Carbon dots for cancer nanomedicine: a bright future

Bayda, Samer; Amadio, Emanuele; Cailotto, Simone; Frión-Herrera, Yahima; Perosa, Alvise; Rizzolio, Flavio

doi:10.1039/d1na00036e

Cited by 42 publications

(28 citation statements)

References 347 publications

(564 reference statements)

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“…HR-TEM images of TCDs (Figure 1) reveal a graphitic-based material with a lattice spacing of 0.24 ± 0.03 nm, which fits with the expected value for graphite (0.21 nm) [20]. The size distribution is inhomogeneous, with a mean value of 9 ± 3 nm.…”

Section: Structural and Morphological Characterizationsupporting

confidence: 67%

Biocompatibility and Antioxidant Capabilities of Carbon Dots Obtained from Tomato (Solanum lycopersicum)

et al. 2022

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Since their discovery in 2004, carbon dots have attracted strong interest in the scientific community due to their characteristic properties, particularly their luminescence and their ease of synthesis and derivatization. Carbon dots can be obtained from different carbon sources, including natural products, resulting in a so-called ’green synthesis’. In this work, we obtain carbon dots from tomato juice in order to obtain nanoparticles with the antioxidant capabilities of the natural antioxidants present in that fruit. The obtained material is characterized regarding nanoparticle size distribution, morphology, surface functional groups and optic properties. Antioxidant properties are also evaluated through the DPPH method and their cytotoxicity is checked against human dermal fibroblast and A549 cell-lines. The results indicate that carbon dots obtained from tomato have a higher antioxidant power than other already-published antioxidant carbon dots. The bandgap of the synthesized materials was also estimated and coherent with the literature values. Moreover, carbon dots obtained from tomato juice are barely toxic for healthy cells up to 72 h, while they induce a certain cytotoxicity in A549 lung carcinoma cells.

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Section: Structural and Morphological Characterizationsupporting

confidence: 67%

Biocompatibility and Antioxidant Capabilities of Carbon Dots Obtained from Tomato (Solanum lycopersicum)

et al. 2022

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“…For instance, carbon nanomaterials are usually hard to degrade in vivo and have the risk of increased side effects [121,122]. Polymeric nanoparticles possess good biocompatibility and manufacturing advantages, but they have limited tumor targeting ability without additional ligand modifications [117,123].…”

Section: Advantages Of Protein Nanoparticles For Cancer Nanomedicinementioning

confidence: 99%

“…Inorganic nanoparticles can be easily synthesized and modified, but they may release excess toxic ions when used for cancer treatment [ 119 , 120 ]. For instance, carbon nanomaterials are usually hard to degrade in vivo and have the risk of increased side effects [ 121 , 122 ]. Polymeric nanoparticles possess good biocompatibility and manufacturing advantages, but they have limited tumor targeting ability without additional ligand modifications [ 117 , 123 ].…”

Section: Design Of Protein Nanoparticlesmentioning

confidence: 99%

Protein nanoparticles directed cancer imaging and therapy

Miao

Yang

et al. 2022

Nano Convergence

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Cancer has been a serious threat to human health. Among drug delivery carriers, protein nanoparticles are unique because of their mild and environmentally friendly preparation methods. They also inherit desired characteristics from natural proteins, such as biocompatibility and biodegradability. Therefore, they have solved some problems inherent to inorganic nanocarriers such as poor biocompatibility. Also, the surface groups and cavity of protein nanoparticles allow for easy surface modification and drug loading. Besides, protein nanoparticles can be combined with inorganic nanoparticles or contrast agents to form multifunctional theranostic platforms. This review introduces representative protein nanoparticles applicable in cancer theranostics, including virus-like particles, albumin nanoparticles, silk protein nanoparticles, and ferritin nanoparticles. It also describes the common methods for preparing them. It then critically analyzes the use of a variety of protein nanoparticles in improved cancer imaging and therapy.

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“…Similarly, nanotechnology has played a vital role in the treatment and diagnosis of cancer in the past years. Specifically, over the years carbon quantum dot (CQD)-based strategy provides a wide range of applications such as fluorescence imaging(C. Shi et al, 2019 ), drug delivery ( Su et al, 2020 ), photoinduced therapy ( Zhang et al, 2017 ), and nanomedicine ( Bayda et al, 2021 ). CQDsare given attention in biomedical applications due to their promising properties such as tunable fluorescence ( Wang C. et al, 2020 ) , biocompatibility ( Teradal and Jelinek 2017 ), low toxicity, good electrical and chemical stability ( Tian et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A Strategic Review on Carbon Quantum Dots for Cancer-Diagnostics and Treatment

Naik

Chaudhary

et al. 2022

Front. Bioeng. Biotechnol.

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The understanding of the genesis of life-threatening cancer and its invasion calls for urgent development of novel technologies for real-time observations, early diagnosis, and treatment. Quantum dots (QDs) grabbed the spotlight in oncology owing to their excellent photostability, bright fluorescence, high biocompatibility, good electrical and chemical stability with minimum invasiveness. Recently, carbon QDs (CQDs) have become popular over toxic inorganic QDs in the area of bioimaging, biosensing, and drug delivery. Further, CQDs derived from natural sources like biomolecules and medicinal plants have drawn attention because of their one-pot, low-cost and ease of synthesis, along with remarkable tunable optical properties and biocompatibility. This review introduces the synthesis and properties of CQDs derived from natural sources, focusing on the applicability of CQD-based technologies as nano-theranostics for the diagnosis and treatment of cancer. Furthermore, the current issues and future directions for the transformation of CQDs-based nanotechnologies to clinical applications are highlighted.

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Carbon dots for cancer nanomedicine: a bright future

Abstract: Cancer remains one of the main causes of death in the world. Early diagnosis and effective cancer therapies are required to treat this pathology. Traditional therapeutic approaches are limited by...

Cited by 42 publications

References 347 publications

Biocompatibility and Antioxidant Capabilities of Carbon Dots Obtained from Tomato (Solanum lycopersicum)

Biocompatibility and Antioxidant Capabilities of Carbon Dots Obtained from Tomato (Solanum lycopersicum)

Protein nanoparticles directed cancer imaging and therapy

A Strategic Review on Carbon Quantum Dots for Cancer-Diagnostics and Treatment

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