Objective: to evaluate the implementation of schistosomiasis mansoni control actions under the Program to Combat Neglected Diseases in three municipalities in Pernambuco state, Brazil. Methods: implementation analysis was done in 2014, considering the following components-management, epidemiological surveillance, patient care, laboratorial support and health education-; direct observation and interviews were carried out with managers and technical personnel at the state, regional, and municipal levels. Results: partial implementation was found in municipalities A and B (69.7%; 62.2%), while there was full implementation in municipality C (79.5%); contextual weaknesses were found in communication between management levels, insufficient technical-management autonomy of decentralized levels, and professional staff job instability; potentialities identified were-continuing education, political articulation, knowledge about the program, and performance evaluation. Conclusion: contextual categories related to development and implementation stood out for their positive influence on the degree of implementation in the municipalities; we recommend intervention in the weaknesses found, in order to ensure program sustainability and institutionalization.