Biomechanical effects of hemin and sildenafil treatments on the aortic wall of chronic-hypoxic lambs
Álvaro Navarrete,
Matías Inostroza,
Andrés Utrera
et al.
Abstract:Introduction: Gestation under chronic hypoxia causes pulmonary hypertension, cardiovascular remodeling, and increased aortic stiffness in the offspring. To mitigate the neonatal cardiovascular risk, pharmacological treatments (such as hemin and sildenafil) have been proposed to improve pulmonary vasodilation. However, little is known about the effects of these treatments on the aorta. Therefore, we studied the effect of hemin and sildenafil treatments in the aorta of lambs gestated and raised at highlands, the… Show more
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