Biocompatibility and Antioxidant Capabilities of Carbon Dots Obtained from Tomato (Solanum lycopersicum)

Rodríguez-Varillas, Sandra; Fontanil, Tania; Obaya, Álvaro J.; Fernández‐González, Alfonso; Murru, Clarissa; Badía‐Laiño, Rosana

doi:10.3390/app12020773

Cited by 22 publications

(18 citation statements)

References 27 publications

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“…The band gap of gCDs was found to be 3.34 and 3.30 eV for RCDs and APCDs, respectively. These values are consistent with those in works already published [ 33 , 34 , 35 , 36 ]. The meaning of these data concerning the reactivity of the gCDs [ 37 ] in the context of the present paper has been discussed in detail in the Supplementary Information .…”

Section: Resultssupporting

confidence: 93%

Green Carbon Dots as Additives of Biopolymer Films for Preserving from Oxidation of Oil-Based Products

et al. 2022

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The deterioration of oil-based products during processing, distribution and storage has a major negative impact on the industry from an economic point of view. The spoilage of oil is mainly due to its oxidation which can be triggered by various factors, such as UV light, heating or the presence of impurities that result in the formation of radical species. In this context, several packaging alternatives have recently been developed with the aim to protect and extend the shelf life of oil-based products. This work aimed to study the antioxidant properties of bio-polymer-based films (BPFs) obtained from high methoxylated pectin (HMP) and sodium caseinate (CAS) and enriched with different concentrations of green carbon dots (gCDs), 0.25%, 0.50 and 1% w/w, obtained from apple pomace (APCDs) and rosemary powder (RCDs). The resulting films (gCDs-BPFs) have shown that the presence of gCDs not only modified the surface roughness of the films, but also positively affected their antioxidant properties. The addition of gCDs enhanced the radical inhibiting capacity of the raw BPFs by 42 and 62% for the films containing 1% RCDs and 1% APCDs, respectively. As a proof of the concept, two oil samples (edible and cosmetic) were treated with the obtained antioxidant films, and the results demonstrated that in both types of samples the oxidation process was minimized during the five days of the experiment. These results are promising and suggest that the antioxidant bio-polymer-based films could be excellent candidates for further production of active packaging.

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Section: Resultssupporting

confidence: 93%

Green Carbon Dots as Additives of Biopolymer Films for Preserving from Oxidation of Oil-Based Products

et al. 2022

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“…This phenomenon results in free radicals on the NP surface, which could be stabilized by the rearrangement of functional groups among themselves or through resonance of unpaired electrons. 57 Here, our results clearly suggest that there are reasonable antioxidant properties of the CWR-derived NDs and could have wide implications in future biological and therapeutic applications of NDs. Furthermore, specific detailed in vitro and in vivo studies are necessary for better understanding of the antioxidant effects and its correlation with antiviral and other biological activities.…”

Section: Resultssupporting

confidence: 56%

Biocompatible Nanodiamonds Derived from Coal Washery Rejects: Antioxidant, Antiviral, and Phytotoxic Applications

et al. 2023

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Coal washery rejects (CWRs) are a major byproduct produced in coal washery industries. We have chemically derived biocompatible nanodiamonds (NDs) from CWRs toward a wide range of biological applications. The average particle sizes of the derived blueemitting NDs are found to be in the range of 2−3.5 nm. High-resolution transmission electron microscopy of the derived NDs depicts the crystalline structure with a d-spacing of 0.218 nm, which is attributed to the 100 lattice plane of a cubic diamond. The Fourier infrared spectroscopy, zeta potential, and X-ray photoelectron spectroscopy (XPS) data revealed that the NDs are substantially functionalized with oxygencontaining functional groups. Interestingly, the CWR-derived NDs exhibit strong antiviral properties (high inhibition of 99.3% with an IC 50 value of 7.664 μg/mL) and moderate antioxidant activity that widen the possibility of biomedical applications. In addition, toxicological effects of NDs on the wheatgrass seed germination and seedling growth showed minimal inhibition (<9%) at the highest tested concentration of 300.0 μg/mL. The study also provides intriguing prospects of CWRs for the creation of novel antiviral therapies.

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“…Similarly, carotenoids are derived from fruits and vegetables (e.g., potatoes and carrots) and are considered phytochemical antioxidants [ 17 ]. Carbon-based materials exhibit significant hydroxyl radical scavenging activity and can also be produced from physical sources [ 44 , 45 ]. Melanin’s antioxidant and photoprotective properties have been studied in this context [ 46 , 47 ].…”

Section: Natural and Artificial Biomimetic Antioxidantsmentioning

confidence: 99%

“…A compound’s antioxidant capacity can generally be expressed as radical scavenging capacity (% RSC). The % RSC can be estimated by Equation (1) [ 45 ].

where A 0 is the initial absorption, while A 1 is the absorption after the reaction.…”

Section: Evaluation Of the Antioxidant Activitymentioning

confidence: 99%

Nanoantioxidant Materials: Nanoengineering Inspired by Nature

et al. 2023

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Oxidants are very active compounds that can cause damage to biological systems under specific environmental conditions. One effective way to counterbalance these adverse effects is the use of anti-oxidants. At low concentrations, an antioxidant is defined as a compound that can delay, control, or prevent an oxidative process. Antioxidants exist in plants, soil, and minerals; therefore, nature is a rich source of natural antioxidants, such as tocopherols and polyphenols. In nature, antioxidants perform in tandem with their bio-environment, which may tune their activity and protect them from degradation. In vitro use of antioxidants, i.e., out of their biomatrix, may encounter several drawbacks, such as auto-oxidation and polymerization. Artificial nanoantioxidants can be developed via surface modification of a nanoparticle with an antioxidant that can be either natural or synthetic, directly mimicking a natural antioxidant system. In this direction, state-of-the-art nanotechnology has been extensively incorporated to overcome inherent drawbacks encountered in vitro use of antioxidants, i.e., out of their biomatrix, and facilitate the production and use of antioxidants on a larger scale. Biomimetic nanoengineering has been adopted to optimize bio-medical antioxidant systems to improve stability, control release, enhance targeted administration, and overcome toxicity and biocompatibility issues. Focusing on biotechnological sciences, this review highlights the importance of nanoengineering in developing effective antioxidant structures and comparing the effectiveness of different nanoengineering methods. Additionally, this study gathers and clarifies the different antioxidant mechanisms reported in the literature and provides a clear picture of the existing evaluation methods, which can provide vital insights into bio-medical applications.

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Biocompatibility and Antioxidant Capabilities of Carbon Dots Obtained from Tomato (Solanum lycopersicum)

Cited by 22 publications

References 27 publications

Green Carbon Dots as Additives of Biopolymer Films for Preserving from Oxidation of Oil-Based Products

Green Carbon Dots as Additives of Biopolymer Films for Preserving from Oxidation of Oil-Based Products

Biocompatible Nanodiamonds Derived from Coal Washery Rejects: Antioxidant, Antiviral, and Phytotoxic Applications

Nanoantioxidant Materials: Nanoengineering Inspired by Nature

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