Carbapenem non-susceptible Klebsiella pneumoniae from Micronet network hospitals, Italy, 2009 to 2012

Sisto, Annamaria; D’Ancona, Fortunato; Meledandri, Marcello; Pantosti, Annalisa; Rossolini, G. M.; Raglio, Alfredo; Serra, Roberto; Dematte, L; Aiello, EC; Goglio, Antonio

doi:10.2807/ese.17.33.20247-en

Cited by 33 publications

(13 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, patients who developed MDR infection of gram negative/gram positive organisms were outpatients, thus needing a more in-depth analysis to address this issue as treatment options for CAP with MDR Enterobacterales, Pseudomonas aeruginosa and Acinetobacter spp are limited due to lack of appropriate antibiotics 31,32 . Increasing carbapenem resistance in gram negative isolates from BAL samples has been seen in few studies similar to present study 33,34 .…”

Section: Discussionsupporting

confidence: 84%

Microbiota of Bronchoalveolar Lavage Samples from Patients of Lower Respiratory Tract Infection – A Changing Trend

Inamdar¹,

Anuradha²,

Inamdar³

et al. 2021

J. Pure Appl. Microbiol.

View full text Add to dashboard Cite

Bronchoalveolar lavage (BAL) is the saline wash of the bronchial tree, which aids in diagnosing various pulmonary pathologies. The present study was contemplated with an aim to know the clinical, microbiological profile of BAL samples along with its sensitivity pattern and to assess its utility as a diagnostic tool. This was a prospective observational study, carried over 90 patients presenting with lower respiratory tract infections. The total microbial recovery rate from BAL was 39 (43.3%). The sensitivity, specificity and positive predictive value of BAL were found to be 76.4%, 89.7% and 90.6% respectively. Maximum isolates were bacteria (25.5%) followed by Mycobacterium tuberculosis (MTB) (16.6%) and fungi (1.1%). Predominant bacterial isolates were Gram-negative (81.5%) compared to Gram-positive (18.5%). Multidrug resistance (MDR) in bacteria was seen in 59.2% of isolates. BAL is a valuable diagnostic tool to find not only bacterial but mycobacterial and fungal infections in patients with lower respiratory tract infection (LRTI). A trend towards LRTI with Gram-negative infections is on the rise and they tend to be multidrug-resistant. Hence checking susceptibility patterns is crucial to start evidence-based treatment.

show abstract

Section: Discussionsupporting

confidence: 84%

Microbiota of Bronchoalveolar Lavage Samples from Patients of Lower Respiratory Tract Infection – A Changing Trend

Inamdar¹,

Anuradha²,

Inamdar³

et al. 2021

J. Pure Appl. Microbiol.

View full text Add to dashboard Cite

show abstract

“…In the present study we find the gram negative bacteria are highly sensitive to carbapenem drugs when compared to other studies, which has shown rise in carbapenem resistance in isolates from BAL. 8,9 A study conducted by Rahul et al found high prevalence of bacterial drug resistance in bacteria isolated from BAL. 7…”

Section: Resultsmentioning

confidence: 99%

Spectrum of pathogenic bacteria isolated from the bronchoalveolar lavage in a tertiary care centre at Hyderabad

Anisha¹,

Rajkumar²,

Reddy³

et al. 2020

IJMR

View full text Add to dashboard Cite

Pneumonia is the inflammation of the lung and several bacterial etiological agents are known to cause the infection. Studies have shown several gram negative bacteria including Pseudomonas spp, Klebsiella spp and gram positive bacteria such as Streptococcus spp are known to cause infection. In the present study we aim to evaluate the spectrum of bacterial isolates and their antibiotic sensitivity pattern isolated from BAL specimen. Materials and Methods: The retrospective study was carried out in a tertiary care center over a period of one year. The isolates were evaluated and identified with antibiotic sensitivity pattern. Results: The overall BAL specimen processed in a year were 90, in which culture were positive in 28 cases (31%). The organisms isolated were Pseudomonas aeruginosa, grown in 15 cases (52%), Klebsiella pneumoniae grown in 7 cases (28%), Escherichia.coli grown in 3 cases (10%) and Streptococcus pneumoniae in 3 cases (10%). Most of the organisms are sensitive to antibiotics. Conclusion:The present study has shown the most common isolate at our tertiary centre was Pseudomonas aeruginosa, followed by Klebsiella spp and in gram positive bacteria the common organism isolated was Streptococcus pneumoniae. Our results contribute to evaluate the common prevalent organisms causing pneumonia and also helps in improving the epidemiological knowledge.

