Carbapenem-resistantAcinetobacter baumanniiST78 with OXA-72 carbapenemase and ESBL geneblaCTX-M-115: Table 1.

Pfeifer, Yvonne; Hunfeld, Klaus-Peter; Borgmann, Stefan; Maneg, Daniela; Blobner, Wolfgang; Werner, Guido; Higgins, Paul G.

doi:10.1093/jac/dkv462

Cited by 18 publications

(11 citation statements)

References 11 publications

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“…Identification of A. baumannii has been done mostly by the VITEK-2 system, MALDI-TOF [18,26] and detection of the intrinsic blaOXA-51-like gene [30]. Phenotypic antibiotic sensitivity testing (AST) was performed with the VITEK-2 platform, E-test [28], disk diffusion method [24], antibiotic gradient test and micro-broth dilution using Micronaut-S system [22]. The National Committee for Clinical Laboratory Standards (NCCLS) broth microdilution method and the respective breakpoints were used until 2006 [52].…”

Section: Identification Of a Baumannii And Antibiotic Susceptibilitymentioning

confidence: 99%

“…The first isolation of a blaNDM-1 strain was reported in 2007 in Frankfurt [47] and then in ten other studies. Additionally, Guiana extended-spectrum β-lactamases (GES-11) [41], Cefotaxime Hydrolyzing Capabilities (CTX-M) β-lactamases [28], Temoneira (TEM) and Plasmid-Mediated Quinolone Resistance (PMQR) [35], German imipenemase (GIM-1), VIP-2 and Verona integron-encoded-metallo-β-lactamase (VIM-2) [32] and blaADC-25-like [18] have been described in A. baumannii (Table 3). Figure 3 represents the chronological emergence of resistance to carbapenems, colistin, tigecycline and quinolones antibiotics as well as the resistance genes according to time of sampling or time of reporting if the time of sampling is not available.…”

Section: Resistance Genes In a Baumanniimentioning

confidence: 99%

“…Followed by IC-7 and IC-1, each was reported in two studies, while IC-4 and IC-6, each was identified only in one study. IC-2 was detected in five studies alone [16,19,27,33,42] and in combination with IC-6 once [28] and with IC-1, IC-7 and IC-4 in another study during the investigation of strains collected from different laboratories in the years 2005, 2007 and 2009 [39]. Only six sequence types of A. baumannii have been reported in the reviewed articles.…”

Section: Clonality and Sequence Typingmentioning

confidence: 99%

“…ST195 and ST218 were identified in an outbreak involving ten patients in Leverkusen [30]. ST944/ST78 and ST348/ST2 were determined in three isolates recovered from two patients hospitalized in Bavaria and Hesse [28].…”

Section: Clonality and Sequence Typingmentioning

confidence: 99%

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Spatio-Temporal Distribution of Acinetobacter baumannii in Germany—A Comprehensive Systematic Review of Studies on Resistance Development in Humans (2000–2018)

et al. 2020

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Acinetobacter (A.) baumannii has gained global notoriety as a significant nosocomial pathogen because it is frequently associated with multi-drug resistance and hospital-based outbreaks. There is a substantial difference in the incidence of A. baumannii infections between different countries and within Germany. However, its continuous spread within Germany is a matter of concern. A systematic literature search and analysis of the literature published between 2000 and 2018 on A. baumannii in humans was performed. Forty-four studies out of 216 articles met the criteria for inclusion, and were selected and reviewed. The number of published articles is increasing over time gradually. Case reports and outbreak investigations are representing the main body of publications. North Rhine-Westphalia, Hesse and Baden-Wuerttemberg were states with frequent reports. Hospitals in Cologne and Frankfurt were often mentioned as specialized institutions. Multiresistant strains carrying diverse resistance genes were isolated in 13 of the 16 German states. The oxacillinase blaOXA-23-like, intrinsic blaOXA-51-like, blaOXA-58 variant, blaNDM-1, blaGES-11, blaCTX-M and blaTEM are the most predominant resistance traits found in German A. baumannii isolates. Five clonal lineages IC-2, IC-7, IC-1, IC-4 and IC-6 and six sequence types ST22, ST53, ST195, ST218, ST944/ST78 and ST348/ST2 have been reported. Due to multidrug resistance, colistin, tigecycline, aminoglycosides, fosfomycin, ceftazidime/avibactam and ceftolozan/tazobactam were often reported to be the only effective antibiotics left to treat quadruple multi-resistant Gram-negative (4MRGN) A. baumannii. Dissemination and infection rates of A. baumannii are on the rise nationwide. Hence, several aspects of resistance development and pathogenesis are not fully understood yet. Increased awareness, extensive study of mechanisms of resistance and development of alternative strategies for treatment are required. One-Health genomic surveillance is needed to understand the dynamics of spread, to identify the main reservoirs and routes of transmission and to develop targeted intervention strategies.

