Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens

Zhao, Yanan; Paderu, Padmaja; Delmas, Guillaume; Dolgov, E.G.; Lee, Min Hee; Senter, Meredith; Park, Steven; Leivers, S.; Perlin, David S.

doi:10.1097/ta.0000000000000737

Cited by 25 publications

(19 citation statements)

References 16 publications

(9 reference statements)

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“…In the same study by Sabi et al [ 20 ], topically applied CHD-FvA can reduce the size of wounds infected with Staphylococcus aureus , thus stopping the progression of the infection. CHD-FvA is also suggested to reduce the size of wounds infected with antibiotic-resistant pathogens [ 23 ]. This suggests a bimodal effect of FvA that not only suppresses immune function but also stimulates it.…”

Section: Immunomodulation By Fvamentioning

confidence: 99%

Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes

Winkler

Ghosh

2018

Journal of Diabetes Research

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Chronic inflammatory diseases like diabetes are on a rise in the Western world. Based on the tsunami of new cases every year, new therapeutic measures must be considered. A promising avenue might involve the attenuation of underlying inflammation through natural health products (NHPs). This is because most NHPs have a rich history in traditional medicine and might be considered safer under appropriate doses and conditions. However, the biggest impediment in NHP research is that rarely do these products come with verified health benefits or dosing schedules established through modern scientific research. Fulvic acid (FvA), one such NHP, comes from humic substances produced by microorganisms in soil. Traditional medicine and modern research claim FvA can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function; all of which are hallmarks of diabetes. This minireview outlines the available peer-reviewed research on FvA and examines its anecdotal health claims. We show that although available research has been minimal, there is substantial evidence to pursue FvA research in preventing chronic inflammatory diseases, including diabetes.

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Section: Immunomodulation By Fvamentioning

confidence: 99%

Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes

Winkler

Ghosh

2018

Journal of Diabetes Research

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“…We chose to look at the activity of 4F because of its specificity against A. baumannii and low eukaryotic toxicity. In this study, two symmetrical 1.0-cm puncture wounds were introduced to the dorsal side muscle layer of outbred Sprague-Dawley rats ( 21 ). Vehicle control and 4F were administered topically to assess initially tolerance and potential adverse effects.…”

Section: Resultsmentioning

confidence: 99%

An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds

Vila-Farrés

Chu

Ternei

et al. 2018

mSphere

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Natural product-inspired antibiotics have saved millions of lives and played a critical role in modern medicine. However, the emergence of drug-resistant pathogens is outpacing the rate at which new clinically useful antibiotics are being discovered. The lack of a means to combat infections caused by multidrug-resistant (MDR) Acinetobacter baumannii is of particular concern. The sharp increase in cases of MDR A. baumannii infections in recent years prompted the CDC (https://www.cdc.gov/drugresistance/biggest_threats.html) and WHO (http://www.who.int/medicines/publications/global-priority-list-antibiotic-resistant-bacteria/en/) to list this pathogen as a “serious threat” and “critical pathogen,” respectively. Here we report a new antibiotic, paenimucillin C, active against Gram-negative bacterial pathogens, including many clinical isolates of MDR A. baumannii strains. Mechanistic studies point to membrane disruption leading to leakage of intracellular contents as its antibacterial mode of action. Paenimucillin C sterilizes MDR A. baumannii infections in a rat cutaneous wound model with no sign of rebound infection, providing a potential new therapeutic regimen.

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“…Crbohydrate-derived fulvic acid can prevent the progression of the wound infection. In case of fulvic acid treated macrophages, intracellular signalling was increased and stimulate immune function [47,48].…”

Section: Antioxidant and Immune Boosting Property Of Humic Substancesmentioning

confidence: 99%

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Jacob

Chandramohanakumar

2019

Int J App Pharm

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Efficiency of therapeutic compounds could be enhanced by encapsulation and covalent attachments to a biomaterial carrier. Complex formation with humic substances is valuable techniques to improve bioactivity of natural products. Fractal structures of humic substances also have adjacent carboxyl and hydroxyl groups. Along with molecular bonding property, reduction-oxidation and association-dissociation capacities of humic substances are considered this as a biomaterial for transform, other molecules, and substances. Immune system responses of humic acid stimulates in the human body. However, pharmaceutical importance of humic substances, demands on evidenced efficacy and a clearly defined chemical composition of the preparations used. Toxicological safety standards also have to be evaluated. This review summarises the application of humic substances as pharmaceuticaly important biomaterial. Research on this zone opened up an application for humic substances in pharmacogonasy.

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Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens

Abstract: CHD-FA is a promising topical remedy for drug-resistant wound infections. It accelerated the healing process of wounds infected with methicillin-resistant S. aureus and multidrug-resistant P. aeruginosa in rats, which is linked to both its antimicrobial and anti-inflammatory properties.

Cited by 25 publications

References 16 publications

Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes

Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes

An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

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