Carbon dots: emerging theranostic nanoarchitectures

Mishra, Vijay; Patil, Abhinandan; Thakur, Sourav; Kesharwani, Prashant

doi:10.1016/j.drudis.2018.01.006

Cited by 165 publications

(107 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Modern medical research [8] has also confirmed that STC is an effective haemostatic after carbonisation. Carbon dots are nanoparticles, usually 1-10 nm in diameter, with proven theranostic activity [9]. In recent years, under the existing concepts of the material basis for traditional Chinese medicine, many scholars [6,10] have attempted to gain an understanding of the haemostatic material foundation of small molecules or metal ions from the perspective of Chinese medicine, but no obvious research progress has been made.…”

Section: Introductionmentioning

confidence: 99%

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

et al. 2020

View full text Add to dashboard Cite

High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisata (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet–visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4–2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy.

show abstract

Section: Introductionmentioning

confidence: 99%

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

et al. 2020

View full text Add to dashboard Cite

show abstract

“…C‐dots generally show the high stability, biocompatibility, and simplicity of synthesis. The C‐dots can be derived from a variety of resources and different types of doping are used to enhance specific properties of C‐dots . Recent studies showed that food‐derived C‐dots exhibit inhibition against cancer cell growth.…”

Section: Introductionmentioning

confidence: 99%

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

et al. 2019

View full text Add to dashboard Cite

Carbon nanodots (C‐dots) are emerging as a new type of promising agent in anticancer, imaging, and new energy. Reports as well as the previous research indicate that certain C‐dots can enhance targeted cancer therapy. However, in‐depth mechanisms for such anticancer effect remain unclear. In this work, treatment provided by the date pit‐derived C‐dots, exhibits significant DNA damage; Annexin V/7‐AAD‐mediated apoptosis, and G2/M cell cycle arrest in prostate cancer cells. The application of C‐dots to the cell generally leads to acidulation of the cell medium, cooperated with membrane compact. The date pit‐derived C‐dots are observed inhibiting the horseradish peroxidase. Moreover, the C‐dots disrupt likely through nucleotide excision DNA repair at low dose during DNA ligation step suggesting the antimicrobial effect and targeting Pim‐1, EGFR, mTOR, and DNA damage pathways in cancer cells. For the first time the detailed and novel mechanisms underlying the C‐dots, derived from the date‐pit, as an efficient, low‐cost, and green nanomaterial are reveled for cancer therapy and anti‐infection.

show abstract

“…Carbon dots (CDs) is a relatively new carbon nanomaterial that has been extensively studied the last decade, due to its unique characteristics and properties. Strong photoluminescence, easy and low-cost preparative methods, stability, biocompatibility, and low toxicity are the main characteristics and properties of CDs that have attracted a huge interest for their use in various potential applications, especially in bio sensing and imaging, as well as in light emitting devices, fluorescence probes, environmental engineering, and photocatalysis [1][2][3][4][5][6][7]. Among a plethora of different procedures that have been presented up to now, microwave or thermal pyrolysis, electrochemical oxidation, hydrothermal treatments, and laser ablation are the most common approaches to create CDs.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Carbon Dots Ink for Gravure Printing

Koutsioukis

Belessi

Georgakilas

2019

View full text Add to dashboard Cite

In the present article, we describe the use of highly fluorescent carbon dots (CDs) for the preparation of an effective water-based carbon dot ink (CD-ink) for gravure printing. Carbon dots were prepared hydrothermally from citrate and triethylenetetramine, and mixed properly with certain resins that are used in gravure inks. The as-produced CD gravure ink was used successfully for printing high quality fluorescent images.

show abstract

Carbon dots: emerging theranostic nanoarchitectures

Cited by 165 publications

References 87 publications

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

Fluorescent Carbon Dots Ink for Gravure Printing

Contact Info

Product

Resources

About