Hemostatic and Anti-Inflammatory Effects of Carbazochrome Sodium Sulfonate in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Trial

Luo, Yue; Zhao, Xin; Yeersheng, Releken; Yang, Zhouyuan; Pei, Fuxing; Kang, Pengde

doi:10.1016/j.arth.2019.07.045

Cited by 17 publications

(16 citation statements)

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“…In this study, pain scores were found to be lower in the groups that used CSS (groups A to C) than the group without CSS (group D) (p = 0.050, one-way ANOVA with post hoc Bonferroni test), which suggested that CSS could reduce postoperative pain after THA, similar to the results reported in other studies. 16 , 33 However, the statistically significant differences in pain scores among the groups did not reach the minimum clinically significant difference (MCID) of 18.6 mm. 38 Therefore, the difference in pain score had no clinical significance.…”

Section: Discussionmentioning

confidence: 94%

“…We found that there is no reported previous study evaluating the haemostatic effect of CSS following THA, although some studies reported that CSS combined with TXA was effective at improving haemostasis after total knee arthroplasty surgery. 18 , 32 , 33 Therefore, to our knowledge, this is the first study evaluating perioperative haemostasis and anti-inflammatory effects using CSS and TXA in patients undergoing THA.…”

Section: Discussionmentioning

confidence: 97%

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Effect of carbazochrome sodium sulfonate combined with tranexamic acid on blood loss and inflammatory response in patients undergoing total hip arthroplasty

Luo

Yang

Yeersheng

2021

Bone & Joint Research

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Aims The purpose of this study was to examine the efficacy and safety of carbazochrome sodium sulfonate (CSS) combined with tranexamic acid (TXA) on blood loss and inflammatory responses after primary total hip arthroplasty (THA), and to investigate the influence of different administration methods of CSS on perioperative blood loss during THA. Methods This study is a randomized controlled trial involving 200 patients undergoing primary unilateral THA. A total of 200 patients treated with intravenous TXA were randomly assigned to group A (combined intravenous and topical CSS), group B (topical CSS), group C (intravenous CSS), or group D (placebo). Results Mean total blood loss (TBL) in groups A (605.0 ml (SD 235.9)), B (790.9 ml (SD 280.7)), and C (844.8 ml (SD 248.1)) were lower than in group D (1,064.9 ml (SD 318.3), p < 0.001). We also found that compared with group D, biomarker level of inflammation, transfusion rate, pain score, and hip range of motion at discharge in groups A, B, and C were significantly improved. There were no differences among the four groups in terms of intraoperative blood loss (IBL), intramuscular venous thrombosis (IMVT), and length of hospital stay (LOS). Conclusion The combined application of CSS and TXA is more effective than TXA alone in reducing perioperative blood loss and transfusion rates, inflammatory response, and postoperative hip pain, results in better early hip flexion following THA, and did not increase the associated venous thromboembolism (VTE) events. Intravenous combined with topical injection of CSS was superior to intravenous or topical injection of CSS alone in reducing perioperative blood loss. Cite this article: Bone Joint Res 2021;10(6):354–362.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Effect of carbazochrome sodium sulfonate combined with tranexamic acid on blood loss and inflammatory response in patients undergoing total hip arthroplasty

Luo

Yang

Yeersheng

2021

Bone & Joint Research

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“…Theoretically, CSS decreases capillary permeability and increases capillary resistance ( 4 ), which may decrease the hemorrhaging time. The hemostatic effect of CSS has been suggested since at least the 1960s ( 5 ), and CSS has been used to treat bleeding in the gastrointestinal and respiratory tracts or during obstetrical surgery ( 6 ), orthopedic surgery ( 7 ), and abdominal surgery ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…A recent randomized controlled trial by Luo et al showed that CSS reduced perioperative blood loss in patients undergoing total knee arthroplasty, without thromboembolic complications ( 7 ). One small observational case-only study reported that CSS may have improved bleeding symptoms in patients with hereditary hemorrhagic telangiectasia ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Carbazochrome Sodium Sulfonate in Patients with Colonic Diverticular Bleeding: Propensity Score Matching Analyses Using a Nationwide Inpatient Database

