Caracterização química e citotoxicidade do óleo essencial do cravo-da-índia (Syzygium aromaticum)

Gomes, Paulo Roberto Barros; Filho, Victor Elias Mouchrek; Rabêlo, Waléria Ferreira; Nascimento, Alexandre Albuquerque do; Louzeiro, Hilton Costa; Lyra, Wellington da Silva; Fontenele, Maria Alves

doi:10.15446/rcciquifa.v47n1.70657

Cited by 16 publications

(9 citation statements)

References 13 publications

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“…Otherwise, slow distillation overloads the product with undesirable flavors 54 . Generally, the best yields are obtained from the time of 3 h [26][27][28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

Larvicidal activity, molluscicide and toxicity of the essential oil of Citrus limon peels against, respectively, Aedes aegypti, Biomphalaria glabrata and Artemia salina

Gomes

Oliveira

Sousa³

et al. 2019

Eclet. Quim. J.

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In this present work, we tested the larvicidal activity, molluscicide and toxicity of the oil extracted from Citrus limon peels, respectively against third stage larvae of Aedes aegypti, snail Biomphalaria glabrata, and Artemia salina. For this, we extract the essential oil by hydrodistillation. Then, we identified and quantified the components by gas chromatography coupled to mass spectrometry (GC-MS). We tested the larvicidal and molluscicidal activity, respectively, using the method adopted by the Brazilian Ministry of Health and the World Health Organization. We calculated the lethal concentration (LC50) from the Probit method for the three biological activities with 95 %. The results of the chromatographic analysis showed that the oil has 58.81% of Limonene (major constituent) and 0.11% α-Mulene (minority component). The essential oil presented lethal concentration (LC50) for larvicidal activity, molluscicide and toxicity, respectively at 15.48, 13.05 and 743.35 mg∙L-1. Therefore, the essential oil is active against larvae of A. aegypti and snail B. glabrata and non-toxic against larvae of A. salina.

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“…Otherwise, slow distillation overloads the product with undesirable flavors 54 . Generally, the best yields are obtained from the time of 3 h [26][27][28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

Larvicidal activity, molluscicide and toxicity of the essential oil of Citrus limon peels against, respectively, Aedes aegypti, Biomphalaria glabrata and Artemia salina

Gomes

Oliveira

Sousa³

et al. 2019

Eclet. Quim. J.

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“…A quantidade de β-cariofileno e eugenol atendeu aos requisitos de óleo de cravo aceitáveis pela Farmacopéia Européia, 5,0 a 14,0% e 75,0 a 88,0%, respectivamente (Teles et al, 2021). Outros autores encontraram resultados semelhantes (Cortés-Rojas; Souza; Oliveira, 2014;Baker;Grant, 2017;Kheawfu et al, 2017;Nikoui et al, 2017;Gomes et al, 2018;Zanusso Junior et al, 2018;Hadidi et al, 2020;Scandiffio et al, 2020;Kacaniová et al, 2021;Teles et al, 2021;Hekmatpanah et al, 2022). Atividades farmacológicas importantes são atribuídas à essas substâncias: antimicrobiana (Kacaniová et al, 2021;Hekmatpanah et al, 2022), anti-inflamatória (Nikoui et al, 2017;Scandiffio et al, 2020) anestésica (Kheawfu et al, 2017.…”

Section: Atividade Antioxidante: Dpphunclassified

Development of Syzygium aromaticum (L.) essential oil encapsulates by ionic gelification and evaluation of antioxidant activity

