Abstract:RESUMEN Para evaluar de manera fidedigna el riesgo de ruptura de la aorta – junto a los índices de peligrosidad de enfermedades cardiovasculares u otras condiciones extremas y los efectos de posibles tratamientos – se requiere conocer los mecanismos de daño que conducen a ésta. En este trabajo, se caracteriza el daño mecánico del tejido aórtico en condición de hipoxia, analizando numéricamente su respuesta al ser sujeto a un estado de presurización similar al inducido por un ensayo de acopado hidráulico. El co… Show more
“…Their main results did not reveal significant evidence of changes on the ex-vivo mechanical response of arterial tissue. A similar trend was reported by Bezmalinovic et al (2021) , who addressed the hyperelastic and damage properties of thoracic aortas in the same animal model and treatment as Rivera et al (2020) . Besides, Navarrete et al (2020) determined the effect of Atrial Natriuretic Peptide (ANP) and Cinaciguat on arterial residual strains, considering the same environmental conditions and animal model than Rivera et al (2020) .…”
Section: Introductionsupporting
confidence: 71%
“…Therein, no significant differences were found on the mechanical parameters from uniaxial-tensile tests, neither on slopes at low and high strain, nor on the transition stress and stretch. Likewise, Bezmalinovic et al (2021) evaluated thoracic aortas of lambs subjected to chronic HAHH and treated with melatonin, finding no significant differences on the uniaxial stress. After analyzing the biomechanical parameters presented in Tables 2 , 3 , it can be seen that there is a tendency for a greater degree of material stiffness in both arterial zones when treatment is applied.…”
Section: Discussionmentioning
confidence: 99%
“…This study was performed on aorta, carotid and femoral arteries, finding significant changes in the residual strain measurements on treated subjects. More recently, Laubrie et al (2023) studied the effect of Cinaciguat on the hyperelastic, damage and dissipation behavior of thoracic aortas on the same animal model as Rivera et al (2020) , Navarrete et al (2020) and Bezmalinovic et al (2021) . The initial progress in this area reflects the need to better understand the effects of new treatments on the arterial-wall response, in order to have a more global overview related to the application of these therapies.…”
Introduction: Gestation under chronic hypoxia causes pulmonary hypertension, cardiovascular remodeling, and increased aortic stiffness in the offspring. To mitigate the neonatal cardiovascular risk, pharmacological treatments (such as hemin and sildenafil) have been proposed to improve pulmonary vasodilation. However, little is known about the effects of these treatments on the aorta. Therefore, we studied the effect of hemin and sildenafil treatments in the aorta of lambs gestated and raised at highlands, thereby subjected to chronic hypoxia.Methods: Several biomechanical tests were conducted in the descending thoracic aorta (DTA) and the distal abdominal aorta (DAA), assessing 3 groups of study of hypoxic animals: non-treated (Control) and treated either with hemin or sildenafil. Based on them, the stiffness level has been quantified in both zones, along with the physiological strain in the unloaded aortic duct. Furthermore, a morphological study by histology was conducted in the DTA.Results: Biomechanical results indicate that treatments trigger an increment of axial pre-stress and circumferential residual stress levels in DTA and DAA of lambs exposed to high-altitude chronic hypoxia, which reveals a vasodilatation improvement along with an anti-hypertensive response under this characteristic environmental condition. In addition, histological findings do not reveal significant differences in either structure or microstructural content.Discussion: The biomechanics approach emerges as a valuable study perspective, providing insights to explain the physiological mechanisms of vascular function. According to established results, alterations in the function of the aortic wall may not necessarily be explained by morphostructural changes, but rather by the characteristic mechanical state of the microstructural components that are part of the studied tissue. In this sense, the reported biomechanical changes are beneficial in mitigating the adverse effects of hypobaric hypoxia exposure during gestation and early postnatal life.
“…Their main results did not reveal significant evidence of changes on the ex-vivo mechanical response of arterial tissue. A similar trend was reported by Bezmalinovic et al (2021) , who addressed the hyperelastic and damage properties of thoracic aortas in the same animal model and treatment as Rivera et al (2020) . Besides, Navarrete et al (2020) determined the effect of Atrial Natriuretic Peptide (ANP) and Cinaciguat on arterial residual strains, considering the same environmental conditions and animal model than Rivera et al (2020) .…”
Section: Introductionsupporting
confidence: 71%
“…Therein, no significant differences were found on the mechanical parameters from uniaxial-tensile tests, neither on slopes at low and high strain, nor on the transition stress and stretch. Likewise, Bezmalinovic et al (2021) evaluated thoracic aortas of lambs subjected to chronic HAHH and treated with melatonin, finding no significant differences on the uniaxial stress. After analyzing the biomechanical parameters presented in Tables 2 , 3 , it can be seen that there is a tendency for a greater degree of material stiffness in both arterial zones when treatment is applied.…”
Section: Discussionmentioning
confidence: 99%
“…This study was performed on aorta, carotid and femoral arteries, finding significant changes in the residual strain measurements on treated subjects. More recently, Laubrie et al (2023) studied the effect of Cinaciguat on the hyperelastic, damage and dissipation behavior of thoracic aortas on the same animal model as Rivera et al (2020) , Navarrete et al (2020) and Bezmalinovic et al (2021) . The initial progress in this area reflects the need to better understand the effects of new treatments on the arterial-wall response, in order to have a more global overview related to the application of these therapies.…”
Introduction: Gestation under chronic hypoxia causes pulmonary hypertension, cardiovascular remodeling, and increased aortic stiffness in the offspring. To mitigate the neonatal cardiovascular risk, pharmacological treatments (such as hemin and sildenafil) have been proposed to improve pulmonary vasodilation. However, little is known about the effects of these treatments on the aorta. Therefore, we studied the effect of hemin and sildenafil treatments in the aorta of lambs gestated and raised at highlands, thereby subjected to chronic hypoxia.Methods: Several biomechanical tests were conducted in the descending thoracic aorta (DTA) and the distal abdominal aorta (DAA), assessing 3 groups of study of hypoxic animals: non-treated (Control) and treated either with hemin or sildenafil. Based on them, the stiffness level has been quantified in both zones, along with the physiological strain in the unloaded aortic duct. Furthermore, a morphological study by histology was conducted in the DTA.Results: Biomechanical results indicate that treatments trigger an increment of axial pre-stress and circumferential residual stress levels in DTA and DAA of lambs exposed to high-altitude chronic hypoxia, which reveals a vasodilatation improvement along with an anti-hypertensive response under this characteristic environmental condition. In addition, histological findings do not reveal significant differences in either structure or microstructural content.Discussion: The biomechanics approach emerges as a valuable study perspective, providing insights to explain the physiological mechanisms of vascular function. According to established results, alterations in the function of the aortic wall may not necessarily be explained by morphostructural changes, but rather by the characteristic mechanical state of the microstructural components that are part of the studied tissue. In this sense, the reported biomechanical changes are beneficial in mitigating the adverse effects of hypobaric hypoxia exposure during gestation and early postnatal life.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.