Carbamates Derived From Vanillin and Their Molluscicidal, Larvicidal and Antimicrobial Activities

Latif, N.; Mishriky, N.; Girgis, N. S.; Arnos, S.

doi:10.1016/b978-0-08-023930-9.50093-9

Cited by 6 publications

(8 citation statements)

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“…5-Amino-1-phenylpyrazole (1) 27 , chalcone analogues 2a-f 28-32 , arylidenecyanoacetate ester 4a,b 33 , substituted benzylidenemalononitrile 6 33 and pyridone derivatives 8a-c [34][35][36] were prepared according to the literature. (7): A solution of 5-amino-1-phenylpyrazole (1) (0.0015 mol), the appropriate arylidenecyanoacetate ester 4a,b or substituted benzylidenemalononitrile 6 (0.0015 mol) and triethylamine (1 mL) in absolute ethanol (10 mL) was heated under reflux for 4 h. The reaction mixture was cooled and acidified to litmus paper with drops of conc.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Pyrazolo[3,4-b]Pyridine and Pyrido[2′,3′:3,4]Pyrazolo [1,5-a]Pyrimidine Derivatives

El-Enany

Elmeligie

Abdou

et al. 2010

Journal of Chemical Research

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The synthesis of two series of 1-phenyl and 1H -pyrazolo [3,4-b]pyridine is described. Thus, reacting 5-amino-1phenylpyrazole with chalcone analogues gave 4,6-diarylpyrazolo[3,4-b]pyridine derivatives. While, reacting the same starting material with benzylidene derivatives of ethyl cyanoacetate and malononitrile resulted in 4-oxo and 4aminopyrazolo[3,4-b]pyridine derivatives, respectively. The synthesis of 3-amino-4,6-diarylpyrazolo[3,4-b]pyridines starting from pyridine was also described. Thus, chlorination of 4,6-diarylpyridone derivatives and their subsequent cyclisation with hydrazine hydrate afforded 3-amino-4,6-diarylpyrazolo [3,4-b]pyridines. Reaction of the latter compounds with acetylacetone, ethyl ethoxymethylenecyanoacetate and chalcone analogue gave the tricyclic pyrido[2p,3p: 3,4]pyrazolo[1,5-a]pyrimidines. The structures of the products were confirmed by spectral data.

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Section: Methodsmentioning

confidence: 99%

Synthesis of Pyrazolo[3,4-b]Pyridine and Pyrido[2′,3′:3,4]Pyrazolo [1,5-a]Pyrimidine Derivatives

El-Enany

Elmeligie

Abdou

et al. 2010

Journal of Chemical Research

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“…The nitroalkene compounds are commonly synthesized by the dehydration of β-nitroalcohols that are in situ prepared by Henry reaction of various aldehydes with a nitroalkane in a basic condition, in which the dehydration of β-nitroalcohols are achieved by a transformation of the hydroxyl group into a good leaving group or simply by heating in an acidic condition 1,2 . Particularly, the aromatic nitroalkene compounds have been proved to be a significant class of the nitroalkenes, which possess diverse biological activities such as mollusicicidal activities 3,4 , insecticidal activities 4 , antimicrobial activities 5,6 , anticancer activities 7 and anti HVI-1 activities 8 etc. Detailed study on the synthesis and structures of such compounds seems very important to better understand the relationship between molecular structures and biological activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Crystal Structure of trans-2-(2,4,6-Trimethylphenyl)-1-Nitroethylene

Zhao¹,

Zhang²,

Zhao³

2013

Asian J. Chem.

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“…In recent years, there have been many studies investigating the biological effects and functions of these compounds, with nitrostyrenes having been shown to have antimicrobial 39,41 and insecticidal 42 properties. Some have even been shown to affect the down regulation of interleukins, suggesting an immunological role 43 .…”

Section: Insert Figmentioning

confidence: 99%

Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents

McNamara¹,

Cloonan²,

Knox³

et al. 2011

Bioorganic & Medicinal Chemistry

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Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents, Bioorganic & Medicinal Chemistry (2010), doi: 10.1016/j.bmc.2010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. derived cell lines, whilst having no effect on 'normal' peripheral blood mononuclear cells. Such effects appear to be independent of the serotonin transporter, a high affinity target for amphetamines and independent of protein tyrosine phosphatases and tubulin dynamics both of which have been previously associated with nitrostyrene-induced cell death. We demonstrate that a number of these compounds induce caspase activation, PARP cleavage, chromatin condensation and membrane blebbing in a Burkitt's lymphoma-derived cell line, consistent with these compounds inducing apoptosis in vitro. Although no specific target has yet been identified for the action of these compounds, the cell death elicited is potent, selective and worthy of further investigation.

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Carbamates Derived From Vanillin and Their Molluscicidal, Larvicidal and Antimicrobial Activities

Cited by 6 publications

References 0 publications

Synthesis of Pyrazolo[3,4-b]Pyridine and Pyrido[2′,3′:3,4]Pyrazolo [1,5-a]Pyrimidine Derivatives

Synthesis of Pyrazolo[3,4-b]Pyridine and Pyrido[2′,3′:3,4]Pyrazolo [1,5-a]Pyrimidine Derivatives

Synthesis and Crystal Structure of trans-2-(2,4,6-Trimethylphenyl)-1-Nitroethylene

Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents

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