Carbon dots based photoelectrochemical sensors for ultrasensitive detection of glutathione and its applications in probing of myocardial infarction

Li, Zhengping; Zhang, Jun; Li, Yunxiao; Zhao, Shuang; Zhang, Peixin; Zhang, Yue; Bi, Jinshun; Liu, Guohua; Yue, Zhao

doi:10.1016/j.bios.2017.07.065

Cited by 101 publications

(30 citation statements)

References 44 publications

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“…12,[61][62][63][64][65] Carbon dots are now a major nano-component of sensitive sensors and signal amplifiers for extremely low quantities of specific physiological metabolites and biomolecules, mineral ions, herbs, vitamins, drugs, volatile organic compounds, and other agents. [66][67][68][69] As a proof of principle, it is even possible to process food waste water sources per se to synthesize photo-luminescent carbon nano-dots from their organic source material. 70,71 Thus, homeopathic medicines containing carbon dots might literally serve as very crude sensor-carriers for the medicine source material and its constituent information at profoundly low femtomolar 72 or picogram concentrations.…”

Section: Homeopathic Medicines As Complex Systemsmentioning

confidence: 99%

The Complexity of the Homeopathic Healing Response Part 2: The Role of the Homeopathic Simillimum as a Complex System in Initiating Recovery from Disease

Bell

2019

Homeopathy

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Background Evidence indicates that homeopathic medicines are complex self-organizing nano-scale systems that generate unique low-intensity electromagnetic signals and/or quantum coherence domains. In Part 1, we reviewed relevant concepts from complex adaptive systems science on living systems for the nature of homeopathic healing. Aim In Part 2, we discuss the complex-system nature of homeopathic medicines. The aim is to relate the evidence on the nature and properties of homeopathic medicines to the complex systems model for homeopathic healing. Methods and Results The work is a narrative review, with complexity model development for the nature of homeopathic medicines. Studies suggest that homeopathic manufacturing generates nano-structures of source material, silica and silicon quantum dots if succussed in glassware or including botanical source materials; or carbon quantum dots if succussed in plastic or including any organic source materials, as well as solute-induced water nano-structures carrying medicine-specific information. On contact with physiological fluids (e.g., blood plasma), there is evidence that nano-structures additionally adsorb individualized patterns of the recipient's own proteins on to their surfaces to create a unique protein corona coat (shell). Thus, the simillimum may generate a personalized biological identity upon administration. Consequently, a medicine can serve as an individually salient, self-similar information carrier, whose protein corona constituent pattern reflects the individual's current internal state of health/disease. Homeopathic medicine complexity emerges from interactions of the component parts from source, silica from glassware or carbon from plastic containers, solvents (lactose, water, ethanol), adsorbed biomolecule layers from plant or animal sources, and adsorbed biomolecules of the recipient. Low doses of these complex medicines can act as biological signaling agents to initiate hormesis via a network-wide pattern of adaptive responses by the recipient complex adaptive system, rather than as conventional pharmaceutical drugs. Biological mediators of adaptive responses include inter-connected network elements of the cell danger/damage defense system: for example, gene expression, reactive oxygen species, heat shock proteins, cytokines, macrophages, T-cells, and associated brain–immune system mediator pathways. Conclusions Every homeopathic medicine is a complex nano-scale system involving multiple inter-connected, interacting components, and emergent properties. Simillimum individualization derives from formation of a unique personalized protein corona shell adsorbed to the reactive surface of the homeopathic nano-structures on contact with the recipient's body fluids. Low doses of such complex nano-structures initiate the adaptive processes of hormesis to mobilize endogenous healing of a disease state. The capacity for self-organization and self-similarity in complex systems is the key to future research on the nature of homeopathic medicines and systemic healing during individualized homeopathic treatment.

