Carbon Dots for Bioimaging and Biosensing Applications

Kang, Zhenhui; Liu, Yang; Lee, Shuit‐Tong

doi:10.1007/5346_2017_10

Cited by 5 publications

(4 citation statements)

References 135 publications

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“…Contrary to this, CDs have similar remarkable fluorescent properties but extremely low cytotoxicity, which makes them strong candidates to be used to design novel bioimaging probes. 149,150 Fluorescence Imaging. Teng et al selected the blue luminescent N-CDs to incubate with a human cervical cancer cell line for 2 h under different channels, clearly visualized the fluorescent imaging of HeLa cells.…”

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

“…Traditional semiconductor QDs and noble metal clusters containing heavy metal have been substantially investigated in bioimaging both in vitro and in vivo due to their excellent fluorescent properties, but consequential health hazardous concern associated with the heavy metal has impeded their applicability in bioimaging. Contrary to this, CDs have similar remarkable fluorescent properties but extremely low cytotoxicity, which makes them strong candidates to be used to design novel bioimaging probes. , …”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Recent Advances in Synthesis, Optical Properties, and Biomedical Applications of Carbon Dots

Sadat

Ding

et al. 2019

ACS Appl. Bio Mater.

251

156

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Carbon dots (CDs) are relatively new and one of the most propitious nanomaterials ever known to humanity, primarily consisting of a carbonized carbon core with heteroatoms in organic functional groups attached. CDs show various fascinating properties, such as tunable excitation/emission, chemical inertness, photostability, low toxicity, good biocompatibility, ease of handling, and eco-friendliness. Due to the anomalous optical and chemical properties of the CDs, they have a wide range of applications in the fields of bioimaging, biosensing, photocatalysis, optoelectronics, etc. In this Review, we intend to cover the many strides in CDs chemistry, which is an emerging paradigm, in conjunction with the most recent discoveries of CDs with near-infrared fluorescence, phosphorescence, electroluminescence, chirality, and antibacterial activity. Our main emphasis will be on the contemporary evolution in synthetic strategies, optical properties, and biomedical applications of CDs in nanomedicine and nanotheranostics.

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Section: Acs Applied Bio Materialsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Recent Advances in Synthesis, Optical Properties, and Biomedical Applications of Carbon Dots

Sadat

Ding

et al. 2019

ACS Appl. Bio Mater.

251

156

View full text Add to dashboard Cite

show abstract

“…The toxicity, blood compatibility, rapid excretion from the body, suitable hydrodynamic diameter, and the lowest possible adsorption of proteins must be taken into account [43]. Another parameter which must be carefully considered is the excitation/emission wavelength, because the light can be scattered due to the Rayleigh scattering effect in the tissue and results in a high background signal [95]. The first study to present the feasibility of CNDs for in vivo imaging was published in 2009 by Yang et al [96].…”

Section: In Vivo Imaging Applicationsmentioning

confidence: 99%

Bioimaging Applications of Carbon Nanodots: A Review

Kasouni

Chatzimitakos

Stalikas

2019

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Carbon nanodots (CNDs) is the newest member of carbon-based nanomaterials and one of the most promising for the development of new, advanced applications. Owing to their unique and unparalleled physicochemical and photoluminescent properties, they are considered to be a rising star among nanomaterials. During the last decade, many applications have been developed based on CNDs. Among others, they have been used as bioimaging agents to label cells and tissues. In this review, we will discuss the advancements in the applications of CNDs in in the field of imaging, in all types of organisms (i.e., prokaryotes, eukaryotes, and animals). Selective imaging of one type of cells over another, imaging of (bio)molecules inside cells and tumor-targeting imaging are some of the studies that will be discussed hereafter. We hope that this review will assist researchers with obtaining a holistic view of the developed applications and hit on new ideas so that more advanced applications can be developed in the near future.

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“…Carbon quantum dots can be obtained through a variety of methods ( Table 1 ). Size control is critical in the synthesis of carbon quantum dots [ 20 ] and, collectively, it can be seen from Table 1 that poor size control is the main problem in the synthesis of carbon quantum dots. Accordingly, synthesis of carbon quantum dots is often followed by dialysis [ 21 ], centrifugation [ 22 ] or filtration [ 23 ] to obtain a uniform size distribution.…”

Section: Introductionmentioning

confidence: 99%

Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications

Liu

Mei

et al. 2021

Antibiotics

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Nanoparticles possess unique features due to their small size and can be composed of different surface chemistries. Carbon quantum dots possess several unique physico-chemical and antibacterial activities. This review provides an overview of different methods to prepare carbon quantum dots from different carbon sources in order to provide guidelines for choosing methods and carbon sources that yield carbon quantum dots with optimal antibacterial efficacy. Antibacterial activities of carbon quantum dots predominantly involve cell wall damage and disruption of the matrix of infectious biofilms through reactive oxygen species (ROS) generation to cause dispersal of infecting pathogens that enhance their susceptibility to antibiotics. Quaternized carbon quantum dots from organic carbon sources have been found to be equally efficacious for controlling wound infection and pneumonia in rodents as antibiotics. Carbon quantum dots derived through heating of natural carbon sources can inherit properties that resemble those of the carbon sources they are derived from. This makes antibiotics, medicinal herbs and plants or probiotic bacteria ideal sources for the synthesis of antibacterial carbon quantum dots. Importantly, carbon quantum dots have been suggested to yield a lower chance of inducing bacterial resistance than antibiotics, making carbon quantum dots attractive for large scale clinical use.

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Carbon Dots for Bioimaging and Biosensing Applications

Cited by 5 publications

References 135 publications

Recent Advances in Synthesis, Optical Properties, and Biomedical Applications of Carbon Dots

Recent Advances in Synthesis, Optical Properties, and Biomedical Applications of Carbon Dots

Bioimaging Applications of Carbon Nanodots: A Review

Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications

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