Caracterização de derivado arilbutanoídico em folhas e raízes de Ottonia anisum Sprengel

Abstract

RESUMO:A família Piperaceae é formada por 5 gêneros, Piper, Peperomia, Pothomorphe, Ottonia e Sarcorhachis, com cerca de 2000 espécies de ampla distribuição nas regiões tropicais e subtropicais do mundo. Das 23 espécies descritas para o gênero Ottonia, a maioria é nativa do Brasil. Essas plantas são popularmente utilizadas no país como diuréticas, salivantes e anestésicas. O estudo químico dos extratos apolares de folhas e de raízes de Ottonia anisum Sprengel levou ao isolamento de um componente majoritário identifi cado como o derivado arilbutanoídico: 1-butil-3,4-metilenodioxibeneno.Unitermos: Piperaceae, Ottonia anisum, 1-butil-3,4-metilenodioxibeneno.ABSTRACT: "Characterization of an arylbutanoic derivative from leaves and roots of Ottonia anisum Sprengel". The family Piperaceae encompasses 5 genera, Piper, Peperomia, Pothomorphe, Ottonia and Sarcorhachis, and approximately 2,000 species widely distributed in the tropical and subtropical regions of the world. Most of the Ottonia species are native to Brazil and they are used in folk medicine as diuretic, salivating, and anaesthetic. Chemical studies of non-polar fractions from leaves and roots of Ottonia anisum Sprengel lead to the isolation of an arylbutanoic metabolite, the 1-butyl-3,4-methylenedioxybezene.

Larvicidal activities and chemical composition of essential oils from Piper klotzschianum (Kunth) C. DC. (Piperaceae)

“…By these data, it was possible to confirm that the major component present in this oil was the phenylpropanoid 1‐butyl‐3,4‐methylenedioxybenzene. These spectroscopic data are in agreement with data in the literature with respect to this substance . This compound was previously found in species of P. vahlii and P. anisum …”

Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae)

“…O. anisum is used in the traditional medicine and in religious rituals (Parente and Rosa 2001, Azevedo and Silva, 2006, Leitão et al 2014. Previous phytochemical investigation of O. anisum resulted in the isolation and identification of amides piperovatine and (2E, 4E)-N-isobutyl-9-piperonyl-nona-2,4-dienoic from the leaves, 1-butyl-3,4-methylenedioxybenzene from the leaves and roots as well as aristolactams from the roots (Marques et al 2008, Moreira et al 1997, Giesbrecht et al 1981.…”

Aristolactams from roots of Ottonia Anisum (Piperaceae)

“…Previous phytochemical investigations of Piperaceae species from Brazilian Atlantic Forest performed by our research group led to the isolation of several compounds, such as kaplanin, lhotzchromene and blandachromenes I and II [3a-c]. In order to continue with the phytochemical studies of native Piperaceae species from Southeast Brazil, Ottonia anisum have been successfully studied [4]. The O. anisum root extracts were chemically investigated to afford six aristolactams.…”