dimensional graphene foam with its large surface area and specific surface properties could provide a promising platform for cardiac tissue engineering.

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Carbon nanomaterial-enhanced scaffolds for the creation of cardiac tissue constructs: A new frontier in cardiac tissue engineering

Cited by 56 publications

References 55 publications

Carbon nanotubes and their polymeric composites: the applications in tissue engineering

Carbon nanotubes and their polymeric composites: the applications in tissue engineering

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

Three-dimensional graphene foam as a conductive scaffold for cardiac tissue engineering

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