Carbohydrate metabolism in tissue of fresh water crab (Oziotelphusa senex senex) exposed to methyl parathion

Ps, Reddy; Bhagyalakshmi, A.; Ramamurthi, R.

doi:10.1007/bf01623496

Cited by 17 publications

(2 citation statements)

References 11 publications

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“…The inhibition of the enzyme had a linear correlation with increase in the carbaryl concentration and period of exposure. The results are in agreement with that reported in fresh water crab exposed to methyl parathion 13 and in rat treated with carbofuran 14 . The inhibition in LDH activity and rise in lactic acid levels in the tissues of carbaryl treated C. batrachus indicated that the rate of glycolysis in the tissues was higher and that of TCA cycle was lower in the teleost.…”

Section: Discussionsupporting

confidence: 95%

Changes in lactic acid content and activity of lactate dehydrogenase inclarias batrachus, exposed to carbaryl

Sharma

Gopal

1995

Toxicological & Environmental Chemistry

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Ciarias batrachus, the fresh water teleost, were exposed to subacute concentrations (1,2 and 4 mg/L) of carbaryl (LC50; 15.08 mg/L) for 96 hr and 15 days. Its effect on lactic acid content and the activity of lactate dehydrogenase (LDH) in various tissues and blood of the fish was investigated. Carbaryl at all concentrations tested and both incubation periods caused accumulation of lactic acid in different fish tissues; the level being higher at 96 hr than that at 15 days. In blood, lactic acid concentration increased in 15 days treated fish over 96 hr. the activity of LDH decreased sharply in carbaryl treated tissues. The inhibition of enzyme increased with rise in pesticide concentration as well as the duration of treatment. The toxic effect of carbaryl on LDH activity was higher in liver, heart, muscle and gills than in kidney and spleen. The results suggest significant alterations in energy metabolism of C. batrachus induced by carbaryl.

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Section: Discussionsupporting

confidence: 95%

Changes in lactic acid content and activity of lactate dehydrogenase inclarias batrachus, exposed to carbaryl

Sharma

Gopal

1995

Toxicological & Environmental Chemistry

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“…Daphnids, however, can easily be replaced in the diet of Chinook and chum yearlings and fry and are not among the top 5 types of prey items for coho, sockeye, or pink salmon (Higgs et al ). Other key prey items, such as amphipods, copepods, other species of crustaceans, and insects are much less sensitive to methyl parathion (Muncy and Oliver ; Butler ; Yasuno et al ; Eisler , ; Albaugh ; Apperson et al ; Cheah et al ; Mayer and Ellersieck ; Reddy et al ; Reddy and Rao ; Mayer ; Nichiuchi and Hashimoto ). Rather than rely on the most sensitive tested species, higher‐tier risk assessments should consider effects to the entire community of prey or habitat species for the listed species of interest.…”

Section: Introductionmentioning

confidence: 99%

Risk assessment considerations with regard to the potential impacts of pesticides on endangered species

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et al. 2014

Integr Envir Assess & Manag

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Simple, deterministic screening-level assessments that are highly conservative by design facilitate a rapid initial screening to determine whether a pesticide active ingredient has the potential to adversely affect threatened or endangered species. If a worst-case estimate of pesticide exposure is below a very conservative effects metric (e.g., the no observed effects concentration of the most sensitive tested surrogate species) then the potential risks are considered de minimis and unlikely to jeopardize the existence of a threatened or endangered species. Thus by design, such compounded layers of conservatism are intended to minimize potential Type II errors (failure to reject a false null hypothesis of de minimus risk), but correspondingly increase Type I errors (falsely reject a null hypothesis of de minimus risk). Because of the conservatism inherent in screeninglevel risk assessments, higher-tier scientific information and analyses that provide additional environmental realism can be applied in cases where a potential risk has been identified. This information includes community-level effects data, environmental fate and exposure data, monitoring data, geospatial location and proximity data, species biology data, and probabilistic exposure and population models. Given that the definition of "risk" includes likelihood and magnitude of effect, higher-tier risk assessments should use probabilistic techniques that more accurately and realistically characterize risk. Moreover, where possible and appropriate, risk assessments should focus on effects at the population and community levels of organization rather than the more traditional focus on the organism level. This document provides a review of some types of higher-tier data and assessment refinements available to more accurately and realistically evaluate potential risks of pesticide use to threatened and endangered species. Integr Environ Assess Manag 2015;11:102-117. © 2014 SETAC

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Carbofuran-induced biochemical changes inClarias batrachus

Singh

Sharma

1998

Pestic. Sci.

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:The e †ect of carbofuran, an organo-carbamate pesticide, upon the level of protein as well as the activity of lactate dehydrogenase (EC 1.1.1.28, LDH) was studied by exposing the teleost Ðsh, Clarias batrachus, to di †erent subacute concentrations (0É01 and 0É02 mg litre~1) for 96 h and 15 days. The results showed a drastic decrease in the protein content in di †erent body organs of the Ðsh. The pesticide also caused a signiÐcant decrease in the level of activity of LDH in di †erent body tissues of the Ðsh, the e †ect being more pronounced in the gills, muscle, brain and liver than in kidney and heart. The decrease in protein content and the activity of LDH in Ðsh tissues was more marked at the higher concentration of the pesticide for the longer duration of treatment. The results suggested that carbofuran has an e †ect at very low concentration (compared to its LC 50 value) possibly at the level of protein metabolism, and also inhibits the activity of LDH, the terminal glycolytic enzyme.1998 SCI ( Pestic. Sci., 53, 285È290 (1998)

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Carbohydrate metabolism in tissue of fresh water crab (Oziotelphusa senex senex) exposed to methyl parathion

Cited by 17 publications

References 11 publications

Changes in lactic acid content and activity of lactate dehydrogenase inclarias batrachus, exposed to carbaryl

Changes in lactic acid content and activity of lactate dehydrogenase inclarias batrachus, exposed to carbaryl

Risk assessment considerations with regard to the potential impacts of pesticides on endangered species

Carbofuran-induced biochemical changes inClarias batrachus

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