Carbon Dioxide Laser Fiber for the Excision of Oral Leukoplakia

Chee, Michael; Sasaki, Clarence T.

doi:10.1177/000348941312200902

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…A similar study published by Chee and Sasaki also compared the use of cold steel and carbon dioxide laser for surgical resection of leukoplakia. They found no significant difference in their primary endpoints of resection time and blood loss 34 . These results were confirmed in our study.…”

Section: Discussionsupporting

confidence: 90%

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Flexible fiber‐based CO₂ laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery

Rosenthal

Baser

Migliacci

et al. 2021

Laryngoscope Investig Oto

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Importance This study reports the impact of laser surgery on quality of life in patients with oral cavity lesions. Objective To compare postoperative pain and quality of life in patients treated with flexible fiberoptic CO2 laser vs electrocautery in patients with oral cavity precancerous lesions and early stage cancers. Design Randomized controlled trial. Setting Single center. Participants Patients with premalignant oral cavity lesions and early stage oral cancer. Intervention Patients were randomized to have surgical resection using either flexible fiber carbon dioxide laser (Laser) or electrocautery (EC). The patients were then followed over a period of 28 days to assess for outcomes including pain, quality of life, performance status, return to work, and return to diet. Quality of life was measured by the University of Washington Quality of Life (UWQOL) questionnaire and the performance status score (PSS). Main outcome measure The primary endpoint for this study was the numerical pain rating on postoperative day (POD) 7. Results Sixty‐two patients were randomized (32 laser and 30 electrocautery). Lesions excised were carcinoma in 30(48%), dysplasia in 31(50%) and benign in 1(2%). There was no difference in the location of lesion, size of lesion, defect size, type of closure, resection time, and blood loss between Laser and EC arms. Patients who had Laser had less pain compared to EC (mean pain score on POD 7 L = 2.84 vs EC = 3.83, P = 0.11). better UW QOL scores and PSS scores, quicker return to normal diet (median days L = 26.0 vs EC = 28.5, P = 0.17) and faster return to work (median days L = 13.0 vs EC = 16.5, P = 0.14). However, these results were not statistically significant. Conclusion There was a trend for patients treated with laser to have less pain and better quality of life scores but these result were not statistically significant. Based on the actual observed difference, a large multicenter RCT with 90 patients in each arm is required to determine the clinical relevance of our results.

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Section: Discussionsupporting

confidence: 90%

“…They found no significant difference in their primary endpoints of resection time and blood loss. 34 These results were confirmed in our study. They reported no difference in postoperative pain between the groups.…”

Section: Discussionsupporting

confidence: 89%

Flexible fiber‐based CO₂ laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery

Rosenthal

Baser

Migliacci

et al. 2021

Laryngoscope Investig Oto

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show abstract

“…With regards to complications following CO 2 laser treatment, in this study, pain and granuloma formation were observed. Pain is the most frequently reported complication (Chee & Sasaki, 2013; Deppe et al, 2012; Romeo et al, 2020; Tambuwala et al, 2014). Despite this, López‐Jornet and Camacho‐Alonso (2013) concluded that pain and swelling is more frequent when using a cold scalpel than when using CO 2 laser, and unlike our study, they did not observe granuloma formation.…”

Section: Discussionmentioning

confidence: 99%

Importance of the vaporization margin during CO₂ laser treatment of oral leukoplakia: A survival study

et al. 2022

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Oral leukoplakia (OL) is one of the most common potentially malignant disorder of the oral cavity (van der Waal, 2009). It was recently defined by a WHO collaborative centre as "white plaque with a questionable risk of malignancy once all other similar clinical lesions that carry no increased risk of cancer have been excluded" (Warnakulasuriya et al., 2021). It has an estimated prevalence of 4.11% (95% CI = 1. 98-6.97;Mello et al., 2018); an annual risk of malignant transformation of between approximately 2% and 3% (Carrard & van der Waal, 2018) and the pooled proportion of malignant transformation is 9.8% (95% CI: 7.9-11.7), according to a systematic review covering the last 5 years (Aguirre-Urizar et al., 2021).When treating OL, it is important to firstly eliminate any possible etiological factors, such as tobacco or alcohol consumption. If the lesion cannot be related to any of the above, or if it persists for longer than 3 months after the aforementioned factors have been eliminated, a biopsy must be taken in order to confirm the diagnosis

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“…5 In the treatment of leukoplakias with CO 2 laser, studies have shown recurrence rates ranging from 5.3% to 40.7% and malignant transformation rates ranging from 0 to 10.2%. [6][7][8][9] Thus, it presents a wide range of results.…”

Section: Introductionmentioning

confidence: 99%

Treatment of oral leukoplakia with CO2 laser (10,600 nm): analysis of 37 cases

et al. 2022

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Carbon Dioxide Laser Fiber for the Excision of Oral Leukoplakia

Abstract: The CO2 laser fiber did not show an advantage in operative time. The CO2 laser fiber did show better outcomes in the areas of blood loss, bipolar cautery use, and intraoperative margins needed.

Cited by 10 publications

References 8 publications

Flexible fiber‐based CO₂ laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery

Flexible fiber‐based CO₂ laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery

Importance of the vaporization margin during CO₂ laser treatment of oral leukoplakia: A survival study

Treatment of oral leukoplakia with CO2 laser (10,600 nm): analysis of 37 cases

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Carbon Dioxide Laser Fiber for the Excision of Oral Leukoplakia

Abstract: The CO2 laser fiber did not show an advantage in operative time. The CO2 laser fiber did show better outcomes in the areas of blood loss, bipolar cautery use, and intraoperative margins needed.

Cited by 10 publications

References 8 publications

Flexible fiber‐based CO2 laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery

Flexible fiber‐based CO2 laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery

Importance of the vaporization margin during CO2 laser treatment of oral leukoplakia: A survival study

Treatment of oral leukoplakia with CO2 laser (10,600 nm): analysis of 37 cases

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Product

Resources

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Flexible fiber‐based CO₂ laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery

Flexible fiber‐based CO₂ laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery

Importance of the vaporization margin during CO₂ laser treatment of oral leukoplakia: A survival study