show abstract

“…Carbapenem resistance in Enterobacteriaceae has been detected worldwide at alarming frequencies, including in Africa, Asia, Europe, North America and South America [19][20][21][22]. The prevalence and geographical distribution of various K. pneumoniae strains differ, but a particularly important strain involved in national and international epidemics is the sequence type (ST) 258 harbouring the K. pneumoniae carbapenemases (KPC) [19,[23][24][25].…”

Section: Epidemiology Of Multidrug-resistant Klebsiella Pneumoniaementioning

confidence: 99%

“…The prevalence and geographical distribution of various K. pneumoniae strains differ, but a particularly important strain involved in national and international epidemics is the sequence type (ST) 258 harbouring the K. pneumoniae carbapenemases (KPC) [19,[23][24][25]. The most important carbapenemases belong to the Ambler Class A [K. pneumoniae carbapenemase (KPC)], Class B [metallo-β-lactamases (MBL), such as New Delhi metallo-β-lactamases (NDM-1)] and Class D [Oxacillinases, particularly OXA-48-type carbapenemases] [6,20,25,51,52].…”

Section: Epidemiology Of Multidrug-resistant Klebsiella Pneumoniaementioning

confidence: 99%

“…The rise in carbapenemase-producers both locally and internationally poses a treatment dilemma as fewer efficacious antibiotics are available and all are threatened in light of the emergence of extensively drug-resistant (XDR) and pan-drugresistant (PDR) Gram-negative bacteria [16]. Carbapenem resistance in Enterobacteriaceae has been detected worldwide at alarming frequencies, including in Africa, Asia, Europe, North America and South America [19][20][21][22]. The prevalence and geographical distribution of various K. pneumoniae strains differ, but a particularly important strain involved in national and international epidemics is the sequence type (ST) 258 harbouring the K. pneumoniae carbapenemase (KPC) [19,[23][24][25].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Review - Understanding β-lactamase Producing Klebsiella pneumoniae

Jesus¹,

Ehlers²,

Santos³

et al. 2015

Antimicrobial Resistance - An Open Challenge

View full text Add to dashboard Cite

Klebsiella pneumoniae is a nosocomial pathogen commonly implicated in hospital outbreaks with a propensity for antimicrobial resistance towards mainstay β-lactam antibiotics and multiple other antibiotic classes. The successful proliferation, transmission and infection of the Gram-negative bacterium can be attributed to a myriad of factors including host factors, environmental factors, virulence factors and a large repertoire of antibiotic resistance mechanisms. The poor treatment outcomes and limited treatment options are consequences of the successful pathogenesis and spread of antibiotic resistance in the increasingly common β-lactamase producing K. pneumoniae bacterium. The review briefly explores the biology, successful pathogenesis and antibiotic resistance of K. pneumoniae as well as the detection and characterisation techniques of important strains.

show abstract

Carbapenem non-susceptible Klebsiella pneumoniae from Micronet network hospitals, Italy, 2009 to 2012

Cited by 33 publications

References 45 publications

Microbiota of Bronchoalveolar Lavage Samples from Patients of Lower Respiratory Tract Infection – A Changing Trend

Microbiota of Bronchoalveolar Lavage Samples from Patients of Lower Respiratory Tract Infection – A Changing Trend

Spectrum of pathogenic bacteria isolated from the bronchoalveolar lavage in a tertiary care centre at Hyderabad

Review - Understanding β-lactamase Producing Klebsiella pneumoniae

Contact Info

Product

Resources

About