Carbetocin versus oxytocin in the management of atonic post partum haemorrhage (PPH) after vaginal delivery: a randomised controlled trial

Maged, Ahmed M.; Hassan, AbdelGany; Shehata, Nesreen A.A.

doi:10.1007/s00404-015-3911-y

Cited by 18 publications

(19 citation statements)

References 19 publications

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“…According to another important parameter which is ≥1,000 mL PPH, we did not dedect any statistically significant difference between the bleeding rates in our study similar to the findings of Whigham, Attilakos and Maged et al 9,13,18 On the other hand, in another study, ratio of hemorrhage ≥1,000 mL was found to be 5.4% (15/276) in the carbetocin group and 3.7% (10/271) in the oxytocin group (p=0.33) and this different result attributed to the discontinuation or rapid administration of uterotonic medical treatment for 6 hours postoperatively. 12 One of the most valuable parameter used to compare the efficacy of uterotonics is the requirement for additional uterotonic drugs.…”

Section: Discussionsupporting

confidence: 88%

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Carbetocin Versus Oxytocin for Prevention of Postpartum Hemorrhage in Cesarean Section

Gürsoy¹,

İlter²,

Çelik³

et al. 2021

J Clin Obstet Gynecol

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This research article was produced from the thesis with the heading of "Comparison of efficiency and side effect profile of carbetocin and oxytocin in patients who underwent caesarean section under general anesthesia". ABS TRACT Objective:We aimed to compare the haemodynamic effects of carbetocin and oxytocin in preventing postpartum hemorrhage during cesarean delivery. Material and Methods: This study was conducted retrospectively in a university hospital. Women in the carbetocin group (n=42) and women in the oxytocin group (n=78) were evaluated in terms of changes in hemoglobin level, hematocrit level, uterotonic need, urine output, blood transfusion requirement, hospital stay, postoperative fever and need for peripartum hysterectomy. Results: There was not statistically significant difference between their additional uterotonic need but preoperative and postoperative 24 th hour hemoglobin reduction, calculated estimated blood loss and platelet count diminution percentage were significantly lower in the carbetocin group compared to oxytocin group (p=0.044; p=0.042; p=0.004, respectively). Besides that, the rate of blood loss of ≥500 mL was lower but not significantly different in patients receiving carbetocin compared to those using oxytocin (p=0.059) and the duration to reach 1,500 cc urine output of carbetocin group was significantly lower than the oxytocin group (p=0.001). Conclusion: Carbetocin appears to be more effective in the hemoglobin reduction, platelet reduction and calculated estimated blood loss. In addition, another advantage of carbetocin is that it has lower negative effects on urine output than oxytocin. It is noteworthy that carbetocin administration can prevent postpartum hemorrhage in appropriate cases.

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Section: Discussionsupporting

confidence: 88%

“…12 In addition, in a study performed in patients who delivered vaginally, a patient in the oxytocin arm required uterus artery ligation and internal iliac artery ligation due to PPH. 18 In our study, no additional surgical intervention was required.…”

Section: Discussionmentioning

confidence: 69%

Carbetocin Versus Oxytocin for Prevention of Postpartum Hemorrhage in Cesarean Section

Gürsoy¹,

İlter²,

Çelik³

et al. 2021

J Clin Obstet Gynecol

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“…In agree with our results Maged et al 12 reported that no statistically significance difference between both groups regarding the need for blood transfusion (12% vs 18%) with p-value: 0.401.…”

Section: The Explanationsupporting

confidence: 93%

“…In consistence with our findings regarding Hb concentration and HCT percent was Maged et al 12 who reported in their study was on 100 pregnant women who underwent vaginal delivery that there was no significant difference between Hb before delivery in carbetocin group versus that in oxytocin group with p-value: 0.55. And there was no significance difference between both groups regarding Hb 24 hour after delivery with p-value: 0.645.…”

Section: The Explanationsupporting

confidence: 91%

Carbetocin Versus Oxytocin in Prevention of Atonic Postpartum Hemorrhage

Elgarhy

Mohamed

Abdelfatah

2020

Al-Azhar International Medical Journal

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Background: Pregnancy related deathsareconsidered one of the chiefcauses of premature women's death worldwide as about 500000 ladies diedyearlyfrom this cause, about 25.0% of these mortalities are due to hemorrhage. Aim of the work: Comparison of the safety and effectiveness of carbetocin over oxytocin in prevention of postpartum Hemorrhagedue to uterine atony after vaginal deliveries and cesarean sections. Patients and Methods: : This computerized random cross sectional prospective comparative study included a total 400 pregnant women who were going to deliver, attending at Obstetric and Gynecological

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“…Low availability compounded by poor quality threatens the quality of care that can be offered to women 25 26. Trials with the room temperature stable carbetocin offer promise of a more reliably effective treatment for the prevention of postpartum haemorrhage and may contribute to improvements in maternal survival 27 28…”

Section: Discussionmentioning

confidence: 99%

Poor availability of essential medicines for women and children threatens progress towards Sustainable Development Goal 3 in Africa

Droti

O’Neill

Mathai³

et al. 2019

BMJ Glob Health

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BackgroundMost maternal and child deaths are preventable or treatable with proven, cost-effective interventions for infectious diseases and maternal and neonatal complications. In 2015 sub-Saharan Africa accounted for up to 66% of global maternal deaths and half of the under-five deaths. Access to essential medicines and commodities and trained healthcare workers to provide life-saving maternal, newborn and post-natal care are central to further reductions in maternal and child mortality.MethodsAvailable data for 24 priority medicines for women and children were extracted from WHO service availability and readiness assessments conducted between 2012 and 2015 for eight countries in sub-Saharan Africa. The mean availability of medicines in facilities stating they provide services for women or children and differences by facility type, ownership and location are reported.ResultsThe mean availability of 12 priority essential medicines for women ranged from 22% to 40% (median 33%; IQR 12%) and 12 priority medicines for children ranged from 28% to 57% (median 50%; IQR 14%). Few facilities (<1%) had all nominated medicines available. There was higher availability of priority medicines for women in hospitals than in primary care facilities: range 32%–80% (median 61%) versus 20%–39% (median 23%) and for children’s medicines 31%–71% (median 58%) versus 27%–57% (median 48%). Availability was higher in public than private facilities: for women’s medicines, range 21%–41% (median 34%) versus 4%–36% (median 27%) and for children’s medicines 28%–58% (median 51%) versus 5%–58% (median 46%). Patterns were mixed for rural and urban location for the priority medicines for women, but similar for children’s medicines.ConclusionsThe survey results show unacceptably low availability of priority medicines for women and children in the eight countries. Governments should ensure the availability of medicines for mothers and children if they are to achieve the health sustainable development goals.

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Carbetocin versus oxytocin in the management of atonic post partum haemorrhage (PPH) after vaginal delivery: a randomised controlled trial

Abstract: Carbetocin is a better alternative to oxytocin in management of atonic PPH with non-significant hemodynamic changes or side effects .

Cited by 18 publications

References 19 publications

Carbetocin Versus Oxytocin for Prevention of Postpartum Hemorrhage in Cesarean Section

Carbetocin Versus Oxytocin for Prevention of Postpartum Hemorrhage in Cesarean Section

Carbetocin Versus Oxytocin in Prevention of Atonic Postpartum Hemorrhage

Poor availability of essential medicines for women and children threatens progress towards Sustainable Development Goal 3 in Africa

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