Carbimazole and the Autoimmune Response in Graves' Disease

McGregor, A M; Petersen, Meryl M.; McLachlan, Sandra M.; Rooke, P.; Smith, Bernard Rees; Hall, R.

doi:10.1056/nejm198008073030603

Cited by 256 publications

(87 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…-not detect interleukin-1 in these supernatants (not shown). The effect MMI has during suppression therapy of GD in vivo and on antibody synthesis in vitro (McGregor et al 1980) has been attributed to immuno-suppressive effects. In our hands, MMI and PC have no effect on class-II expression of TECs.…”

Section: Resultsmentioning

confidence: 99%

Modulation of class-II antigen expression in human thyroid epithelial cell cultures

Wenzel¹,

Arnholdt²,

Grammerstorf³

et al. 1987

Acta Endocrinologica

View full text Add to dashboard Cite

Abstract. The modulation of HLA-D expression of thyroid epithelial cells (TEC) was studied in vitro by means of immunofluorescence. Under serum-free culture conditions, TSH and TSH-receptor antibodies induce HLA-D on TECs derived from GD-patients. Serum-free culture conditions provide a higher availability of TSH-receptors by a 'right side right' polarity of the cellular morphology. There was no evidence for IFN-γ producing cell contaminations on GD-TECs. TSH in contrast to IFN-γ does not induce HLA-DQ on TECs. HLA-DQ is not displayed by spontaneously class-II antigen expressing GD-TECs. Methimazole as well as perchlorate do not suppress HLA-D expression of TECs.

show abstract

Section: Resultsmentioning

confidence: 99%

Modulation of class-II antigen expression in human thyroid epithelial cell cultures

Wenzel¹,

Arnholdt²,

Grammerstorf³

et al. 1987

Acta Endocrinologica

View full text Add to dashboard Cite

show abstract

“…Thyroid autoimmunity as measured by thyroid autoantibodies usually decreases with anti-thyroid drug treatment or thyroid surgery (10,11), suggesting an intrathyroidal origin of thyroid autoimmunity. However, a number of patients do not demonstrate decreases in thyroid autoantibodies after medical or surgical treatment, indicating extra-thyroidal influence in thyroid autoimmunity.…”

Section: Discussionmentioning

confidence: 99%

The relationship between circulating estradiol and thyroid autoimmunity in males

Chailurkit¹,

Aekplakorn

Ongphiphadhanakul

2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Introduction: Although autoimmune thyroid disease is less common in males, it is unclear whether estrogen contributes to the difference in susceptibility among males. Objective: To examine whether circulating estradiol (E 2 ) is related to thyroid autoimmunity in males. Patients and methods: One-thousand two-hundred and sixty-three males aged 15-94 years were studied. Serum levels of E 2 , TSH receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), free thyroxine (FT 4 ), and TSH were measured by ELISA. Results: Circulating E 2 varied widely in males, ranging 18.4-403.7 pmol/l with a mean value of 136.2G51.7 pmol/l. E 2 increased with age (rZ0.18, P!0.001). No relationship between E 2 and BMI was found. When comparing the difference in E 2 according to the test results of TRAb, TPOAb, and TgAb, it was found that E 2 was significantly higher in subjects with positive TRAb (TRAb positive, E 2 Z170.3G59.8 pmol/l; TRAb negative, E 2 Z134.0G50.6 pmol/l; P!0.001). No difference in E 2 was demonstrated according to the results of TPOAb or TgAb. Logistic regression analysis showed that E 2 was a determinant of positive TRAb, independent of age and BMI. There was no relationship between serum E 2 and TSH or FT 4 . However, E 2 was negatively related to TSH (rZK0.45, P!0.01) in subjects whose TSH levels fell below the reference range (0.3-4.2 mIU/l).

show abstract

“…When patients become euthyroid after medication or surgery the majority will gradually enter remission of TSHreceptor autoimmunity. However, other possible mechanisms for remission have been proposed (19).…”

Section: Discussionmentioning

confidence: 99%

TSH-receptor autoimmunity in Graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study

Laurberg

Wallin²,

Tallstedt³

et al. 2008

European Journal of Endocrinology

357

231

View full text Add to dashboard Cite

Introduction: Autoimmunity against the TSH receptor is a key pathogenic element in Graves' disease. The autoimmune aberration may be modified by therapy of the hyperthyroidism. Objective: To compare the effects of the common types of therapy for Graves' hyperthyroidism on TSHreceptor autoimmunity. Methods: Patients with newly diagnosed Graves' hyperthyroidism aged 20-55 years were randomized to medical therapy, thyroid surgery, or radioiodine therapy (radioiodine was only given to patients R35 years of age). L-thyroxine (L-T 4 ) was added to therapy as appropriate to keep patients euthyroid. Anti-thyroid drugs were withdrawn after 18 months of therapy. TSH-receptor antibodies (TRAb) in serum were measured before and for 5 years after the initiation of therapy. Results: Medical therapy (nZ48) and surgery (nZ47) were followed by a gradual decrease in TRAb in serum, with the disappearance of TRAb in 70-80% of the patients after 18 months. Radioiodine therapy (nZ36) led to a 1-year long worsening of autoimmunity against the TSH receptor, and the number of patients entering remission of TSH-receptor autoimmunity with the disappearance of TRAb from serum during the following years was considerably lower than with the other types of therapy. Conclusion: The majority of patients with Graves' disease gradually enter remission of TSH-receptor autoimmunity during medical or after surgical therapy, with no difference between the types of therapy. Remission of TSH-receptor autoimmunity after radioiodine therapy is less common.

show abstract

Carbimazole and the Autoimmune Response in Graves' Disease

Cited by 256 publications

References 20 publications

Modulation of class-II antigen expression in human thyroid epithelial cell cultures

Modulation of class-II antigen expression in human thyroid epithelial cell cultures

The relationship between circulating estradiol and thyroid autoimmunity in males

TSH-receptor autoimmunity in Graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study

Contact Info

Product

Resources

About