Carbohydrate antigen 19‑9 as a prognostic biomarker in pancreatic neuroendocrine tumors

Luo, Guopei; Jin, Kaizhou; He, Cheng; Liu, Chen; Guo, Meng; Yang, Chao; Xu, Jinzhi; Wang, Wenquan; Gao, Heli; Zhang, Shirong; Jiang, Long; Xu, Jin; Ni, Quanxing; Chen, Jie; Lei, Yu

doi:10.3892/ol.2017.7071

Cited by 18 publications

(18 citation statements)

References 25 publications

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“…30 CA19-9 is a tumor-associated antigen, which is a widely used marker for biliary and pancreatic cancer, initially reported by Koprowski et al 31 It has been reported as a prognostic biomarker for various tumors including GBC. [32][33][34] Although the optimal cutoff value is still controversial, the use of CA19-9 may provide an opportunity to guide personalized neoadjuvant therapy for GBC patients. 35 However, CA19-9 levels are elevated not only in the case of GBC but also in other cancers and certain inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

The predictive value of systemic immune inflammation index for postoperative survival of gallbladder carcinoma patients

Chen

Huang

Sun

et al. 2021

Journal of Surgical Oncology

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Background Growing evidence indicates that systemic immune inflammation index (SII) can predict the prognosis of various solid tumors. The objective of this study aimed to investigate the efficacy of SII in predicting the prognosis of gallbladder carcinoma (GBC) patients after radical surgery. Methods A consecutive series of 93 patients with GBC who underwent radical resection were enrolled in the retrospective study. The cutoff value for the SII was calculated using the time‐dependent receiver operating characteristic (ROC) curve analysis by overall survival (OS) prediction. The associations between the SII and the clinicopathologic characteristics were analyzed using Pearson's χ2 test and Fisher's exact test. Survival curves were calculated using the Kaplan–Meier method. Univariate analysis was performed to evaluate the prognostic relevance of preoperative parameters. The multivariate Cox regression proportional hazard model was used to assess variables significant on univariate analysis. Results The Kaplan–Meier survival analysis and the multivariate analysis of patients with GBC who received radical resection showed SII independently predicted OS. The univariate analysis showed that the TNM stage, SII, CA19‐9, ALP, prealbumin, NLR, MLR, lymph node metastasis, and histopathological type were all associated with overall survival. In time‐dependent ROC analysis, the area of the SII‐CA19‐9 under the ROC curve (AUC) was higher than that of the preoperative SII or CA19‐9 levels for the prediction of OS. Conclusion Our results demonstrate that high SII was a predictor of poor long‐term outcomes among patients with GBC undergoing curative surgery. SII‐CA19‐9 classification may be more effective in predicting the postoperative prognosis of GBC patients.

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Section: Discussionmentioning

confidence: 99%

The predictive value of systemic immune inflammation index for postoperative survival of gallbladder carcinoma patients

Chen

Huang

Sun

et al. 2021

Journal of Surgical Oncology

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“…Serum CA19-9 is a tumor-related carbohydrate biomarker, released from a human colorectal cancer cell line which is targeted by the monoclonal antibody 1116-NS-19-9. [ 23 ] The concentration of CA19-9 is correlated to the tumor mass, TNM stage, and recurrence. [ 3 ] However, it presents poor effectiveness in detecting in the early stages.…”

Section: Discussionmentioning

confidence: 99%

Identification of Serum microRNA-25 as a novel biomarker for pancreatic cancer

Tong

Zhong

et al. 2020

Medicine

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To identify serum microRNA-25 (miR-25) as a diagnostic biomarker for pancreatic cancer (PCa) and to evaluate its supplementary role with serum carbohydrate antigen 19-9 (CA19-9) in early identification of cancers. Eighty patients with pancreatic cancer and 91 non-cancer controls were enrolled in this study. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression level of miR-25. Levels of CA19-9, carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125) were measured by chemiluminescent immunoassay. The logistic model was established to evaluate the correlation of miR-25 with clinical characteristics. A risk model for PCa was conducted by R statistical software. Diagnostic utility for PCa and correlation with clinical characteristics were analyzed. The expression level of miR-25, in the PCa group was significantly higher ( P < .05). Risk Model illustrated the relation between miR-25 and pancreatic cancer. With the combination of CA19-9, the performance of miR-25 in early stages (I+II) in the diagnosis of PCa was profoundly better than CA19-9 and miR-25 alone. This combination was more effective for discriminating PCa from non-cancer controls (AUC-ROC, 0.985; sensitivity, 97.50%; specificity, 90.11%) compared with CA19-9 alone or the combination of CA19-9 and CA125. The expression level of miR-25 among pancreatic cancer patients was significantly higher than that in the control group. miR-25 existed as one of the most relevant factors of PCa. miR-25 can serve as a novel noninvasive approach for PCa diagnosis, and with the supplementary of CA19-9, the combination was more effective, especially in early tumor screening.

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“…In particular, CA199 can promote leukocyte aggregation by regulating leukocyte migration and adhesion in inflammatory regions[ 11 ]. As one of the common tumor markers, CA199 is mainly used in the auxiliary diagnosis and evaluation of disease progression and prognosis of pancreatic cancer, colorectal cancer, and other diseases[ 12 - 13 ]. In recent years, the abnormally elevated CA199 in some non-cancerous benign diseases has drawn increasing attention[ 14 - 16 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis

Mei

Chen

Peng

et al. 2018

WJCC

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AIMTo investigate the diagnostic value of abnormal serum carbohydrate antigen 199 (CA199) level in acute cholangitis secondary to choledocholithiasis.METHODSIn this retrospective cohort study, the clinical data of 727 patients with choledocholithiasis admitted to the Third Affiliated Hospital of Zunyi Medical College from June 2011 to June 2017 were collected. Among these patients, 258 patients had secondary acute cholangitis and served as observation group, and the remaining 569 choledocholithiasis patients served as the control group. Serum liver function indexes and tumor markers were detected in both groups, and the receiver operating characteristic (ROC) curves were constructed for markers showing statistical significances. The cutoff value, sensitivity, and specificity of each marker were calculated according to the ROC curves.RESULTSThe results of liver function tests showed no significant differences between the two groups (P > 0.05). Tumor markers including serum CA125, CA153, carcinoembryonic antigen, and alpha fetoprotein levels were also not significantly different (P > 0.05); however, the serum CA199 level was significantly higher in the observation group than in the control group (P < 0.05). The ROC curve analysis showed that the area under the curve was 0.885 (95%CI: 0.841-0.929) for CA199, and the cutoff value of 52.5 kU/L had the highest diagnostic accuracy, with a sensitivity of 86.8% and a specificity of 81.6%.CONCLUSIONAbnormally elevated serum CA199 level has an important value in the diagnosis of acute cholangitis secondary to choledocholithiasis. It may be a specific inflammatory marker for acute cholangitis.

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Carbohydrate antigen 19‑9 as a prognostic biomarker in pancreatic neuroendocrine tumors

Cited by 18 publications

References 25 publications

The predictive value of systemic immune inflammation index for postoperative survival of gallbladder carcinoma patients

The predictive value of systemic immune inflammation index for postoperative survival of gallbladder carcinoma patients

Identification of Serum microRNA-25 as a novel biomarker for pancreatic cancer

Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis

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