SignificanceCarbon dioxide removal through the permanent sequestration of biogenic CO2 is a critical technique for climate change mitigation, but most bioenergy with carbon capture and sequestration (CCS) technologies are technically immature or commercially unavailable. In contrast, examples of CCS of biogenic CO2 resulting from fermentation emissions already exist at scale. Here, we evaluate low-cost, commercially ready sequestration opportunities for existing biorefineries in the United States. We find that existing and proposed financial incentives suggest a substantial near-term opportunity to catalyze the growth of CCS infrastructure, improve the impacts of conventional biofuels, support development of carbon-negative biofuels, and satisfy low-carbon fuel policies.