Carbazochrome sodium sulphonate (AC-17) decreases the accumulation of tissue-type plasminogen activator in culture medium of human umbilical vein endothelial cells

Hemostatic and Anti-Inflammatory Effects of Carbazochrome Sodium Sulfonate in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Trial

“…CSS reduces permeability and enhances contractility of capillaries [11]. Only 2 previous studies have evaluated the hemostatic effect of CSS in TKA, with both showing CSS to have a beneficial effect on hemostatic, with no increased risk of asymptomatic DVT [12,35].…”

“…Carbazochrome sodium sulfonate (CSS) is a capillary stabilizer that reduces capillary permeability and enhances contraction of broken capillary ends [11,12]. It is used to treat bleeding diseases of the urinary system, upper digestion, respiratory tract, and in obstetrics and gynecology [13,14].…”

Mortality and hemorrhagic complications associated with radiofrequency ablation for treatment of hepatocellular carcinoma in patients on hemodialysis for end‐stage renal disease: A nationwide survey

“…Comparison of usage of platelet infusion or hemostat agents. We also investigated the usage of platelet infusion or hemostat agents (tranexamic acid, 24 carbazochrome sodium sulfonate hydrate, 25 and viamin K 26 ) for the prevention of hemorrhage. Usage rate of hemostat agent in non-dialyzed patients was significantly higher than that in dialyzed ESRD patients (63.2% vs 55.6%, P = 0.006) ( Table 5).…”

Effect of carbazochrome sodium sulfonate combined with tranexamic acid on blood loss and inflammatory response in patients undergoing total hip arthroplasty

“…Carbazochrome sodium sulfonate (CSS) can be used to treat bleeding due to its ability to increase capillary permeability and enhance the contraction of broken ends of capillaries. 12 , 13 Although the mechanism of action is still unclear, recent studies have shown that it could reverse thrombin-, trypsin-, and bradykinin-induced increase of endothelial cell permeability by reducing the formation of intracellular actin stress fibres and restoring tight cellular connectivity. 14 , 15 Furthermore, CSS is also used in urology, otolaryngology, etc., and studies have shown that CSS can improve symptoms of nose bleeding as well as pain and post-urination symptoms in patients with refractory chronic prostatitis.…”