Mergulhão,

Bulhões,

Silva

et al. 2024

CLIUM

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The objective of this work was to develop a product capable of protecting Syzygium aromaticum (clove) essential oil against high volatility. Clove oil (CEO) was encapsulated in alginate by ionic gelation with subsequent freeze-drying. Characterization was carried out by GC/MS, TGA/DSC and antioxidant (DPPH), and total phenol (Folin-Ciocalteau) analysis. Eugenol was the majority (81.5%) and the encapsulation efficiency varied between 14.0%+0.96 (F1: 1.0% alginate) and 9.8%+0.35 (F2: 2.0% alginate) in wet encapsulates, and 23.5%+0.14 (LF1: 1.0% alginate) and 16.9%+0.16 (LF2: 2.0% alginate) in freeze-dried encapsulates. The total phenol content reached 714.8+0.97 EAG g-1 in LF1, with strong inhibition of the DPPH radical (71.4%). Freeze-drying provided a higher percentage of active ingredients per gram of encapsulated and it was possible to identify high thermal stability in LF1 (mass loss: 81.8%; 258.9 °C) compared to wet encapsulates (mass loss: 86.5%; 65.8°C). The use of the lowest concentration of alginate seems to have been favorable. In this way, the accessible technology used allows preserving the content and properties of the CEO, offering a basis for new encapsulated research.

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“…Total oil yield was expressed as percentage (g 100 g -1 of fresh plant material) and color, and appearance were evaluated by the organoleptic analysis method (Gomes et al, 2018). The solubility of essential oil was determined in a solution of 70% (v/v) ethanol as described by Alarcón et al (2019).…”

Section: Physicochemical Analysismentioning

confidence: 99%

Chemical profile and antioxidant, antibacterial, and cytotoxic activities on Artemia salina from the essential oil of leaves and xylopodium of Cochlospermum regium

Magalhães¹,

Filho

Ventura

et al. 2021

Sci. Elec. Arch.

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Cochlospermum regium is a shrub plant species from the Cerrado domain used in traditional medicine. This study aimed to evaluate the chemical profile and antioxidant, antibacterial and cytotoxic activities on Artemia salina from the essential oil of fresh leaves and xylopodium. Fresch leaves and xylopodium of C. regium were collected in an area of Cerrado domain in Goiás State, Brazil, 2021. The essential oil was obtained by hydrodistillation, the yield was quantified and the chemical profile determined by gas chromatography with mass spectrometry (GC-MS). Physicochemical analyzes were carried out for organoleptic analysis (color and appearance), solubility, relative density (g mL-1), refractive index, optical rotation (αD), antioxidant activity in DPPH radical reduction (IC50 µL mL-1), antibacterial activity on Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Salmonella serovar Enteritidis and Salmonella serovar Thyphymurium by the disc method (mm), and cytotoxicity bioassay on Artemia salina (LC50 µg mL-1). The major compounds for the essential oil of fresh leaves were viridiflorol 10.21%, Copaen-4-α-ol <β>, longiborneol 9.07 and β-bisabolene 11.48%, and for the essential oil of xylopodium β-selinene 26.17%, aromadendrene 8.66 % and thujopsene 8.09%. The yield was 0.58 and 0.33%, color slightly yellow and yellow for fresh leaves and xylopodium, respectively. Positive solubility, refractive index of 1.3468 and 1.3347, optical rotation +48.8 and +21.5, relative density 0.932 and 0.936 g mL-1, antioxidant activity IC50 = 47.65 and 111.16 µL mL-1 for fresh leaves essential oil and xylopodium, respectively. The essential oil from fresh leaves showed high antibacterial potential for all strains, as well as for cytotoxic activity on A. salina with LC50 = 90.17 and 625.08 µg mL-1, respectively.

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Caracterização química e citotoxicidade do óleo essencial do cravo-da-índia (Syzygium aromaticum)

Cited by 16 publications

References 13 publications

Larvicidal activity, molluscicide and toxicity of the essential oil of Citrus limon peels against, respectively, Aedes aegypti, Biomphalaria glabrata and Artemia salina

Larvicidal activity, molluscicide and toxicity of the essential oil of Citrus limon peels against, respectively, Aedes aegypti, Biomphalaria glabrata and Artemia salina

Development of Syzygium aromaticum (L.) essential oil encapsulates by ionic gelification and evaluation of antioxidant activity

Chemical profile and antioxidant, antibacterial, and cytotoxic activities on Artemia salina from the essential oil of leaves and xylopodium of Cochlospermum regium

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