Carbamyl analogs of phosphatidylcholines

Gupta, C. M.; Bali, Anu

doi:10.1016/0005-2760(81)90178-8

Cited by 45 publications

(17 citation statements)

References 23 publications

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“…Egg PC, MPC, egg [methyf-'4C]PC (35 &i/ pmol) and [methyl-'4C]MPC (15 ,&i/~mol) were prepared as in [12]. Al1 these phospholipids exhibited single spots on siIica gel G-60 thin-layer chromatography (TLC) plates.…”

Section: Methodsmentioning

confidence: 99%

“…Tissue uptake Lipid transfer [12,13]. Further studies with these lipids have revealed that complete replacement of egg PC in liposomes by MPC prevents serum-induced leakage of the entrapped solutes and also inhibits the Iipid transfer from liposomes to serum proteins [14].…”

Section: Plasma-induced Teakagementioning

confidence: 99%

“…This effect of the lipoprotein is reduced by increasing the CH content of the liposomes [6,7] or by an appropriate choice of the phospholipid component [g,lll. in an attempt to design liposomes that would be stable in blood, we have recently modified phosphatidylcholines by introducing one NH residue adjacent to the carbon atom of their C-2 ester group [ 121. This change rendered the resulting phospho~ipids selectively resistant to phospholipase A2 [12], without adversely affecting the physico-chemical properties of the liposomes Abbreviations: PC, phosphatidylchoiine; MPC, l-pal mitoyt-2-heptadec-lO-cis-enylcarbamyloxy-sn-glycero-3-phosphorylcholine; CH, cholesterol; 6-CF, Gcarboxyfluorescein; HDL, high density fraction of plasma lipoproteins * To whom correspondence should be addressed…”

Section: Introductionmentioning

confidence: 99%

“…The phospholipase AZ-resisting property of MPC will not result in its long-term toxicity, because this lipid would readily be degraded by other phospholipases [12]. The MPC/CH liposomes may, therefore, find some useful applications as drug carriers in therapy.…”

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confidence: 99%

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Stability of liposomes in circulation is markedly enhanced by structural modification of their phospholipid component

Bali¹,

Dhawan²,

Gupta³

1983

FEBS Letters

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Section: Methodsmentioning

confidence: 99%

Section: Plasma-induced Teakagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Stability of liposomes in circulation is markedly enhanced by structural modification of their phospholipid component

Bali¹,

Dhawan²,

Gupta³

1983

FEBS Letters

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“…Small unilamellar liposomes were prepared from 15 pmol egg PC, traces of egg [14C]PC (about lOpCi), 7.5 pmol CH and 6-CF (0.2 M) with or without I or II (7-8% by egg PC weight) in 0.8 ml TBS or SSTS by probe sonication [12], and fractionated by centrifugation in a Beckman L5-65B ultracentrifuge at 100 x lo3 g (SW-50.1 rotor) for 1 h at 5°C. Only the liposomes found in the top 3/4 of the supernatant were used.…”

Section: Liposomesmentioning

confidence: 99%

Specific interactions of liposomes with PMN leukocytes upon incorporating tuftsin in their bilayers

et al. 1984

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Incorporation of tuftsin derivatives, Thr‐Lys‐Pro‐Arg‐NH‐C18H37 or Thr‐Lys‐Pro‐Arg‐NH‐(CH2)2‐NH‐COC15H31, into an egg phosphatidylcholine/cholesterol liposome bilayer led to significantly enhanced binding of the liposomes to PMN leukocytes at 37°C but not at 0°C. Under identical conditions, no such enhanced binding of the liposomes was observed with erythrocytes and lymphocytes. These results demon‐strate that grafting of tuftsin on the liposome bilayer enables the liposome to recognize specifically the PMN leukocytes and to deliver its contents to these cells.

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Recent Developments in Nanomaterial‐Based Shear‐Sensitive Drug Delivery Systems

Wang

Pisapati

Zhang

et al. 2021

Adv Healthcare Materials

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Nanomaterial‐based drug delivery systems (DDSs) increase the efficacy of various therapeutics, and shear stress has been shown to be a robust modulator of payload release. In the past few decades, a deeper understanding has been gained of the effects of flow in the body and its alteration in pathological microenvironments. More recently, shear‐responsive nanomaterial DDSs have been developed. Studies on this subject mainly from the last decade are reviewed here, focusing on innovations of the material design and mechanisms of the shear response. The two most popular shear‐controlled drug carriers distinguished by different release mechanisms, that is, shear‐deformable nanoparticles (NPs) and shear‐dissociated NP aggregates (NPAs), are surveyed. The influence of material structures on their properties such as drug loading, circulation time, and shear sensitivity are discussed. The drug development stages, therapeutic effects, limitations, and potential of these DDSs are further inspected. The reviewed research emphasizes the advantages and significance of nanomaterial‐based shear‐sensitive DDSs in the field of targeted drug delivery. It is also believed that efforts to rationally design nanomaterial DDSs responsive to shear may prompt a new class of diagnostics and therapeutics for signaling and rectifying pathological flows in the body.

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Carbamyl analogs of phosphatidylcholines

Cited by 45 publications

References 23 publications

Stability of liposomes in circulation is markedly enhanced by structural modification of their phospholipid component

Stability of liposomes in circulation is markedly enhanced by structural modification of their phospholipid component

Specific interactions of liposomes with PMN leukocytes upon incorporating tuftsin in their bilayers

Recent Developments in Nanomaterial‐Based Shear‐Sensitive Drug Delivery Systems

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