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Section: Homeopathic Medicines As Complex Systemsmentioning

confidence: 99%

The Complexity of the Homeopathic Healing Response Part 2: The Role of the Homeopathic Simillimum as a Complex System in Initiating Recovery from Disease

Bell

2019

Homeopathy

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“…[111] On this basis, PEC bioanalysis, as a new analytical technique, has been proved to be a good biological detection method. [112] Currently, many PEC detection methods have been developed for biomolecular detection. [113,114] For instance, a PEC biosensor for miRNA-21 detection based on cosensitization of biocompatible CuInS 2 / ZnS QDs (ZCIS QDs) and N-doped CDs (N-CDs) coupled with dual cascade toehold-mediated strand displacement amplification (dual cascade TSDA) was developed by Chu et al (Figure 8).…”

Section: Carbon Dots For Microrna Electrochemical Biosensingmentioning

confidence: 99%

Recent Applications of Carbon Nanomaterials for microRNA Electrochemical Sensing

Wang

Wen

Yan

2020

Chemistry An Asian Journal

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MicroRNA (miRNA) is an important tumor marker in the human body, and its early detection has a great influence on the survival rate of patients. Although there are many detection methods for miRNA at present such as northern blotting, real‐time quantitative polymerase chain reaction, microarrays, and others, electrochemical biosensors have the advantages of low detection cost, small instrument size, simple operation, non‐invasive detection and low consumption of reagents and solvents, and thus they play an important role in the early detection of cancer. In addition, with the development of nanotechnology, nano‐biosensors show great potential. The application of various nanomaterials in the development of electrochemical biosensor has greatly improved the detection sensitivity of electrochemical biosensor. Among them, carbon nanomaterials which have unique electrical, optical, physical and chemical properties have attracted increasing attention. In particular, they have a large surface area, good biocompatibility and conductivity. Therefore, carbon nanomaterials combined with electrochemical methods can be used to detect miRNA quickly, easily and sensitively. In this review, we systematically review recent applications of different carbon nanomaterials (carbon nanotubes, graphene and its derivatives, graphitic carbon nitride, carbon dots, graphene quantum dots and other carbon nanomaterials) for miRNA electrochemical detection. In addition, we demonstrate the future prospects of electrochemical biosensors modified by carbon nanomaterials for the detection of miRNAs, and some suggestions for their development in the near future.

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“…[139] Ultrasensitive detection of GSH was based on the photo-electrochemical (PEC) mechanism that can be used for the early diagnosis of acute myocardial infarction. [140,141] PEC sensors made of carbon dots (MS@CD) conjugated with mesoporous silica particles showed high selectivity for GSH at the concentrations as low as 57.6 nA µm −1 even in the presence of other biological fluids. The normal physiological concentration ranges of GSH are from 1.0 × 10 −3 to 10 × 10 −3 m and 1 × 10 −6 to 6 × 10 −6 m in mammalian cells and plasma of human blood, respectively.…”

Section: Detection Of Glutathione (Gsh)mentioning

confidence: 99%

Emerging Trends in Nanocarbon‐Based Cardiovascular Applications

Veerubhotla

Lee

2020

Advanced Therapeutics

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This review aims to review the biomedical applications of nanocarbons to various cardiovascular devices including implantable scaffolds, patches, and stents against coronary artery diseases (CAD). The clinical applications of nanocarbons in cardiac tissue engineering, cardiomyocyte supporting implants, biosensors for cardiovascular biomarkers, bioimaging and monitoring of pathological conditions of CAD are addressed. In addition, the current challenges in minimizing the toxicity of nanocarbon materials and alleviating techniques are discussed from a clinical perspective. A novel fabrication approach for nanocarbons in cell-laden cardiovascular stents is a promising regenerative means for the treatment of damaged infarction in CAD.

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Carbon dots based photoelectrochemical sensors for ultrasensitive detection of glutathione and its applications in probing of myocardial infarction

Cited by 101 publications

References 44 publications

The Complexity of the Homeopathic Healing Response Part 2: The Role of the Homeopathic Simillimum as a Complex System in Initiating Recovery from Disease

The Complexity of the Homeopathic Healing Response Part 2: The Role of the Homeopathic Simillimum as a Complex System in Initiating Recovery from Disease

Recent Applications of Carbon Nanomaterials for microRNA Electrochemical Sensing

Emerging Trends in Nanocarbon‐Based Cardiovascular Applications

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