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Section: Identification Of a Baumannii And Antibiotic Susceptibilitymentioning

confidence: 99%

Section: Resistance Genes In a Baumanniimentioning

confidence: 99%

Section: Clonality and Sequence Typingmentioning

confidence: 99%

Section: Clonality and Sequence Typingmentioning

confidence: 99%

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Spatio-Temporal Distribution of Acinetobacter baumannii in Germany—A Comprehensive Systematic Review of Studies on Resistance Development in Humans (2000–2018)

et al. 2020

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“…Another genotype included 4 isolates from 3 cities and corresponded to CC944 OXF /ST78 PAS . The strains of this genetic lineage are widespread in the territory of Russia and Belarus [12] and, according to the literature, were found in Italy, the US, and Germany [20–23]. This allows considering this genotype as a new international clone.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology and Genetic Diversity of Colistin Nonsusceptible Nosocomial Acinetobacter baumannii Strains from Russia for 2013-2014

Sheck

Edelstein

Сухорукова

et al. 2017

Canadian Journal of Infectious Diseases and Medical Microbiolog

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A high level of resistance to carbapenems in Acinetobacter baumannii strains severely limits therapeutic possibilities. Colistin is the last resort drug against such strains, although the cases of resistance to this drug have become more frequent. This article presents the epidemiological features and genetic diversity of colistin nonsusceptible A. baumannii strains collected as part of a national multicenter epidemiological study of the antibiotic resistance of pathogens of nosocomial infections (MARATHON), which was conducted in 2013-2014 in Russia. A total of 527 A. baumannii isolates were collected, 10 (1.9%) of which were nonsusceptible to colistin. The majority of nonsusceptible A. baumannii isolates to colistin showed resistance to carbapenems and had the genes of the acquired OXA-40-like carbapenemases (n = 6). In one case, a combination of OXA-23-like + OXA-40-like (n = 1) genes was identified. One strain had the multidrug-resistant (MDR) phenotype, 6 isolates had extensively drug-resistant (XDR) phenotype, and 3 isolates had pandrug-resistant (PDR) phenotype. Among the colistin nonsusceptible A. baumannii isolates, 6 individual genotypes were identified, most of which belonged to successful international clones (CC92OXF/CC2PAS, n = 4; CC944OXF/ST78PAS, n = 4; CC109OXF/CC1PAS, n = 1).

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Comparative phylo-pangenomics reveals generalist lifestyles in representative Acinetobacter species and proposes candidate gene markers for species identification

Almeida

Furlan

Stehling

et al. 2021

Gene

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Carbapenem-resistantAcinetobacter baumanniiST78 with OXA-72 carbapenemase and ESBL genebla_CTX-M-115: Table 1.

Cited by 18 publications

References 11 publications

Spatio-Temporal Distribution of Acinetobacter baumannii in Germany—A Comprehensive Systematic Review of Studies on Resistance Development in Humans (2000–2018)

Spatio-Temporal Distribution of Acinetobacter baumannii in Germany—A Comprehensive Systematic Review of Studies on Resistance Development in Humans (2000–2018)

Epidemiology and Genetic Diversity of Colistin Nonsusceptible Nosocomial Acinetobacter baumannii Strains from Russia for 2013-2014

Comparative phylo-pangenomics reveals generalist lifestyles in representative Acinetobacter species and proposes candidate gene markers for species identification

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