Carbon biomedical devices

Bokros, J.C.

doi:10.1016/0008-6223(77)90324-4

Cited by 168 publications

(78 citation statements)

References 22 publications

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“…Further, they show the properties of both bioinertness and chemical stability, essential for artificial heart valve and dental implants in the body [33,34]. Therefore, CNTs composed of graphene sheets can be one of the candidates as cell culture substrates for iPS cells because of their nano-roughness which facilitates adhesion, bioinertness, chemical stability, and compatibility.…”

Section: Et Al Reported the Propagation Of Ips Cells In A Microporousmentioning

confidence: 99%

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Maintenance of hemiround colonies and undifferentiated state of mouse induced pluripotent stem cells on carbon nanotube-coated dishes

Akasaka

Yokoyama

Matsuoka

et al. 2011

Carbon

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Induced pluripotent stem (iPS) cells have attracted worldwide interest. However, there have been only a few studies investigating effective culture substrates for feeder-free culturing for the maintenance of iPS cells. In this study, we cultured mouse iPS cells under feeder-free conditions on carbon nanotube (CNT)-coated dishes and then evaluated the colony morphology and differentiation state of the cells on the dishes.After 5 d of cultivation in a medium containing 15% fetal bovine serum (FBS) and leukemia inhibitory factor (LIF), the colonies on thick films of multi-walled CNTs (MWCNTs) were observed to be hemiround; further, the cells expressed early undifferentiation markers. On the other hand, the colonies on a cell culture polystyrene dish and a collagen-coated polystyrene dish showed indistinct outline and spread well, and most spreading cells only weakly expressed early undifferentiation markers. These results indicate that the thick films of MWCNTs could maintain hemiround colonies and undifferentiated state of mouse iPS cells cultured under feeder-free conditions.

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Section: Et Al Reported the Propagation Of Ips Cells In A Microporousmentioning

confidence: 99%

“…MWCNT5 provide a grip for the cells owing to its nano-roughness [22], and the bioinert 38 substrate gently responded to the iPS cells owing to the culturing due to graphite structure [33,34].…”

mentioning

confidence: 99%

Maintenance of hemiround colonies and undifferentiated state of mouse induced pluripotent stem cells on carbon nanotube-coated dishes

Akasaka

Yokoyama

Matsuoka

et al. 2011

Carbon

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“…The morphological and structural properties of such singular material have been extensively explored in the last decades, mainly due to their wide range of applications, for example, in thermal coating of airships [1,2], bony prostheses [3], heart valves [4][5][6], molecular sieves [7], hydrogenation catalyst supports [8], among others. Besides, RVC has a low density and high electrical conductivity [9] that is very attractive for electrochemical applications as three-dimensional electrode [10].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of defects and surface structure formation in reticulated vitreous carbon

Gonçalves

Rezende

Ferreira³

2006

Braz. J. Phys.

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Morphological and microstructure properties of reticulated vitreous carbon (RVC) were analyzed by scanning electron microscopy (SEM), micro-Raman spectroscopy and x-ray diffraction (XRD) techniques as a function of heat treatment temperature (HTT). Samples produced in the HTT range of 1000 to 2400 K have demonstrated a strong dependence of HTT in their structural order mainly attributed to the presence of hydrogen and oxygen (heteroatoms), originated from precursor. In this range, the material is changed from pyropolymer to carbon. The polyfurfuryl alcohol precursor has furanic groups and its cure originates methylenical bonds and sulphur atoms. At HTT higher than 1300 K, these atoms are gradually liberated from the material generating a discrete structure ordering.

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“…1,2 CNTs have the advantage of superior mechanical strength, and carbon materials in general are considered inert and therefore biocompatible. 3,4 However, before CNTs can be incorporated into new and existing biomedical devices, their toxicity and biocompatibility need to be thoroughly investigated. Mice injected intraperitoneally with CNTs exhibited toxicological changes similar to those induced by exposure to asbestos, 5,6 and CNTs have been linked to the induction of mesotheliomas.…”

Section: Introductionmentioning

confidence: 99%

“…Biological responses according to the shape and size of carbon nanotubes in Beas-2B and MesO-1 cells hisao haniu 1,2 Naoto saito 2,3 Yoshikazu Matsuda 4 Tamotsu Tsukahara 5 Yuki Usui 1,6,7 Kayo Maruyama 2,3 seiji Takanashi …”

mentioning

confidence: 99%

Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells

Haniu¹,

Matsuda²,

Tsukahara³

et al. 2014

IJN

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This study aimed to investigate the influence of the shape and size of multi-walled carbon nanotubes (MWCNTs) and cup-stacked carbon nanotubes (CSCNTs) on biological responses in vitro. Three types of MWCNTs – VGCF ® -X, VGCF ® -S, and VGCF ® (vapor grown carbon fibers; with diameters of 15, 80, and 150 nm, respectively) – and three CSCNTs of different lengths (CS-L, 20–80 μm; CS-S, 0.5–20 μm; and CS-M, of intermediate length) were tested. Human bronchial epithelial (BEAS-2B) and malignant pleural mesothelioma cells were exposed to the CNTs (1–50 μg/mL), and cell viability, permeability, uptake, total reactive oxygen species/superoxide production, and intracellular acidity were measured. CSCNTs were less toxic than MWCNTs in both cell types over a 24-hour exposure period. The cytotoxicity of endocytosed MWCNTs varied according to cell type/size, while that of CSCNTs depended on tube length irrespective of cell type. CNT diameter and length influenced cell aggregation and injury extent. Intracellular acidity increased independently of lysosomal activity along with the number of vacuoles in BEAS-2B cells exposed for 24 hours to either CNT (concentration, 10 μg/mL). However, total reactive oxygen species/superoxide generation did not contribute to cytotoxicity. The results demonstrate that CSCNTs could be suitable for biological applications and that CNT shape and size can have differential effects depending on cell type, which can be exploited in the development of highly specialized, biocompatible CNTs.

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Carbon biomedical devices

Cited by 168 publications

References 22 publications

Maintenance of hemiround colonies and undifferentiated state of mouse induced pluripotent stem cells on carbon nanotube-coated dishes

Maintenance of hemiround colonies and undifferentiated state of mouse induced pluripotent stem cells on carbon nanotube-coated dishes

Dynamics of defects and surface structure formation in reticulated vitreous carbon

Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells

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