et al. 2020

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Objective Carbazochrome sodium sulfonate (CSS) has been routinely used to treat bleeding; however, no study has examined the effect of CSS for gastrointestinal bleeding. Therefore, we aimed to investigate the effect of CSS for colonic diverticular bleeding. Methods We performed a nationwide observational study using the Japanese Diagnosis Procedure Combination inpatient database. We identified patients who were admitted for diverticular bleeding from July 2010 to March 2018. Patients who received CSS on the day of admission were defined as the CSS group, and those not receiving CSS were defined as the control group. The primary outcome was in-hospital mortality. Secondary outcomes were length of stay, total costs, and blood transfusion within 7 days of admission. Propensity score matching analyses were performed to compare outcomes between the two groups. Results A total of 59,965 patients met our eligibility criteria. Of these, 14,437 (24%) patients received CSS on the day of admission. One-to-one propensity score matching created 14,379 matched pairs. There was no significant difference in the in-hospital mortality between the CSS and control groups (0.6% vs. 0.5%, respectively; odds ratio: 0.96; 95% confidence interval: 0.72-1.29). The length of stay was longer in the CSS group than in the control group (11.4 vs. 11.0 days, respectively; difference: 0.44; 95% confidence interval: 0.14-0.73). There were no significant differences in the total costs or the proportion of patients receiving blood transfusion between the groups. Conclusions CSS may not reduce in-hospital mortality, length of stay, total costs, or the need for blood transfusion in patients with colonic diverticular bleeding.

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“…Nifuroxazide (Figure 1c), which has been used to treat diarrhea, colitis, and cancer, also contains the N-acylhydrazone moiety. [5] The antimicrobial compound nitrofurazone (Figure 1d) [6] and the hemostatic anti-inflammatory agent carbazochrome (Figure 1e) [7] also have the Nacylhydrazone moiety. Furthermore, several compounds containing a pyrazole moiety have been reported to show anticancer activity.…”

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confidence: 99%

¹H and ¹³C NMR spectral assignment of 29 N′‐(3‐([1,1′‐biphenyl]‐4‐yl)‐1‐phenyl‐1H‐pyrazol‐4‐yl)acylhydrazones

Park

Ahn

Lee

et al. 2020

Magnetic Reson in Chemistry

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Hemostatic and Anti-Inflammatory Effects of Carbazochrome Sodium Sulfonate in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Trial

Cited by 17 publications

References 46 publications

Effect of carbazochrome sodium sulfonate combined with tranexamic acid on blood loss and inflammatory response in patients undergoing total hip arthroplasty

Effect of carbazochrome sodium sulfonate combined with tranexamic acid on blood loss and inflammatory response in patients undergoing total hip arthroplasty

The Effect of Carbazochrome Sodium Sulfonate in Patients with Colonic Diverticular Bleeding: Propensity Score Matching Analyses Using a Nationwide Inpatient Database

¹H and ¹³C NMR spectral assignment of 29 N′‐(3‐([1,1′‐biphenyl]‐4‐yl)‐1‐phenyl‐1H‐pyrazol‐4‐yl)acylhydrazones

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Hemostatic and Anti-Inflammatory Effects of Carbazochrome Sodium Sulfonate in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Trial

Cited by 17 publications

References 46 publications

Effect of carbazochrome sodium sulfonate combined with tranexamic acid on blood loss and inflammatory response in patients undergoing total hip arthroplasty

Effect of carbazochrome sodium sulfonate combined with tranexamic acid on blood loss and inflammatory response in patients undergoing total hip arthroplasty

The Effect of Carbazochrome Sodium Sulfonate in Patients with Colonic Diverticular Bleeding: Propensity Score Matching Analyses Using a Nationwide Inpatient Database

1H and 13C NMR spectral assignment of 29 N′‐(3‐([1,1′‐biphenyl]‐4‐yl)‐1‐phenyl‐1H‐pyrazol‐4‐yl)acylhydrazones

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¹H and ¹³C NMR spectral assignment of 29 N′‐(3‐([1,1′‐biphenyl]‐4‐yl)‐1‐phenyl‐1H‐pyrazol‐4‐yl)acylhydrazones